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Author Details

Viviane Labrie
Center for Neurodegenerative Science, Van Andel Research Institute
2005
42
26
PMIDPaper TitleJournal TitlePublished Year
37106565Multi-scale systems genomics analysis predicts pathways, cell types, and drug targets involved in normative variation in peri-adolescent human cognition.Cereb Cortex2023
35723531Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms.Mov Disord2022
35431771Methylated Cytochrome P450 and the Solute Carrier Family of Genes Correlate With Perturbations in Bile Acid Metabolism in Parkinson's Disease.Front Neurosci2022
33406628Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson's Disease.Metabolites2021
34557668The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases.Brain Commun2021
34446734Epigenetic inactivation of the autophagy-lysosomal system in appendix in Parkinson's disease.Nat Commun2021
32151270Hemispheric asymmetry in the human brain and in Parkinson's disease is linked to divergent epigenetic patterns in neurons.Genome Biol2020
33273723Evolutionary and structural analysis of SARS-CoV-2 specific evasion of host immunity.Genes Immun2020
32807949Epigenomic analysis of Parkinson's disease neurons identifies Tet2 loss as neuroprotective.Nat Neurosci2020
30342839Triggers, Facilitators, and Aggravators: Redefining Parkinson's Disease Pathogenesis.Trends Neurosci2019
31609697The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?J Parkinsons Dis2019
31496079The crossroads of psychiatric epigenomics.World Psychiatry2019
30842285Parkinson's disease-linked <i>D620N VPS35</i> knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.Proc Natl Acad Sci U S A2019
31113950Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms.Nat Commun2019
31053723Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis.Nat Commun2019
30606238Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease.Genome Biol2019
30516817Harbingers of Mental Disease-Infections Associated With an Increased Risk for Neuropsychiatric Illness in Children.JAMA Psychiatry2019
29440637Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.Nat Commun2018
30381408The vermiform appendix impacts the risk of developing Parkinson's disease.Sci Transl Med2018
27792016Epigenetic Biomarkers for Parkinson's Disease: From Diagnostics to Therapeutics.J Parkinsons Dis2017
28139744Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome.Sci Rep2017
29184902Vertebrate food products as a potential source of prion-like α-synuclein.NPJ Parkinsons Dis2017
29103054Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson's Disease?J Parkinsons Dis2017
28866688Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection.J Innate Immun2017
27159559Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging.Nat Struct Mol Biol2016
27606929Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015.Psychiatr Genet2016
23877302DNA unmethylome profiling by covalent capture of CpG sites.Nat Commun2013
21295046Contributions of the D-serine pathway to schizophrenia.Neuropharmacology2012
229613825-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.Nat Struct Mol Biol2012
22622229Epigenetics of major psychosis: progress, problems and perspectives.Trends Genet2012
22117694Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.J Neurochem2012
21743462A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.Nat Chem Biol2011
19751394Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice.Genes Brain Behav2010
20599655Determination of L-serine-O-phosphate in rat and mouse brain tissue using high-performance liquid chromatography and fluorimetric detection.Anal Biochem2010
20385472Elevated PICK1 mRNA in schizophrenia increased SRR mRNA in suicide.Schizophr Res2010
19695284The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia.Neurosci Biobehav Rev2010
18940194Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors.Pharmacol Biochem Behav2009
19483194Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.Hum Mol Genet2009
17625504D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning.Neuropsychopharmacology2008
19117914Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice.Learn Mem2008
18597079Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.Psychopharmacology (Berl)2008
15759151Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.Psychopharmacology (Berl)2005
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Collaborators

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Co-authored papers 11
Epigenetic Clock Development Foundation
Co-authored papers 8
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Co-authored papers 5
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Co-authored papers 5
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Co-authored papers 4
University of Arkansas for Medical Sciences
Co-authored papers 4
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Co-authored papers 3
National Central University
Co-authored papers 3
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Co-authored papers 3
University of Toronto
Co-authored papers 2
Institute of Neurosciences and Medicine
Co-authored papers 2
Washington University School of Medicine
Co-authored papers 2
University of Toronto, 1 Kings College Circle
Co-authored papers 2
Institute of Medical Sciences, University of Toronto
Co-authored papers 2
Van Andel Institute
Co-authored papers 2
University of Calgary
Co-authored papers 1
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and the Feinberg School of Medicine, Northwestern University
Co-authored papers 1
University of North Carolina School of Medicine
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
University of Toronto
Co-authored papers 1
Campbell Family Mental Health Research Institute
Co-authored papers 1
The Hospital for Sick Children, University of Toronto
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University of Toronto, College St
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Lyon Neuroscience Research Center, University of Lyon, CNRS UMR2, Inserm U1028
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Roche Pharma Research and Early Development
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University of California los angeles
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