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Author Details

Michel Bouvier
Institute for Research in Immunology and Cancer, Universite de Montreal
1981
457
100
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36342455Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination.J Exp Med2023
37543032SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals.Immunity2023
37774973Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.J Biol Chem2023
38036531How carvedilol does not activate β<sub>2</sub>-adrenoceptors.Nat Commun2023
37813859GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.Nat Commun2023
37213429Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine.Open Forum Infect Dis2023
37037304The ubiquitination status of the glucagon receptor determines signal bias.J Biol Chem2023
37464159Enhanced Bystander BRET (ebBRET) Biosensors as Biophysical Tools to Map the Signaling Profile of Neuropsychiatric Drugs Targeting GPCRs.Methods Mol Biol2023
36460099The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens.J Biol Chem2023
34739768Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.Hypertension2022
35846981Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.ACS Pharmacol Transl Sci2022
35482006Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry.J Cell Biol2022
35538063The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites.Nat Commun2022
35764393Immune Responses after a Third Dose of mRNA Vaccine Differ in Virus-Naive versus SARS-CoV-2- Recovered Dialysis Patients.Clin J Am Soc Nephrol2022
35729784Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.J Med Chem2022
35758258New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans.Platelets2022
35779859Michaelis-Menten Quantification of Ligand Signaling Bias Applied to the Promiscuous Vasopressin V2 Receptor.Mol Pharmacol2022
35483354Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant.Immunity2022
36523815Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice.Front Cell Neurosci2022
36369272Computationally designed GPCR quaternary structures bias signaling pathway activation.Nat Commun2022
36173843Structure-based discovery of nonopioid analgesics acting through the α<sub>2A</sub>-adrenergic receptor.Science2022
35862982Performance of 22 Rapid Lateral Flow Tests for SARS-CoV-2 Antigen Detection and Influence of "Variants of Concern": Implications for Clinical Use.Microbiol Spectr2022
36268126Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction.ACS Pharmacol Transl Sci2022
36063022From a Cone Snail Toxin to a Competitive MC4R Antagonist.J Med Chem2022
36384129The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool.Cell Rep2022
34982553Size-Reduced Macrocyclic Analogues of [Pyr<sup>1</sup>]-apelin-13 Showing Negative Gα<sub>12</sub> Bias Still Produce Prolonged Cardiac Effects.J Med Chem2022
35302494Common coupling map advances GPCR-G protein selectivity.Elife2022
35302493Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.Elife2022
35106752Community guidelines for GPCR ligand bias: IUPHAR review 32.Br J Pharmacol2022
34863056Performance of a high-throughput, automated enzyme immunoassay for the detection of SARS-CoV-2 antigen, including in viral "variants of concern": Implications for clinical use.J Clin Virol2022
33350824Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.J Med Chem2021
33571429Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.Cell2021
33649538The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.Oncogene2021
33711555Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.Mol Metab2021
33637518Kinetics of Anti-SARS-CoV-2 IgG Antibodies in Hemodialysis Patients Six Months after Infection.J Am Soc Nephrol2021
33531430Feedback control of the Gpr161-G<sub>αs</sub>-PKA axis contributes to basal Hedgehog repression in zebrafish.Development2021
33860204Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7.ACS Pharmacol Transl Sci2021
33663236In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.Circ Heart Fail2021
33799562Diagnosis and Monitoring of Hepatitis B Virus Infection Using the Cobas<sup>®</sup> HBV Test for Use on the Cobas<sup>®</sup> 4800 System.Microorganisms2021
33524256Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.J Med Chem2021
34614412mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.Immunity2021
34759375GPCR activation mechanisms across classes and macro/microscales.Nat Struct Mol Biol2021
34522296Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome.Chem Sci2021
34466754Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.JACC Basic Transl Sci2021
34583741Ackr3-Venus knock-in mouse lights up brain vasculature.Mol Brain2021
34661078Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.ACS Pharmacol Transl Sci2021
34661070Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation.ACS Pharmacol Transl Sci2021
34508168Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer.Commun Biol2021
33990469BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated G<sub>q</sub> activation at early endosomes.Proc Natl Acad Sci U S A2021
34100068Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national survey.J Antimicrob Chemother2021
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Collaborators

Robert J Lefkowitz
Co-authored papers 19
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 18
Olivier Lichtarge
Baylor College of Medicine
Co-authored papers 8
Justine S Paradis
Moores Cancer Center, University of California San Diego
Co-authored papers 6
Lakshmi A Devi
Co-authored papers 5
Arun K Shukla
Co-authored papers 5
Philippe Froguel
Co-authored papers 4
Amélie Bonnefond
Co-authored papers 4
Anne Marinier
Institute for Research in Immunology and Cancer
Co-authored papers 4
Philippe P Roux
IRIC - University of Montreal
Co-authored papers 4
Mark von Zastrow
University of California san francisco
Co-authored papers 3
Fabien Campagne
Weill Cornell Medical College
Co-authored papers 2
Guillaume Charpentier
Co-authored papers 2
Jo??o P G L M Rodrigues
Stanford University
Co-authored papers 2
Mickaël Canouil
Co-authored papers 2
Stephen W Michnick
Co-authored papers 2
Madan Mohan Babu
St. Jude Children's Research Hospital
Co-authored papers 2
Edward G Lakatta
Co-authored papers 2
Sudarshan Rajagopal
Co-authored papers 2
Jorge Silvio Gutkind
Moores Cancer Center, University of California San Diego
Co-authored papers 2
David E Shaw
Columbia University
Co-authored papers 2
Peter Kolb
Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg
Co-authored papers 2
Georgios Skiniotis
Stanford University School of Medicine
Co-authored papers 2
S??bastien Carreno
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 2
Pierre Corvol
Co-authored papers 1
Jean-Claude Tardif
Montreal Heart Institute, Universite de Montreal
Co-authored papers 1
Ismaa Sadaf Farooqi
Co-authored papers 1
T K Harden
Co-authored papers 1
Marie-Jos??e H??bert
Universite de Montreal
Co-authored papers 1
Nicholas J Wareham
Co-authored papers 1
Release 1.2