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Author Details

David Uehling
Ontario Institute for Cancer Research, University Avenue
1989
47
24
PMIDPaper TitleJournal TitlePublished Year
36793435Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.ACS Med Chem Lett2023
37712569Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation.Cancer Discov2023
37660910G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.J Biol Chem2023
37354357An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.J Neurooncol2023
37075613Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels.Biomaterials2023
34963044Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma".J Med Chem2022
36030052G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.J Biol Chem2022
35089724Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.J Med Chem2022
34291633Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.J Med Chem2021
33542074Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.Clin Cancer Res2021
34589290The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.Oncoimmunology2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
33939407Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.J Med Chem2021
32778845Functional characterization of a PROTAC directed against BRAF mutant V600E.Nat Chem Biol2020
32094923A drug discovery platform to identify compounds that inhibit EGFR triple mutants.Nat Chem Biol2020
30696771Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.J Biol Chem2019
26952093PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.J Transl Med2016
27618721Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay.Stem Cell Reports2016
27449082Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.Oncotarget2016
26916338Small molecules reveal an alternative mechanism of Bax activation.Biochem J2016
27006494Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.Clin Cancer Res2016
26298497Recent progress on MAP kinase pathway inhibitors.Bioorg Med Chem Lett2015
24487029shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.Cancer Res2014
25330770Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.EMBO Mol Med2014
25164867Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.Nat Commun2014
23844038Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions.PLoS One2013
24900673Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors.ACS Med Chem Lett2013
23830192New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia.Radiother Oncol2013
22700489Use of kinase inhibitors to correct οF508-CFTR function.Mol Cell Proteomics2012
23074266TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.Sci Signal2012
21303981Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.Cancer Res2011
22014571Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.Cancer Cell2011
21733693Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup.Bioorg Med Chem Lett2011
19028424Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors.Bioorg Med Chem Lett2009
19111461Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.Bioorg Med Chem Lett2009
19101143Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).Bioorg Med Chem Lett2009
19208477Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors.Bioorg Med Chem Lett2009
182870366-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.Proc Natl Acad Sci U S A2008
18842405Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines.Bioorg Med Chem Lett2008
17560786Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.Bioorg Med Chem Lett2007
16640337Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.J Med Chem2006
16483772Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors.Bioorg Med Chem Lett2006
11806709Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.J Med Chem2002
11112653Two general routes to 1,4-disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines.Org Lett2000
7707314Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.J Med Chem1995
7834631In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues.Cancer Res1995
2477715A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase.Nature1989
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Collaborators

Ontario Institute for Cancer Research, University Avenue
Co-authored papers 22
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Co-authored papers 12
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 11
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 9
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 9
University of Perugia
Co-authored papers 5
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 4
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 3
University Health Network, University of Toronto
Co-authored papers 3
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 2
Princess Margaret Cancer Centre University Health Network
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 2
University of Toronto
Co-authored papers 2
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Hospital for Sick Children
Co-authored papers 2
Sunnybrook Research Institute, University of Toronto
Co-authored papers 2
the Second Hospital, Cheeloo College of Medicine, Shandong University
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
Princess Margaret Cancer Center, University Health Network, University of Toronto
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
University of British Columbia
Co-authored papers 1
University of Glasgow
Co-authored papers 1
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
University of British Columbia
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University of British Columbia
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Institute for Research in Immunology and Cancer, Universite de Montreal
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The Hospital for Sick Children Research Institute
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McMaster University
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University of British Columbia
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Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1