Author details

Full Name

FranÃ§ois Aguet

Affiliation

ORCID

Career Start Year

2005

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37498674	Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.	J Clin Invest	2023
37601969	Multiset correlation and factor analysis enables exploration of multi-omics data.	Cell Genom	2023
37662416	Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies.	bioRxiv	2023
37961187	Placental RNA sequencing implicates IGFBP1 in insulin sensitivity during pregnancy and in gestational diabetes.		2023
37868038	The functional impact of rare variation across the regulatory cascade.	Cell Genom	2023
37864851	Higher Maternal Body Mass Index is associated with Lower Placental Expression of EPYC: A Genome-Wide Transcriptomic Study.		2023
37770633	Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease.	Nat Genet	2023
37216410	Canonical correlation analysis for multi-omics: Application to cross-cohort analysis.	PLoS Genet	2023
37205491	The landscape of tolerated genetic variation in humans and primates.	bioRxiv	2023
37205493	Rare penetrant mutations confer severe risk of common diseases.	medRxiv	2023
37262156	The landscape of tolerated genetic variation in humans and primates.	Science	2023
36698131	Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.	Respir Res	2023
37443254	Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.	Nat Genet	2023
36993312	Genetic regulation of fetal hemoglobin across global populations.	medRxiv	2023
36463326	Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.	Int J Obes (Lond)	2023
37425716	Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects.	bioRxiv	2023
35243413	Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.	Cell Rep Med	2022
35705541	Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.	Nat Commun	2022
36282911	Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.	Sci Signal	2022
35802025	FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits.	Cancer Res	2022
35549429	Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function.	Science	2022
35927489	Molecular map of chronic lymphocytic leukemia and its impact on outcome.	Nat Genet	2022
35922514	RNA editing underlies genetic risk of common inflammatory diseases.	Nature	2022
35922509	Transcriptome variation in human tissues revealed by long-read sequencing.	Nature	2022
36396631	Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis.	Nat Commun	2022
36379208	Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma.	Cancer Cell	2022
35716666	Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.	Am J Hum Genet	2022
36777183	The landscape of expression and alternative splicing variation across human traits.	Cell Genom	2022
34663921	Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer.	Nat Biotechnol	2022
35100260	Transcription factor regulation of eQTL activity across individuals and tissues.	PLoS Genet	2022
35087136	Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.	Sci Rep	2022
33203734	The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.	Cancer Discov	2021
34015820	Benchmarking association analyses of continuous exposures with RNA-seq in observational studies.	Brief Bioinform	2021
33677499	RNA-SeQC 2: efficient RNA-seq quality control and quantification for large cohorts.	Bioinformatics	2021
33658504	A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction.	Nature Communications	2021
33499903	Exploiting the GTEx resources to decipher the mechanisms at GWAS loci.	Genome Biol	2021
32912314	sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression.	Genome Biol	2020
32403949	Transcriptional and Cellular Diversity of the Human Heart.	Circulation	2020
32442065	Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression.	J Clin Oncol	2020
32964524	Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification.	Genetic Epidemiology	2020
32913075	Cell type-specific genetic regulation of gene expression across human tissues.	Science	2020
32913074	Determinants of telomere length across human tissues.	Science	2020
32913072	The impact of sex on gene expression across human tissues.	Science	2020
32912332	A vast resource of allelic expression data spanning human tissues.	Genome Biol	2020
32912333	Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.	Genome Biol	2020
31068700	Next-generation characterization of the Cancer Cell Line Encyclopedia.	Nature	2019
31745334	Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.	Nat Med	2019
31675989	Scaling computational genomics to millions of individuals with GPUs.	Genome Biol	2019
31501609	Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.	Nat Med	2019
31171663	RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues.	Science	2019