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Author Details
Full Name
Timothy R Lezon
Affiliation
University of Pittsburgh
ORCID
Career Start Year
2004
Papers
23
H Index
13
Expertise
CM4AI Collaborator
Andrej Sali (CM4AI)
PMID
Paper Title
Journal Title
Published Year
34191793
Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells.
PLoS Comput Biol
2021
36303743
Predicting the Effects of Drug Combinations Using Probabilistic Matrix Factorization.
Front Bioinform
2021
31201557
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.
Handb Exp Pharmacol
2019
29736721
A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.
Methods Mol Biol
2018
27951510
Modeling global changes induced by local perturbations to the HIV-1 capsid.
J Mol Graph Model
2017
28231035
Biologically Relevant Heterogeneity: Metrics and Practical Insights.
SLAS Discov
2017
29259176
Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.
Sci Rep
2017
29092944
Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.
Cancer Res
2017
28874589
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Proc Natl Acad Sci U S A
2017
27364358
Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways.
Mol Cell Proteomics
2016
27994939
Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.
J Pathol Inform
2016
24849577
Evol and ProDy for bridging protein sequence evolution and structural dynamics.
Bioinformatics
2014
25036749
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.
PLoS One
2014
22228562
The effects of rigid motions on elastic network model force constants.
Proteins
2012
22455916
Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.
Biophys J
2012
19785456
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.
Chem Rev
2010
20585542
Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology.
PLoS Comput Biol
2010
20192781
Global dynamics of proteins: bridging between structure and function.
Annu Rev Biophys
2010
19730674
Global motions of the nuclear pore complex: insights from elastic network models.
PLoS Comput Biol
2009
16605572
Geometry of proteins: hydrogen bonding, sterics, and marginally compact tubes.
Phys Rev E Stat Nonlin Soft Matter Phys
2006
17138668
Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns.
Proc Natl Acad Sci U S A
2006
16470841
What determines the spectrum of protein native state structures?
Proteins
2006
15103618
Recognition of coarse-grained protein tertiary structure.
Proteins
2004
1 - 23 of 23
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row(s) 1 - 30 of 30
Collaborators
Ivet Bahar
Laufer Center for Physical and Quantitative Biology, Stony Brook University
Co-authored papers
8
Adrian V Lee
Co-authored papers
5
Robert M Friedlander
Co-authored papers
3
Fiona Ginty
GE Global Research Center
Co-authored papers
2
Cemal Erdem
Co-authored papers
2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers
1
Jeffrey L Fine
UPMC Magee-Womens Hospital and University of Pittsburgh School of Medicine
Co-authored papers
1
Jennifer R Grandis
University of California san francisco
Co-authored papers
1
Ajit Jadhav
Co-authored papers
1
Samuel M Poloyac
University of Texas
Co-authored papers
1
Robert Mark Richardson
Massachusetts General Hospital, USA Harvard Medical School
Co-authored papers
1
Anton Simeonov
Co-authored papers
1
1 - 12