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Author Details

Yuh Min Chook
University of Texas Southwestern Medical Center
1991
69
36
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37214964Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.bioRxiv2024
36747879Molecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9.bioRxiv2023
37450495Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTPâ¿¢Kap114â¿¢H2A-H2B complex.Proc Natl Acad Sci U S A2023
37279758A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.Structure2023
37379840Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9.Structure2023
37463454A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.J Clin Invest2023
35058649Karyopherin-mediated nucleocytoplasmic transport.Nat Rev Mol Cell Biol2022
35412246Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1.Methods Mol Biol2022
35412243Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1.Methods Mol Biol2022
36103578Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.Proc Natl Acad Sci U S A2022
33451349Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.J Hematol Oncol2021
33580145Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).Sci Rep2021
33720780An update to the CRM1 cargo/NES database NESdb.Mol Biol Cell2021
31504173pCRM1exportome: database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes.Bioinformatics2020
33659298Molecular Size Analysis of Recombinant Importin-histone Complexes Using Analytical Ultracentrifugation.Bio Protoc2020
33300986Nuclear import of histones.Biochem Soc Trans2020
32474299Karyopherins and condensates.Curr Opin Cell Biol2020
32520643Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.Mol Biol Cell2020
30855230Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.Elife2019
31036839Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site.Sci Rep2019
29677512Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.Cell2018
29927350Correlation of CRM1-NES affinity with nuclear export activity.Mol Biol Cell2018
30538201Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.Proc Natl Acad Sci U S A2018
29728608Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization.Sci Rep2018
29610492Günter Blobel 1936-2018.Nat Struct Mol Biol2018
29414591Karyopherins in cancer.Curr Opin Cell Biol2018
29677513Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.Cell2018
28282025Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.Elife2017
27114554Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.Proc Natl Acad Sci U S A2016
27618664Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.Structure2016
27528606Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.J Biol Chem2016
27323910Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.Leukemia2016
25515756LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.Bioinformatics2015
26349033Structural determinants of nuclear export signal orientation in binding to exportin CRM1.Elife2015
26173234Nuclear localization signals for four distinct karyopherin-β nuclear import systems.Biochem J2015
25706475Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.Nat Neurosci2015
24478460Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration.Mol Biol Cell2014
24631835Atomic basis of CRM1-cargo recognition, release and inhibition.Semin Cancer Biol2014
22847027Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.Leukemia2013
23535894Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.J Struct Funct Genomics2013
23297231Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.Proc Natl Acad Sci U S A2013
22833564NESdb: a database of NES-containing CRM1 cargoes.Mol Biol Cell2012
23034282Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.Blood2012
22778397Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).Proc Natl Acad Sci U S A2012
22833565Sequence and structural analyses of nuclear export signals in the NESdb database.Mol Biol Cell2012
21029754Nuclear import by karyopherin-βs: recognition and inhibition.Biochim Biophys Acta2011
21965294Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.Mol Biol Cell2011
21665952Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP).J Biol Chem2011
20951026Recognition of nuclear targeting signals by Karyopherin-β proteins.Curr Opin Struct Biol2010
19366694Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus.J Biol Chem2009
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Collaborators

Ho Yee Joyce Fung
University of Texas Southwestern Medical Center
Co-authored papers 18
Tolga Cagatay
University of Texas Southwestern Medical Center
Co-authored papers 8
Jenny Jiou
University of Texas Southwestern Medical Center
Co-authored papers 6
Chad A Brautigam
UT Southwestern Medical Center
Co-authored papers 6
Jordan M Baumhardt
University of Texas Southwestern Medical Center
Co-authored papers 6
Michael M Soniat
The University of Texas at Austin, USA Center for Systems and Synthetic Biology
Co-authored papers 5
Beatriz M A Fontoura
University of Texas Southwestern Medical Center
Co-authored papers 5
Sheena D'Arcy
The University of Texas at Dallas
Co-authored papers 4
Abhilash Padavannil
University of California davis
Co-authored papers 3
G??nter Blobel
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 3
Michael K Rosen
UT Southwestern Medical Center
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Seung Joong Kim
Korea Advanced Institute of Science and Technology (KAIST)
Co-authored papers 2
Takuya Yoshizawa
College of Life Sciences, Ritsumeikan University
Co-authored papers 2
Tony Pawson
Co-authored papers 2
Thomas J Kipps
University of California San Diego
Co-authored papers 1
Amanda L Christie
Dana-Farber Cancer Institute
Co-authored papers 1
Ronald D Seidel
Albert Einstein College of Medicine
Co-authored papers 1
Rudolf Oldenbourg
Marine Biological Laboratory
Co-authored papers 1
William B Peeples
University of Georgia
Co-authored papers 1
Alex Kentsis
Memorial Sloan-Kettering Cancer Center
Co-authored papers 1
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Peili Chen
University of Chicago
Co-authored papers 1
Zamia Diaz
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Rustam Ali
Howard Hughes Medical Institute, UT Southwestern Medical Center
Co-authored papers 1
Rafael Toro
Medical College of Wisconsin
Co-authored papers 1
Ke Zhang
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Co-authored papers 1
Jeffrey B Bonanno
Albert Einstein College of Medicine
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Release 1.2