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Author Details

Enzo Medico
Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO) - IRCCS
1988
128
44
PMIDPaper TitleJournal TitlePublished Year
36816936Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient.Front Oncol2023
37189167Multi-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity.Genome Med2023
37183363Dual VEGFA/BRAF targeting boosts PD-1 blockade in melanoma through GM-CSF-mediated infiltration of M1 macrophages.Mol Oncol2023
35314684A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.Nat Commun2022
35999193Successful treatment with MEK-inhibitor in a patient with NRAS-related cutaneous skeletal hypophosphatemia syndrome.Genes Chromosomes Cancer2022
36056393The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway.J Exp Clin Cancer Res2022
34359705Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.Cancers (Basel)2021
35052347MEK Inhibition in a Newborn with <i>RAF1</i>-Associated Noonan Syndrome Ameliorates Hypertrophic Cardiomyopathy but Is Insufficient to Revert Pulmonary Vascular Disease.Genes (Basel)2021
34439247The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells.Cancers (Basel)2021
34426441Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.Clin Cancer Res2021
34133926The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation.Cell Rep2021
32404931A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes.Lab Invest2020
31831554A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.Clin Cancer Res2020
32070860Patient-derived xenografts (PDXs) as model systems for human cancer.Curr Opin Biotechnol2020
33122354MiR-100 is a predictor of endocrine responsiveness and prognosis in patients with operable luminal breast cancer.ESMO Open2020
32826944Machine learning for RNA sequencing-based intrinsic subtyping of breast cancer.Sci Rep2020
32705585Associations between hypovitaminosis D and COVID-19: a narrative review.Aging Clin Exp Res2020
32759276Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.Sci Transl Med2020
32900797CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes.Clin Cancer Res2020
32521738Improved Outcome Prediction for Appendiceal Pseudomyxoma Peritonei by Integration of Cancer Cell and Stromal Transcriptional Profiles.Cancers (Basel)2020
30637502Predicting locally advanced rectal cancer response to neoadjuvant therapy with <sup>18</sup>F-FDG PET and MRI radiomics features.Eur J Nucl Med Mol Imaging2019
31585941A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits.Cancer Res2019
31375513Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.Clin Cancer Res2019
31431542Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells.Sci Signal2019
31287543Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research.Database (Oxford)2019
31253177Evolving neoantigen profiles in colorectal cancers with DNA repair defects.Genome Med2019
30981604A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.Clin Colorectal Cancer2019
28974546A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.Clin Cancer Res2018
30244122Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power.J Biomed Inform2018
29975246The Dilemma of HER2 Double-equivocal Breast Carcinomas: Genomic Profiling and Implications for Treatment.Am J Surg Pathol2018
30174307Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.Cell Metab2018
29412457Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies.J Pathol2018
29574251Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.Neoplasia2018
29346274IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.Cancers (Basel)2018
27974353VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.EMBO Mol Med2017
28277873Periodontal disease and women's health.Curr Med Res Opin2017
28104906Interrogating open issues in cancer precision medicine with patient-derived xenografts.Nat Rev Cancer2017
28100566Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.EMBO Mol Med2017
28349074Dysregulation of MS risk genes and pathways at distinct stages of disease.Neurol Neuroimmunol Neuroinflamm2017
29092942PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.Cancer Res2017
28912576Interrogating open issues in cancer medicine with patient-derived xenografts.Nat Rev Cancer2017
28561063Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.Nat Commun2017
28052020The RNA-binding protein ESRP1 promotes human colorectal cancer progression.Oncotarget2017
25804630The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.Gut2016
27681291Corrigendum: Stromal contribution to the colorectal cancer transcriptome.Nat Genet2016
27771609Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.J Natl Cancer Inst2016
27298830A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart.Biomed Res Int2016
26740323Long-term efficacy of microbiology-driven periodontal laser-assisted therapy.Eur J Clin Microbiol Infect Dis2016
26924269Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib.J Mol Cell Cardiol2016
25473895Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.Oncotarget2015
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Collaborators

Andrea Bertotti
Candiolo Cancer Institute - FPO IRCCS
Co-authored papers 26
Livio Trusolino
Candiolo Cancer Institute - FPO IRCCS
Co-authored papers 24
Francesco Galimi
Co-authored papers 11
Giorgio Inghirami
Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital
Co-authored papers 8
Caterina Marchi??
University of Turin, Candiolo Cancer Institute, FPO-IRCCS
Co-authored papers 8
Annette T Byrne
Royal College of Surgeons in Ireland (RCSI)
Co-authored papers 4
Carlos Caldas
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 3
Daniel S Peeper
Netherlands Cancer Institute
Co-authored papers 3
Diego Pasini
European Institute of Oncology IRCCS
Co-authored papers 3
Emilie Vinolo
CNRS URA 5
Co-authored papers 3
Alejandra Bruna
CRUK Cambridge Institute, University of Cambridge
Co-authored papers 3
Kristel Kemper
Oncode Institute, The Netherlands Cancer Institute
Co-authored papers 3
Oscar M Rueda
University of Cambridge
Co-authored papers 3
Els Hermans
Netherlands Cancer Institute
Co-authored papers 3
Fr??d??ric Amant
Netherlands Cancer Institute
Co-authored papers 3
Giovanni Battista Ferrero
Co-authored papers 3
Jos Jonkers
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 3
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Adam J Bass
Co-authored papers 2
Elisabetta Marangoni
Co-authored papers 2
Marco Tartaglia
Co-authored papers 2
Rodrigo Dienstmann
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus
Co-authored papers 2
Luigi Naldini
Vita-Salute San Raffaele University
Co-authored papers 2
Laura Cantini
Institut Pasteur, Universite Paris Cite, CNRS UMR 3738
Co-authored papers 2
Michele Caselle
University of Turin and INFN
Co-authored papers 2
Theodore C Goldstein
Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 1
Amanda L Christie
Dana-Farber Cancer Institute
Co-authored papers 1
Marcel Kool
Hopp Children's Cancer Center (KiTZ)
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Release 1.2