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Author Details

Michael W Mather
Center for Molecular Parasitology, Drexel University College of Medicine
1982
63
31
PMIDPaper TitleJournal TitlePublished Year
37406344Unique Properties of Apicomplexan Mitochondria.Annu Rev Microbiol2023
35984838Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum.PLoS One2022
33361312Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum.Antimicrob Agents Chemother2021
32191848Divergent Mitochondrial Ribosomes in Unicellular Parasitic Protozoans.Trends Parasitol2020
32273345Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions.J Biol Chem2020
30964863Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.PLoS One2019
30709568para-Aminobenzoate Synthesis versus Salvage in Malaria Parasites.Trends Parasitol2019
29626096The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in <i>Plasmodium falciparum</i>.J Biol Chem2018
30098918Novel Defense Peptides from Platelets Kill Malaria Parasites.Trends Parasitol2018
28927276Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.ACS Infect Dis2017
28708996Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.Cell2017
27015086Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p.PLoS One2016
27799215Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity.Antimicrob Agents Chemother2016
25918204Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.Am J Trop Med Hyg2015
26124159ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.Antimicrob Agents Chemother2015
25843709Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.Cell Rep2015
24720377Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.J Med Chem2014
25352601The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.J Biol Chem2014
23515079Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med2013
23615611Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.Nature2013
22640832Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.Mol Biochem Parasitol2012
21251930Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.Mol Biochem Parasitol2011
21984828ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.J Biol Chem2011
22004680Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.Genome Biol2011
21685321Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.Eukaryot Cell2011
20644710Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila.PLoS Biol2010
20686576Branched tricarboxylic acid metabolism in Plasmodium falciparum.Nature2010
20674615Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.Mol Biochem Parasitol2010
19575561Mitochondrial evolution and functions in malaria parasites.Annu Rev Microbiol2009
18023619The validity of mitochondrial dehydrogenases as antimalarial drug targets.Trends Parasitol2008
18814021Mitochondria in malaria and related parasites: ancient, diverse and streamlined.J Bioenerg Biomembr2008
17330044Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.Nature2007
17266530Mitochondrial drug targets in apicomplexan parasites.Curr Drug Targets2007
15917236Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.J Biol Chem2005
16265893A post-genomic view of the mitochondrion in malaria parasites.Curr Top Microbiol Immunol2005
11850032The inhibition of calcium signaling in T lymphocytes from old mice results from enhanced activation of the mitochondrial permeability transition pore.Mech Ageing Dev2002
12368864Genome sequence of the human malaria parasite Plasmodium falciparum.Nature2002
11115647Polycations induce the release of soluble intermembrane mitochondrial proteins.Biochim Biophys Acta2001
30147546Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria.ScientificWorldJournal2001
11498396Atovaquone resistance in malaria parasites.Drug Resist Updat2000
10873652Aging enhances the activation of the permeability transition pore in mitochondria.Biochem Biophys Res Commun2000
9774409Flexibility of the neck region of the rieske iron-sulfur protein is functionally important in the cytochrome bc1 complex.J Biol Chem1998
9738940Intrinsic uncoupling of cytochrome c oxidase may cause the maternally inherited mitochondrial diseases MELAS and LHON.FEBS Lett1998
9295316The involvement of serine 175 and alanine 185 of cytochrome b of Rhodobacter sphaeroides cytochrome bc1 complex in interaction with iron-sulfur protein.J Biol Chem1997
7499386The involvement of threonine 160 of cytochrome b of Rhodobacter sphaeroides cytochrome bc1 complex in quinone binding and interaction with subunit IV.J Biol Chem1995
7657607Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8.J Biol Chem1995
7737520An enhanced broad-host-range vector for gram-negative bacteria: avoiding tetracycline phototoxicity during the growth of photosynthetic bacteria.Gene1995
8383670Cytochrome oxidase genes from Thermus thermophilus. Nucleotide sequence of the fused gene and analysis of the deduced primary structures for subunits I and III of cytochrome caa3.J Biol Chem1993
8510555Recovery and cloning of genomic DNA fragments from dried agarose gels.Methods Enzymol1993
8457586Molecular modeling studies on the proposed NaCl-induced dimerization of Chromatium vinosum high-potential iron protein.Biochim Biophys Acta1993
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Collaborators

Akhil B Vaidya
Center for Molecular Parasitology, Drexel University College of Medicine
Co-authored papers 33
Geoffrey I McFadden
The University of Melbourne
Co-authored papers 2
Tian Tian
Beijing Friendship Hospital, Capital Medical University
Co-authored papers 2
David S Roos
University of Pennsylvania
Co-authored papers 2
Benjamin A Garcia
University of Pennsylvania
Co-authored papers 2
Joshua D Rabinowitz
Lewis Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 2
Ian T Paulsen
Macquarie University
Co-authored papers 1
Gopinath M Subramanian
John Hunter Children's Hospital
Co-authored papers 1
Jonathan A Eisen
McLean Hospital
Co-authored papers 1
Sue Kyes
Weatherall Institute of Molecular Medicine
Co-authored papers 1
Jonathan H Badger
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Milton H Saier
University of California at San Diego
Co-authored papers 1
Dhanasekaran Shanmugam
CSIR - National Chemical Laboratory
Co-authored papers 1
Alister G Craig
Malawi-Liverpool-Wellcome Trust Clinical Research Program
Co-authored papers 1
Bernard Suh
Center for Biomolecular Science and Engineering, University of California
Co-authored papers 1
Matthew Berriman
Wellcome Sanger Institute
Co-authored papers 1
Keith D James
Wellcome Trust Sanger Institute
Co-authored papers 1
Kim Rutherford
University of Cambridge
Co-authored papers 1
Martin Fraunholz
Julius-Maximilians-Universitat Wurzburg
Co-authored papers 1
Man-Suen Chan
University of Oxford
Co-authored papers 1
Leda M Cummings
Institute for Genome Research
Co-authored papers 1
Jeremy D Selengut
Craig Venter Institute, 9704 Medical Center Drive
Co-authored papers 1
David M A Martin
University of Dundee
Co-authored papers 1
Stuart A Ralph
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1
Samuel V Angiuoli
Personal Genome Diagnostics Inc.
Co-authored papers 1
Jeremy Peterson
The Institute for Genomic Research, 9712 Medical Center Drive
Co-authored papers 1
Claire M Fraser
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 1
Jane M Carlton
Center for Genomics and Systems Biology
Co-authored papers 1
Daniel H Haft
National Center for Biotechnology Information, National Institutes of Health
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Richard W Hyman
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