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Author Details

Oscar M Tirado
Institut d'Investigacio Biomedica de Bellvitge (IDIBELL)/CIBERONC
2000
66
30
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36603685Low Bcl-2 is a robust biomarker of sensitivity to nab-paclitaxel in Ewing sarcoma.Biochem Pharmacol2023
37251690Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors.Mol Ther Nucleic Acids2023
34974029SPARC-mediated long-term retention of nab-paclitaxel in pediatric sarcomas.J Control Release2022
35712255Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response.Front Endocrinol (Lausanne)2022
35354905Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1.Oncogene2022
33479225Sarcoma classification by DNA methylation profiling.Nat Commun2021
33982741Harnessing subcellular-resolved organ distribution of cationic copolymer-functionalized fluorescent nanodiamonds for optimal delivery of active siRNA to a xenografted tumor in mice.Nanoscale2021
33326104Metastasis Assessment in Ewing Sarcoma Using Orthotopic Xenografts.Methods Mol Biol2021
33097530RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis.Sci Adv2020
31963599Exosomes in Bone Sarcomas: Key Players in Metastasis.Cells2020
31911079LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of its catalytic activity.Cancer Lett2020
30846724Bcl-x<sub>L</sub> inhibition enhances Dinaciclib-induced cell death in soft-tissue sarcomas.Sci Rep2019
31484926The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition.Nat Commun2019
31167577Targeting fusion proteins: a double edge sword?Expert Opin Ther Targets2019
29177953Phase II Study of Gemcitabine Plus Sirolimus in Previously Treated Patients with Advanced Soft-Tissue Sarcoma: a Spanish Group for Research on Sarcomas (GEIS) Study.Target Oncol2018
29881993Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.Acta Neuropathol2018
30094618Correction to: DNA methylation-based reclassification of olfactory neuroblastoma.Acta Neuropathol2018
30140378The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma.Oncotarget2018
29730775DNA methylation-based reclassification of olfactory neuroblastoma.Acta Neuropathol2018
29582409EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma.Int J Cancer2018
27894957DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.Cancer Lett2017
28672777Correction: The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.Oncotarget2017
28881358Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.Br J Cancer2017
28832268DNA methylation profiling opens a new phase in the search of targeted therapy against Ewing sarcoma.Pharmacogenomics2017
26802024The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.Oncotarget2016
26563256Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS).Cancer Chemother Pharmacol2016
27317769RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein.Oncotarget2016
27315524The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report.Clin Sarcoma Res2016
27487136Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway.Oncotarget2016
25586480Sirolimus plus gemcitabine: a new therapeutic combination for resistant sarcomas?Expert Rev Anticancer Ther2015
26286475Cell Death Identification in Anticancer Therapy-Response.Cancer Res2015
26056084The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.Oncotarget2015
25905041The importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy.Front Oncol2015
25724677"(Not) all (dead) things share the same breath": identification of cell death mechanisms in anticancer therapy.Cancer Res2015
25804122Desmoplastic small round cell tumor 20 years after its discovery.Future Oncol2015
23801301Phase I trial of sorafenib in combination with ifosfamide in patients with advanced sarcoma: a Spanish group for research on sarcomas (GEIS) study.Invest New Drugs2014
25281719Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.Cancer Res2014
25313138Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth.Oncotarget2014
25003665Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours.Br J Cancer2014
23951165EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1.PLoS One2013
23857410The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma.Int J Oncol2013
22701332Targeted therapies in sarcomas: challenging the challenge.Sarcoma2012
21471610Caveolin-1 in sarcomas: friend or foe?Oncotarget2011
219114562-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma.Cancer Res2011
21373757Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells.Int J Oncol2011
19609943Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKCalpha phosphorylation.Int J Cancer2010
21106507Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize.Mol Cancer Res2010
19128055Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.J Med Chem2009
19117992PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.Cancer Res2009
17804748Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.Cancer Res2007
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Collaborators

Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu
Co-authored papers 18
Servicio de Anatomia Patologica. Hospital Universitario Virgen del Rocio.
Co-authored papers 16
Co-authored papers 6
University Medical Center Hamburg-Eppendorf
Co-authored papers 4
St. Anna Children's Cancer Research Institute (CCRI), Medical University Vienna
Co-authored papers 4
Co-authored papers 4
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 4
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 4
IRCCS Istituto Ortopedico Rizzoli
Co-authored papers 4
Co-authored papers 3
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
University Hospital Essen, West German Cancer Center
Co-authored papers 3
Universitatsspital Basel
Co-authored papers 3
Charite University Medicine Berlin
Co-authored papers 3
University College London, Cancer Institute
Co-authored papers 2
Seattle Children's Research Institute
Co-authored papers 2
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 2
Instituto de Salud Carlos III
Co-authored papers 2
University Medical Center Hamburg-Eppendorf
Co-authored papers 2
Nantes Universite, Inserm UMR 7, CNRS UMR 6075, Universite d'Angers
Co-authored papers 2
German Cancer Research Center
Co-authored papers 2
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Cancer Center of Lyon
Co-authored papers 2
University Hospital Erlangen
Co-authored papers 2
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Hopp Children's Cancer Center Heidelberg (KiTZ)
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Institute of Biology, Leiden University
Co-authored papers 2
Hopp Children's Cancer Center Heidelberg (KiTZ)
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Children's Cancer Research Center
Co-authored papers 2
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 2