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Author Details

Ligong Chen
Tsinghua University
2006
48
30
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34511324Solute carrier transporters: emerging central players in tumour immunotherapy.Trends Cell Biol2022
35469906Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis.J Invest Dermatol2022
35530363Iron Transporters and Ferroptosis in Malignant Brain Tumors.Front Oncol2022
36103816Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state.Cell Rep2022
35152203Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity.Drug Metab Dispos2022
34033814Aspirin inhibits prostaglandins to prevents colon tumor formation via down-regulating Wnt production.Eur J Pharmacol2021
33882315SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility.Cell Rep2021
33618219Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system.Biomaterials2021
33895786An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19.Signal Transduct Target Ther2021
34433664SLC-30A9 is required for Zn<sup>2+</sup> homeostasis, Zn<sup>2+</sup> mobilization, and mitochondrial health.Proc Natl Acad Sci U S A2021
30954949Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.Gut2020
31993307Solute carrier transporters: the metabolic gatekeepers of immune cells.Acta Pharm Sin B2020
32860752Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies.Cancer Cell2020
32373195The solute carrier transporters and the brain: Physiological and pharmacological implications.Asian J Pharm Sci2020
30653498Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.PLoS Biol2019
31686320Regulation of glucose and lipid metabolism in health and disease.Sci China Life Sci2019
32035227DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening.Genomics Proteomics Bioinformatics2019
30239845The SLC transporter in nutrient and metabolic sensing, regulation, and drug development.J Mol Cell Biol2019
31399282Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses.Immunity2019
31534518Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.Theranostics2019
30760873mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis.Cell Death Differ2019
30324491The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2.Protein Cell2019
28871336Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.Arch Toxicol2018
29659562Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.PLoS Biol2018
28924171A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information.Nat Commun2017
28397817Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.Sci Rep2017
28370287A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.Hepatology2017
27128978Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.ACS Chem Biol2016
26467480A deep learning framework for modeling structural features of RNA-binding protein targets.Nucleic Acids Res2016
27260449Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis.Talanta2016
25590948OCT1 in hepatic steatosis and thiamine disposition.Cell Cycle2015
26396683Discovery of Imidazo[1,2-α][1,8]naphthyridine Derivatives as Potential HCV Entry Inhibitor.ACS Med Chem Lett2015
25920679Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.Mol Pharmacol2015
25797421The physiological role of drug transporters.Protein Cell2015
24961373OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.Proc Natl Acad Sci U S A2014
22231567Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.Pharmacogenomics J2013
22456732The role of ATM in response to metformin treatment and activation of AMPK.Nat Genet2012
20567254Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.Pharmacogenomics J2011
21111751GABAA receptor open-state conformation determines non-competitive antagonist binding.Toxicol Appl Pharmacol2011
20371711Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.Mol Cancer Ther2010
20859243Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.Pharmacogenet Genomics2010
20943911Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.J Neurosci2010
20639304Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.J Pharmacol Exp Ther2010
20350125Pharmacogenomics of membrane transporters: past, present and future.Pharmacogenomics2010
19483665Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.Pharmacogenet Genomics2009
19742321Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.PLoS One2009
16537435Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site.Proc Natl Acad Sci U S A2006
17050528Spontaneous mobility of GABAA receptor M2 extracellular half relative to noncompetitive antagonist action.J Biol Chem2006
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Georgia Institute of Technology
Co-authored papers 2
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