Author details

Full Name

Floyd E Romesberg

Affiliation

ORCID

Career Start Year

1995

Papers

172

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36633274	Discovery, implications and initial use of semi-synthetic organisms with an expanded genetic alphabet/code.		2023
34710400	Creation, Optimization, and Use of Semi-Synthetic Organisms that Store and Retrieve Increased Genetic Information.	Journal of Molecular Biology	2022
33756076	Genetic Code Expansion: Inception, Development, Commercialization.	Journal of the American Chemical Society	2021
34140682	Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.	Nat Chem Biol	2021
34096294	Efforts toward Further Integration of an Unnatural Base Pair into the Biology of a Semisynthetic Organism.	Journal of the American Chemical Society	2021
32614583	Initial Analysis of the Arylomycin D Antibiotics.	Journal of Natural Products	2020
31961667	Selection of Aptamers with Large Hydrophobic 2'-Substituents.	Journal of the American Chemical Society	2020
32251411	New codons for efficient production of unnatural proteins in a semisynthetic organism.	Nature Chemical Biology	2020
31985216	Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair.	Journal of the American Chemical Society	2020
33118814	Transcription and Reverse Transcription of an Expanded Genetic Alphabet In Vitro and in a Semisynthetic Organism.	Journal of the American Chemical Society	2020
31241334	Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism.	Journal of the American Chemical Society	2019
31841336	Progress toward Eukaryotic Semisynthetic Organisms: Translation of Unnatural Codons.	Journal of the American Chemical Society	2019
30420476	Inhibition of Protein Secretion in <i>Escherichia coli</i> and Sub-MIC Effects of Arylomycin Antibiotics.	Antimicrob Agents Chemother	2019
31016704	Site-Specific Labeling of DNA via PCR with an Expanded Genetic Alphabet.	Methods in Molecular Biology	2019
31117391	Eight-Letter DNA.	Biochemistry	2019
31243995	Structure and Dynamics of Stacking Interactions in an Antibody Binding Site.	Biochemistry	2019
29198111	Expansion of the Genetic Alphabet: A Chemist's Approach to Synthetic Biology.	Accounts of Chemical Research	2018
30270151	Editorial overview: Expanding the genetic alphabet and code.	Current Opinion in Chemical Biology	2018
30205312	Expansion of the genetic code via expansion of the genetic alphabet.	Current Opinion in Chemical Biology	2018
30418780	Progress Toward a Semi-Synthetic Organism with an Unrestricted Expanded Genetic Alphabet.	Journal of the American Chemical Society	2018
29670704	Optimization of a Î²-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.	ACS Medicinal Chemistry Letters	2018
29624384	Semisynthetic Organisms with Expanded Genetic Codes.	Biochemistry	2018
29309130	Reprograming the Replisome of a Semisynthetic Organism for the Expansion of the Genetic Alphabet.	Journal of the American Chemical Society	2018
29260873	Topological Evidence of Previously Overlooked N-HÂ·Â·Â·N H-Bonds and Their Contribution to Protein Structure and Stability.	Journal of Physical Chemistry A	2018
29381350	Scalable Access to Arylomycins via C-H Functionalization Logic.	Journal of the American Chemical Society	2018
29338214	A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria.	Journal of the American Chemical Society	2018
28115716	A semisynthetic organism engineered for the stable expansion of the genetic alphabet.	Proceedings of the National Academy of Sciences of the United States of America	2017
28914996	Enzymatic Synthesis, Amplification, and Application of DNA with a Functionalized Backbone.	Angewandte Chemie - International Edition	2017
28768812	Reply to Hettinger: Hydrophobic unnatural base pairs and the expansion of the genetic alphabet.	Proceedings of the National Academy of Sciences of the United States of America	2017
28547993	Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid.	Biochemistry	2017
28715205	Polymerase Chain Transcription: Exponential Synthesis of RNA and Modified RNA.	Journal of the American Chemical Society	2017
28796508	In Vivo Structure-Activity Relationships and Optimization of an Unnatural Base Pair for Replication in a Semi-Synthetic Organism.	Journal of the American Chemical Society	2017
28930440	A Method for the Exponential Synthesis of RNA: Introducing the Polymerase Chain Transcription (PCT) Reaction.	Biochemistry	2017
28654252	Synthetic Biology Parts for the Storage of Increased Genetic Information in Cells.	ACS Synthetic Biology	2017
29568464	Evolved polymerases facilitate selection of fully 2'-OMe-modified aptamers.	Chemical Science	2017
29233892	Stable Signal Peptides and the Response to Secretion Stress in .	mBio	2017
29189780	A semi-synthetic organism that stores and retrieves increased genetic information.	Nature	2017
28218835	Selection of 2'-Fluoro-Modified Aptamers with Optimized Properties.	Journal of the American Chemical Society	2017
28170246	Chemical Stabilization of Unnatural Nucleotide Triphosphates for the in Vivo Expansion of the Genetic Alphabet.	Journal of the American Chemical Society	2017
28106985	Transparent Window Vibrational Probes for the Characterization of Proteins With High Structural and Temporal Resolution.	Chemical Reviews	2017
27769673	Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence.	Bioorganic and Medicinal Chemistry	2016
27219699	Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA.	Nature Chemistry	2016
26942998	FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs.	ACS Chemical Biology	2016
27932231	Discovery of novel antibacterials.	Bioorganic and Medicinal Chemistry	2016
27565457	The expanding world of DNA and RNA.	Current Opinion in Chemical Biology	2016
26286693	An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus.	mBio	2015
25756188	Adaptive mutations alter antibody structure and dynamics during affinity maturation.	Biochemistry	2015
25753642	A putative cro-like repressor contributes to arylomycin resistance in Staphylococcus aureus.	Antimicrobial Agents and Chemotherapy	2015
25896690	Origins of Yersinia pestis sensitivity to the arylomycin antibiotics and the inhibition of type I signal peptidase.	Antimicrobial Agents and Chemotherapy	2015
26276537	The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential.	Bioorganic and Medicinal Chemistry Letters	2015