|
| 37545094 | Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor. | Ann Clin Transl Neurol | 2023 |
| 37399505 | Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes. | | 2023 |
| 37127662 | A highly efficient transgene knock-in technology in clinically relevant cell types. | | 2023 |
| 33876962 | CALITAS: A CRISPR-Cas-aware ALigner for off-TArget Search. | CRISPR Journal | 2021 |
| 31942029 | Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles. | Commun Biol | 2020 |
| 31955578 | Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders. | Journal of Medicinal Chemistry | 2020 |
| 30664785 | Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10. | Nat Med | 2019 |
| 31225747 | Identification of Guide-Intrinsic Determinants of Cas9 Specificity. | CRISPR Journal | 2019 |
| 29600989 | Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". | Nat Methods | 2018 |
| 30154463 | Publisher Correction: Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells. | Nat Commun | 2018 |
| 30054474 | Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells. | Nat Commun | 2018 |
| 30004693 | Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. | Biochemistry | 2018 |
| 29562890 | UDiTaSâ¿¢, a genome editing detection method for indels and genome rearrangements. | BMC Genomics | 2018 |
| 28042708 | Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis | 2017 |
| 27899692 | Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform. | SLAS Discovery | 2017 |
| 26562506 | Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? | Journal of Molecular Biology | 2016 |
| 26731447 | Correction: Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages. | PLoS ONE | 2016 |
| 27159400 | Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism. | JAMA Neurol | 2016 |
| 26378449 | Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages. | PLoS ONE | 2015 |
| 26364931 | Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression. | | 2015 |
| 24608574 | Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. | Mol Cancer Ther | 2014 |
| 25327288 | Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. | Nature Cell Biology | 2014 |
| 24474669 | Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. | Clinical Cancer Research | 2014 |
| 24904423 | In vitro clinical trials: the future of cell-based profiling. | Frontiers in Pharmacology | 2014 |
| 23613971 | The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. | PLoS ONE | 2013 |
| 23890009 | PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. | | 2013 |
| 23184937 | Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. | Journal of Biological Chemistry | 2013 |
| 22125069 | Quantitative visualization of autophagy induction by mTOR inhibitors. | Methods in Molecular Biology | 2012 |
| 22653967 | Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations. | Molecular Cancer Therapeutics | 2012 |
| 22970117 | Identification of elongation factor G as the conserved cellular target of argyrin B. | PLoS ONE | 2012 |
| 22460905 | The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. | Nature | 2012 |
| 22874768 | Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. | Cancer Discovery | 2012 |
| 23002168 | FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. | Cancer Discov | 2012 |
| 22188813 | Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. | Molecular Cancer Therapeutics | 2012 |
| 21576371 | Relieving autophagy and 4EBP1 from rapamycin resistance. | Molecular and Cellular Biology | 2011 |
| 21107320 | COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. | Nature | 2010 |
| 19759537 | Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. | Nature | 2009 |
| 19203585 | Bidirectional transport of amino acids regulates mTOR and autophagy. | Cell | 2009 |
| 19605471 | Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. | Journal of Virology | 2009 |
| 16426056 | Visualization and interpretation of high content screening data. | Journal of Chemical Information and Modeling | 2006 |
| 16257201 | Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors. | Bioorganic and Medicinal Chemistry Letters | 2006 |
| 16398546 | Design and synthesis of a quinazolinone natural product-templated library with cytotoxic activity. | | 2006 |
| 16289814 | Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs. | Bioorganic and Medicinal Chemistry Letters | 2006 |
| 16234339 | Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method. | Journal of Biomolecular Screening | 2006 |
| 16125662 | Development of a high-throughput robotic fluorescence-based assay for HsEg5 inhibitor screening. | Analytical Biochemistry | 2005 |
| 16018661 | Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation. | Organic Letters | 2005 |
| 15140381 | Multiplex GPCR assay in reverse transfection cell microarrays. | Journal of Biomolecular Screening | 2004 |
| 11554723 | Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse. | Analytical Biochemistry | 2001 |
| 11125145 | Genome-wide location and function of DNA binding proteins. | Science | 2000 |
| 9702190 | Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. | Molecular Cell | 1998 |