Author details

Full Name

David M MacAlpine

Affiliation

ORCID

Career Start Year

1994

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37292814	Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase.		2023
38081658	Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase.		2023
34946946	Cell-Cycle-Dependent Chromatin Dynamics at Replication Origins.	Genes	2021
33893157	Linking the dynamics of chromatin occupancy and transcription with predictive models.	Genome Research	2021
34270943	Stochastic initiation of DNA replication across the human genome.	Molecular Cell	2021
34556529	Disruption of origin chromatin structure by helicase activation in the absence of DNA replication.	Genes and Development	2021
34386808	RoboCOP: Multivariate State Space Model Integrating Epigenomic Accessibility Data to Elucidate Genome-Wide Chromatin Occupancy.		2020
32286309	Capturing the primordial Kras mutation initiating urethane carcinogenesis.	Nature Communications	2020
31217252	Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork.	Genome Research	2019
31083663	Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats.	PLoS Genetics	2019
30279224	Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in <i>Drosophila</i>.	Genome Res	2018
27924004	Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization.	Nucleic Acids Res	2017
28322723	Nucleosomes influence multiple steps during replication initiation.	eLife	2017
27496327	ORChestrating the human DNA replication program.	Proceedings of the National Academy of Sciences of the United States of America	2016
27141053	Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.	Mol Cell Biol	2016
27131378	Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.	Nucleic Acids Research	2016
27542827	DNA replication origins-where do we begin?	Genes and Development	2016
25555795	Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.	EMBO Journal	2015
25593310	Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly.	Genes and Development	2015
25870112	Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.	Molecular and Cellular Biology	2015
25437878	Rare codons capacitate Kras-driven de novo tumorigenesis.	Journal of Clinical Investigation	2015
25860614	SnapShot: Origins of DNA replication.	Cell	2015
25164756	Comparative analysis of metazoan chromatin organization.	Nature	2014
25262759	DNA copy number evolution in Drosophila cell lines.	Genome Biol	2014
25217194	Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.	Genome Res	2014
24985913	DNA replication and transcription programs respond to the same chromatin cues.	Genome Research	2014
23246410	Rare codons regulate KRas oncogenesis.	Curr Biol	2013
23751185	Chromatin and DNA replication.	Cold Spring Harbor perspectives in biology	2013
22090375	Developmental control of gene copy number by repression of replication initiation and fork progression.	Genome Research	2012
22972499	Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.	Developmental Dynamics	2012
22465279	Genome-wide localization of replication factors.	Methods	2012
22025700	Epigenome characterization at single base-pair resolution.	Proc Natl Acad Sci U S A	2011
21430782	A cis-regulatory map of the Drosophila genome.	Nature	2011
21417598	Defining the replication program through the chromatin landscape.	Critical Reviews in Biochemistry and Molecular Biology	2011
21179089	Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.	Nature	2011
21177973	Chromatin signatures of the Drosophila replication program.	Genome Research	2011
21177957	Developmental control of the DNA replication and transcription programs.	Genome Research	2011
21724831	Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.	Genes and Development	2011
20090829	Co-orientation of replication and transcription preserves genome integrity.	PLoS Genetics	2010
20838463	Preferential re-replication of Drosophila heterochromatin in the absence of geminin.	PLoS Genetics	2010
21177974	Identification of functional elements and regulatory circuits by Drosophila modENCODE.	Science	2010
20351051	Conserved nucleosome positioning defines replication origins.	Genes and Development	2010
19996087	Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.	Genome Research	2010
20595233	The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin.	Genes and Development	2010
20186269	Expression in aneuploid Drosophila S2 cells.	PLoS Biology	2010
19536255	Unlocking the secrets of the genome.	Nature	2009
18007591	Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.	EMBO J	2007
17940024	Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation.	Proceedings of the National Academy of Sciences of the United States of America	2007
17978103	Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.	Genes Dev	2007
16525018	Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation.	Molecular Biology of the Cell	2006