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Author Details

Timothy D O'Connell
1994
51
26
PMIDPaper TitleJournal TitlePublished Year
37230379Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.2023
37285607Genome-wide association study of Red Blood Cell fatty acids in the Women's Health Initiative Memory Study.Prostaglandins Leukot Essent Fatty Acids2023
37075982FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome.2023
36734200Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy.Aging Cell2023
34859913Guanylyl cyclase-A phosphorylation decreases cardiac hypertrophy and improves systolic function in male, but not female, mice.FASEB J2022
36167357Comment on "Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice".Journal of Immunology2022
35944007Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease.Physiology2022
36340689Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases.Front Mol Neurosci2022
33752243Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload.Cardiovasc Res2022
34368512Murine Ischemia Reperfusion Without Endotracheal Intubation or Ventilation: A Tutorial.JACC: Basic to Translational Science2021
33061864Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites.Eur Heart J Suppl2020
31302044Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids: From MESA.JACC: Heart Failure2019
30528765ERK mediated survival signaling is dependent on the Gq-G-protein coupled receptor type and subcellular localization in adult cardiac myocytes.Journal of Molecular and Cellular Cardiology2019
29610273Subcellular compartmentalization of proximal Gα-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes.Journal of Biological Chemistry2018
27986444Ͽ3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4.Journal of Molecular and Cellular Cardiology2017
27688302With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time.Circulation Research2016
26435012EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4.Journal of Lipid Research2015
25551323A nuclear option? G-protein coupled receptors at the nucleus in cardiac myocytes.Journal of Cardiovascular Pharmacology2015
25264754Nuclear compartmentalization of α1-adrenergic receptor signaling in adult cardiac myocytes.Journal of Cardiovascular Pharmacology2015
25304347Quantification of catecholamine uptake in adult cardiac myocytes.Methods in Molecular Biology2015
25420485Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast.Circ Heart Fail2015
24703911Promising small molecule for heart failure targeting adrenal catecholamine release and β-adrenergic receptor signaling in the heart.J Am Coll Cardiol2014
24145181Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation.Journal of Cardiovascular Pharmacology2014
24368739Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.Pharmacological Reviews2014
24772522Nuclear localization of a1A-adrenergic receptors is required for signaling in cardiac myocytes: an ⿿inside-out⿝ a1-AR signaling pathway.Journal of the American Heart Association2014
22120526Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes.Cellular Signalling2012
21282499Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts.Circulation2011
21118696Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.Journal of Molecular and Cellular Cardiology2011
20692266An association between gene expression and better survival in female mice following myocardial infarction.Journal of Molecular and Cellular Cardiology2010
18552157GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling.American Journal of Physiology - Heart and Circulatory Physiology2008
18802028Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.Circulation Research2008
17525155Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury.Journal of Biological Chemistry2007
17283256An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes.Circulation2007
17172694Isolation and culture of adult mouse cardiac myocytes.Methods in Molecular Biology2007
17395699Rapamycin prevents thyroid hormone-induced cardiac hypertrophy.Endocrinology2007
16585965Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.J Clin Invest2006
15599842Aldosterone directly stimulates cardiac myocyte hypertrophy.Journal of Cardiac Failure2004
12595294Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR.American Journal of Physiology - Heart and Circulatory Physiology2003
14519431Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice.Journal of Molecular and Cellular Cardiology2003
12782680The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.J Clin Invest2003
12478301Overview of the Alliance for Cellular Signaling.Nature2002
12234770Alpha(1)-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha(1A/C)-knockout and wild type mice.Journal of Molecular and Cellular Cardiology2002
11306707Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1).Molecular Pharmacology2001
9677384Antisense oligonucleotides targeted against protein kinase Cbeta and CbetaII block 1,25-(OH)2D3-induced differentiation.Journal of Biological Chemistry1998
91399591,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy.American Journal of Physiology1997
9354591Promotion of HL-60 cell differentiation by 1,25-dihydroxyvitamin D3 regulation of protein kinase C levels and activity.Biochemical Pharmacology1997
88284711,25-Dihydroxyvitamin D3-regulated binding of nuclear proteins to a c-myc intron element.Endocrinology1996
8948124Immunochemical identification of the 1,25-dihydroxyvitamin D3 receptor protein in human heart.Cell Biology International1996
76397621,25-Dihydroxyvitamin D3 regulation of myocardial growth and c-myc levels in the rat heart.Biochemical and Biophysical Research Communications1995
7835280Inhibition of cardiac myocyte maturation by 1,25-dihydroxyvitamin D3.Endocrinology1995
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