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Author Details

David E Larson
McDonnell Genome Institute, Washington University School of Medicine
2003
62
43
PMIDPaper TitleJournal TitlePublished Year
34341766Bam-readcount - rapid generation of basepair-resolution sequence metrics.ArXiv2021
33798444Association of structural variation with cardiometabolic traits in Finns.Am J Hum Genet2021
34099068Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.Hum Genomics2021
32577507The clonal evolution of metastatic colorectal cancer.Sci Adv2020
31218349svtools: population-scale analysis of structural variation.Bioinformatics2019
31686056Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power.Nature2019
31367044Exome sequencing of Finnish isolates enhances rare-variant association power.Nature2019
30279509Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects.Nat Commun2018
30181556The prognostic effects of somatic mutations in ER-positive breast cancer.Nat Commun2018
30429476Author Correction: The prognostic effects of somatic mutations in ER-positive breast cancer.Nat Commun2018
27788309Brief Report: The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis.Arthritis Rheumatol2017
28138153CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.Nat Genet2017
29184913The Alzheimer's Disease Sequencing Project: Study design and sample selection.Neurol Genet2017
28760689Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.Exp Hematol2017
27029710A genomic case study of mixed fibrolamellar hepatocellular carcinoma.Ann Oncol2016
27681435Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas.Cell Rep2016
27502118Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers.Nat Commun2016
27486019Rare Variation in TET2 Is Associated with Clinically Relevant Prostate Carcinoma in African Americans.Cancer Epidemiol Biomarkers Prev2016
27181063Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.Exp Hematol2016
25704602Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci.Am J Hum Genet2015
26305651Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.JAMA2015
26645048Optimizing cancer genome sequencing and analysis.Cell Syst2015
26441179Effect of Laparoscopic-Assisted Resection vs Open Resection of Stage II or III Rectal Cancer on Pathologic Outcomes: The ACOSOG Z6051 Randomized Clinical Trial.JAMA2015
26689913Patterns and functional implications of rare germline variants across 12 cancer types.Nat Commun2015
26158448Genome Modeling System: A Knowledge Management Platform for Genomics.PLoS Comput Biol2015
25849893TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.PLoS One2015
24497850Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.PLoS Genet2014
25431635Using SomaticSniper to Detect Somatic Single Nucleotide Variants.Curr Protoc Bioinformatics2014
25152801BreakDancer: Identification of Genomic Structural Variation from Paired-End Read Mapping.Curr Protoc Bioinformatics2014
24560519Exome-based mapping and variant prioritization for inherited Mendelian disorders.Am J Hum Genet2014
24448499Integrated analysis of germline and somatic variants in ovarian cancer.Nat Commun2014
23634996Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.N Engl J Med2013
25553206Using VarScan 2 for Germline Variant Calling and Somatic Mutation Detection.Curr Protoc Bioinformatics2013
24074859The next-generation sequencing revolution and its impact on genomics.Cell2013
24122041DGIdb: mining the druggable genome.Nat Methods2013
24036949Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.Nat Genet2013
24055055Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.Cell Rep2013
22155872SomaticSniper: identification of somatic point mutations in whole genome sequencing data.Bioinformatics2012
22817890The origin and evolution of mutations in acute myeloid leukemia.Cell2012
22542160Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.Cell Stem Cell2012
22300766VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.Genome Res2012
22237025Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.Nature2012
22228022Massively parallel sequencing approaches for characterization of structural variation.Methods Mol Biol2012
22417201Clonal architecture of secondary acute myeloid leukemia.N Engl J Med2012
21505136Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.JAMA2011
22158538Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.Nat Genet2011
21436584Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.J Clin Invest2011
20031968CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data.Bioinformatics2010
21067377DNMT3A mutations in acute myeloid leukemia.N Engl J Med2010
20617161Computer simulation of cellular patterning within the Drosophila pupal eye.PLoS Comput Biol2010
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Collaborators

Richard K Wilson
The Ohio State University
Co-authored papers 43
Elaine R Mardis
The Ohio State University
Co-authored papers 38
Robert S Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 32
Daniel C Koboldt
Institute for Genomic Medicine, Nationwide Children's Hospital
Co-authored papers 29
Li Ding
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 26
Timothy J Ley
Washington University School of Medicine
Co-authored papers 22
Christopher A Miller
Washington University School of Medicine
Co-authored papers 20
Michael D McLellan
McDonnell Genome Institute, Washington University in St. Louis
Co-authored papers 19
Ken Chen
University of Texas MD Anderson Cancer Center
Co-authored papers 18
Vincent Magrini
The Ohio State University
Co-authored papers 16
Malachi Griffith
Washington University
Co-authored papers 14
Obi L Griffith
Washington University
Co-authored papers 14
Timothy A Graubert
Massachusetts General Hospital
Co-authored papers 13
Joshua F McMichael
Washington University
Co-authored papers 13
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 12
Lucinda Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 12
Sean McGrath
Harvard T.H. Chan School of Public Health
Co-authored papers 12
Jason Walker
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 12
Daniel C Link
Washington University School of Medicine
Co-authored papers 11
Sharon E Heath
Washington University School of Medicine.
Co-authored papers 11
Qunyuan Zhang
Co-authored papers 11
Matthew J Walter
Washington University School of Medicine in St. Louis
Co-authored papers 11
John F DiPersio
Washington University School of Medicine
Co-authored papers 11
Jacqueline E Payton
Washington University School of Medicine.
Co-authored papers 10
Peter Westervelt
Washington University School of Medicine
Co-authored papers 10
Michelle O'Laughlin
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 10
Mark A Watson
Washington University School of Medicine
Co-authored papers 10
Michael C Wendl
Washington University in St Louis
Co-authored papers 9
James M Eldred
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 9
Kilannin Krysiak
Washington University School of Medicine
Co-authored papers 8
Release 1.2