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Author Details

Barbara A Weir
Janssen Research and Development LLC
1997
63
46
PMIDPaper TitleJournal TitlePublished Year
36329185The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation.Commun Biol2022
36329185The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation.Commun Biol2022
30664779Small-molecule targeting of brachyury transcription factor addiction in chordoma.Nat Med2019
31068700Next-generation characterization of the Cancer Cell Line Encyclopedia.Nature2019
30664779Small-molecule targeting of brachyury transcription factor addiction in chordoma.Nat Med2019
31461650Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.Cell Rep2019
31461650Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.Cell Rep2019
31068700Next-generation characterization of the Cancer Cell Line Encyclopedia.Nature2019
29202477CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.J Clin Invest2018
29202477CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.J Clin Invest2018
29778836Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.Cell Syst2018
29778836Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.Cell Syst2018
27756750The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.Blood2017
28988802A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.Cell Syst2017
28753430Defining a Cancer Dependency Map.Cell2017
28837809Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.Cell Syst2017
28655788PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.Cancer Res2017
28396387<i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase.Proc Natl Acad Sci U S A2017
29083409Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.Nat Genet2017
27756750The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.Blood2017
28177281Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Elife2017
28396387<i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase.Proc Natl Acad Sci U S A2017
28177281Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Elife2017
29083409Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.Nat Genet2017
28988802A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.Cell Syst2017
28753430Defining a Cancer Dependency Map.Cell2017
28655788PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.Cancer Res2017
28837809Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.Cell Syst2017
26928769High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.Nat Biotechnol2016
26928769High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.Nat Biotechnol2016
27088724Characterizing genomic alterations in cancer by complementary functional associations.Nat Biotechnol2016
26912360MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Science2016
27260156Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.Cancer Discov2016
26582713Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.Mol Cancer Res2016
26582713Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.Mol Cancer Res2016
27260156Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.Cancer Discov2016
26912360MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Science2016
27088724Characterizing genomic alterations in cancer by complementary functional associations.Nat Biotechnol2016
25368431The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer.Mol Cancer Res2015
25368431The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer.Mol Cancer Res2015
26337082Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Oncotarget2015
26337082Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Oncotarget2015
24385586In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.Proc Natl Acad Sci U S A2014
24317510An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.Oncogene2014
24385586In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.Proc Natl Acad Sci U S A2014
24486590Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.Clin Cancer Res2014
24317510An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.Oncogene2014
24486590Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.Clin Cancer Res2014
23269662ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens.Genome Res2013
24218601Synthetic lethality between CCNE1 amplification and loss of BRCA1.Proc Natl Acad Sci U S A2013
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Collaborators

William C Hahn
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 36
Matthew Meyerson
Broad Institute
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Francisca Vazquez
Broad Institute of MIT and Harvard
Co-authored papers 22
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 21
David E Root
Broad Institute of Harvard and MIT
Co-authored papers 21
Rameen Beroukhim
Co-authored papers 20
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 18
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 16
Glenn S Cowley
Broad Institute of Harvard and MIT
Co-authored papers 16
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 14
Gad Getz
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 13
Jill P Mesirov
University of California San Diego
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Craig H Mermel
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University of California San Diego
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Mark A Rubin
University of Bern
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Wendy Winckler
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Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
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Jordi Barretina
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John D Minna
University of Texas Southwestern Medical Center at Dallas
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Thomas J Giordano
University of Michigan ann arbor
Co-authored papers 6
Travis I Zack
Co-authored papers 6
William R Sellers
Co-authored papers 6
Roel G W Verhaak
Yale School of Medicine
Co-authored papers 5
Joseph Rosenbluh
Co-authored papers 5
Thomas LaFramboise
Co-authored papers 5
Gabriela Alexe
Dana-Farber Cancer Institute
Co-authored papers 5
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 5
Mahmoud Ghandi
Co-authored papers 5
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 5
Stuart L Schreiber
Broad Institute
Co-authored papers 4
Release 1.2