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Author Details

Anthony J O'Donoghue
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
2006
107
26
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37748748A Malassezia pseudoprotease dominates the secreted hydrolase landscape and is a potential allergen on skin.Biochimie2024
36710882Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis.Front Mol Biosci2023
37790251A dual-binding magnetic immunoassay to predict spontaneous preterm birth.Front Bioeng Biotechnol2023
37579082Endoproteolysis of Oligopeptide-Based Coacervates for Enzymatic Modeling.ACS Nano2023
37782049Valence-driven colorimetric detection of norovirus protease <i>via</i> peptide-AuNP interactions.Chem Commun (Camb)2023
37578304An approach to zwitterionic peptide design for colorimetric detection of the Southampton norovirus SV3CP protease.Analyst2023
37645851Structural elucidation of recombinant <i>Trichomonas vaginalis</i> 20S proteasome bound to covalent inhibitors.bioRxiv2023
37602819A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of <i>Porphyromonas gingivalis</i> Enzymatic Activity.ACS Nano2023
37354015Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.Protein Sci2023
37459182Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.Biochemistry2023
37058597Empirical Optimization of Peptide Sequence and Nanoparticle Colloidal Stability: The Impact of Surface Ligands and Implications for Colorimetric Sensing.ACS Appl Mater Interfaces2023
37349583Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron.Nat Chem Biol2023
36948708Multiplex substrate profiling by mass spectrometry for proteases.Methods Enzymol2023
37405169Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system.Front Microbiol2023
37435731Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors.Future Med Chem2023
37398257Small Molecule <i>in situ</i> Resin Capture - A Compound First Approach to Natural Product Discovery.bioRxiv2023
37066400Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system.bioRxiv2023
37066163Development of subunit selective substrates for <i>Trichomonas vaginalis</i> proteasome.bioRxiv2023
36963402Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.Cell Chem Biol2023
36409652Peptide Amphiphile Mediated Co-assembly for Nanoplasmonic Sensing.Angew Chem Int Ed Engl2023
36617500Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors.Chemistry2023
36908948Peptide valence-induced breaks in plasmonic coupling.Chem Sci2023
34730959Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.J Med Chem2022
35709506Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.J Med Chem2022
35432913Antiviral cyclic peptides targeting the main protease of SARS-CoV-2.Chem Sci2022
35758417Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain.ACS Chem Neurosci2022
35745663Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L.Pharmaceuticals (Basel)2022
37406055Peptidic Sulfhydryl for Interfacing Nanocrystals and Subsequent Sensing of SARS-CoV-2 Protease.Chem Mater2022
36442106The human pathobiont <i>Malassezia furfur</i> secreted protease Mfsap1 regulates cell dispersal and exacerbates skin inflammation.Proc Natl Acad Sci U S A2022
36539882Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.Parasit Vectors2022
35973073A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease.Anal Chem2022
35941113Native metabolomics identifies the rivulariapeptolide family of protease inhibitors.Nat Commun2022
35910167Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions.ACS Omega2022
35960688Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M<sup>pro</sup> and Papain-like Protease PL<sup>pro</sup> of SARS-CoV-2.J Chem Inf Model2022
35981509Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range.Biochemistry2022
36346642Spacer Matters: All-Peptide-Based Ligand for Promoting Interfacial Proteolysis and Plasmonic Coupling.Nano Lett2022
35878004Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells.ACS Nano2022
36251466Allergen Content and Protease Activity in Milk Feeds from Mothers of Preterm Infants.Breastfeed Med2022
35188371Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against <i>Trypanosoma cruzi</i>.J Med Chem2022
34889013A Dual-Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain-like Proteases of SARS-CoV-2-Infected Cells for Accurate Detection and Rapid Inhibitor Screening.Angew Chem Int Ed Engl2022
35119840Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.Biochemistry2022
34936725A Charge-Switchable Zwitterionic Peptide for Rapid Detection of SARS-CoV-2 Main Protease.Angew Chem Int Ed Engl2022
35018373Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2.bioRxiv2022
34986304Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases.ACS Chem Neurosci2022
34056454Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons.ACS Omega2021
33787221A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.ACS Chem Biol2021
34635581A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.Proc Natl Acad Sci U S A2021
34416110Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.ACS Chem Biol2021
34131661A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.bioRxiv2021
34153188Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing.ACS Chem Neurosci2021
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Collaborators

Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 35
Vivian Hook
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 18
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 17
William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 15
Conor R Caffrey
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 14
Giselle M Knudsen
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 10
Laura Beretta
Co-authored papers 5
Aaron F Carlin
Co-authored papers 5
Florencia La Greca
Department of Pharmaceutical Chemistry , University of California san francisco
Co-authored papers 4
Chien-Te K Tseng
The University of Texas Medical Branch
Co-authored papers 4
Cathal Mahon
Denali Therapeutics Inc.
Co-authored papers 3
Matthew Ravalin
Stanford University
Co-authored papers 3
Mark Larance
The University of Sydney
Co-authored papers 3
Michael B Winter
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Min Zhou
College of Materials Science and Engineering, Hunan University
Co-authored papers 3
Jan Dvor??k
Czech University of Life Sciences
Co-authored papers 3
Joseph L DeRisi
University of California San Francisco
Co-authored papers 2
Qing Liu
Co-authored papers 2
Shauna H Yuan
Co-authored papers 2
Peter Cimermancic
Verily Life Sciences LLC
Co-authored papers 2
Erik B Kistler
Co-authored papers 2
Tsuneya Ikezu
Co-authored papers 2
Markus-Frederik Bohn
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
Marc E Rothenberg
Cincinnati Children's Hospital Medical Center
Co-authored papers 2
David A Maltby
The University of Sydney
Co-authored papers 2
Sabine Ottilie
University of California San Diego
Co-authored papers 2
Victor Nizet
university of california san diego School of Medicine
Co-authored papers 2
Francesco Caiazza
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Pieter C Dorrestein
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Release 1.2