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Author Details

Morgan L Maeder
Massachusetts General Hospital, Harvard Medical School
2007
42
31
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
30358434Somatic Gene Editing of <i>GUCY2D</i> by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque.Hum Gene Ther2019
31884594In Vivo Assessment of Potential Therapeutic Approaches for USH2A-Associated Diseases.Adv Exp Med Biol2019
30664785Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10.Nat Med2019
29562890UDiTaSâ¿¢, a genome editing detection method for indels and genome rearrangements.BMC Genomics2018
29600989Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".Nat Methods2018
26755333Genome-editing Technologies for Gene and Cell Therapy.Mol Ther2016
25357182Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.Nat Biotechnol2015
26596280Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications.Genome Biol2015
26068008Delivery and Specificity of CRISPR-Cas9 Genome Editing Technologies for Human Gene Therapy.Hum Gene Ther2015
26000857Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.PLoS Genet2015
24704492Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.Cell Stem Cell2014
24782510Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.Blood2014
23360964Efficient genome editing in zebrafish using a CRISPR-Cas system.Nat Biotechnol2013
24108092Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.Nat Biotechnol2013
23821439Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly.Curr Protoc Mol Biol2013
23874735Heritable and precise zebrafish genome editing using a CRISPR-Cas system.PLoS One2013
23892898CRISPR RNA-guided activation of endogenous human genes.Nat Methods2013
23792628High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.Nat Biotechnol2013
23396285Robust, synergistic regulation of human gene expression using TALE activators.Nat Methods2013
23546300TALEN-based gene correction for epidermolysis bullosa.Mol Ther2013
22970113Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos.PLoS One2012
21151135Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).Nat Methods2011
21987054Engineering designer nucleases with customized cleavage specificities.Curr Protoc Mol Biol2011
21818254Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.PLoS One2011
21898685In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.Stem Cells2011
21631241Zinc-finger nucleases for somatic gene therapy: the next frontier.Hum Gene Ther2011
20435679ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.Nucleic Acids Res2010
21044337Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences.BMC Bioinformatics2010
20716517Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.Nucleic Acids Res2010
20680826Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.Methods Mol Biol2010
20508152High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.Proc Natl Acad Sci U S A2010
18812396Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.Nucleic Acids Res2009
20010934Targeted mutagenesis in zebrafish using customized zinc-finger nucleases.Nat Protoc2009
19798082Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays.Nat Protoc2009
19404258High-frequency modification of plant genes using engineered zinc-finger nucleases.Nature2009
19348652Differential expression of the Enhancer of split genes in the developing Drosophila midgut.Hereditas2009
19540188Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.Cell Stem Cell2009
19198653Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).PLoS One2009
18334988Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.Mol Ther2008
18657511Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.Mol Cell2008
18039873Phylogenetic footprinting analysis in the upstream regulatory regions of the Drosophila enhancer of split genes.Genetics2007
17994088Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.Nature2007
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Collaborators

J Keith Joung
Massachusetts General Hospital
Co-authored papers 31
Stacey Thibodeau-Beganny
Amherst College
Co-authored papers 8
Christopher J Wilson
Co-authored papers 3
Shondra M Pruett-Miller
St. Jude Children's Research Hospital.
Co-authored papers 3
Vic E Myer
Co-authored papers 3
Matthew H Porteus
Stanford University
Co-authored papers 3
Dennis C Sgroi
Co-authored papers 2
Tim Fennell
Co-authored papers 2
Madeline A Crosby
Harvard University
Co-authored papers 1
David M Langenau
MGH Pathology and Harvard Medical School
Co-authored papers 1
George M Church
Harvard Medical School
Co-authored papers 1
Vittorio Sebastiano
Stanford University
Co-authored papers 1
Bassem T Elhassan
Co-authored papers 1
Jacques van Helden
Co-authored papers 1
Ultan McDermott
Wellcome Sanger Institute
Co-authored papers 1
Manolis Kellis
Massachusetts Institute of Technology
Co-authored papers 1
Megan J Riddle
Department of Pediatrics and the Masonic Cancer Center, University of Minnesota
Co-authored papers 1
Don Gilbert
Indiana University
Co-authored papers 1
Susan E Celniker
Lawrence Berkeley National Laboratory
Co-authored papers 1
William James Kent
Co-authored papers 1
Kevin Eggan
Co-authored papers 1
Prashant Mali (CM4AI)
University of California San Diego
Co-authored papers 1
In-Hyun Park
Yale School of Medicine
Co-authored papers 1
Benedict Paten
UC Santa Cruz Genomics Institute, University of California
Co-authored papers 1
David R Liu
Co-authored papers 1
Linzhao Cheng
Johns Hopkins University School of Medicine
Co-authored papers 1
Joseph F Costello
University of California san francisco
Co-authored papers 1
Colin N Dewey
Co-authored papers 1
Anthony J Iafrate
Massachusetts General Hospital
Co-authored papers 1
Bradley E Bernstein
Broad Institute of MIT and Harvard
Co-authored papers 1
Release 1.2