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Author Details

Kasper Lage
2006
70
39
PMIDPaper TitleJournal TitlePublished Year
37443254Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.Nat Genet2023
36950384Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.Cell Genom2023
35110736Autism genes converge on asynchronous development of shared neuron classes.Nature2022
36527106Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells.2022
34849650Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.Cardiovasc Res2022
34568833<i>ZBTB33</i> is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing.Blood Cancer Discov2021
34294919Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.Nat Neurosci2021
33972534Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data.Nat Commun2021
33790022Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.Sci Transl Med2021
33568741Systematic auditing is essential to debiasing machine learning in biology.Commun Biol2021
33351783Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.JCI Insight2021
32657361Prediction of cancer driver genes through network-based moment propagation of mutation scores.2020
32325033BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.Cell Syst2020
32853540BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.Cell Syst2020
32620954TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.Hum Mol Genet2020
33106425Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.Proc Natl Acad Sci U S A2020
30914061Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.Genome Medicine2019
31492854Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology.Nat Commun2019
31232694Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility.eLife2019
29200198NetSig: network-based discovery from cancer genomes.Nat Methods2018
29915188GeNets: a unified web platform for network-based genomic analyses.Nat Methods2018
29955178Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer.Nat Genet2018
27892958A scored human protein-protein interaction network to catalyze genomic interpretation.Nat Methods2017
29262854Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.Genome Med2017
27684187Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.Cell Syst2016
27147599Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.Cancer Discov2016
27253518CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.PLoS ONE2016
2765946652 Genetic Loci Influencing Myocardial Mass.J Am Coll Cardiol2016
24702427Prevalence and penetrance of ZFPM2 mutations and deletions causing congenital diaphragmatic hernia.Clin Genet2015
25574029MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.Hum Mol Genet2015
26392535Comprehensive assessment of cancer missense mutation clustering in protein structures.Proc Natl Acad Sci U S A2015
26509271Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease.PLoS Genet2015
25107291Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics.Proc Natl Acad Sci U S A2014
24952909Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.Nat Methods2014
24952745Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Nat Genet2014
24667040An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.Genome Biol2014
24892209Protein-protein interactions and genetic diseases: The interactome.2014
23703204MetaRanker 2.0: a web server for prioritization of genetic variation data.Nucleic Acids Res2013
23937086Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: a proteomic study of the pathways involved.Journal of Proteome Research2013
23793025Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nat Genet2013
24092746Integrative annotation of variants from 1092 humans: application to cancer genomics.Science2013
23643382Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.Am J Hum Genet2013
23656588Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.N Engl J Med2013
22103328Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.J Proteome Res2012
22673903Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.Nature Communications2012
22904188Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.Proc Natl Acad Sci U S A2012
22902405Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.Cell Rep2012
22521361Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.Cell2012
22315423Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes.Proc Natl Acad Sci U S A2012
23165946Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks.Am J Med Genet A2012
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Weill Institute for Cell and Molecular Biology, Cornell University
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