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Author Details

Timothy R Lezon
University of Pittsburgh
2004
23
13
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34191793Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells.PLoS Comput Biol2021
36303743Predicting the Effects of Drug Combinations Using Probabilistic Matrix Factorization.Front Bioinform2021
31201557Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.Handb Exp Pharmacol2019
29736721A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.Methods Mol Biol2018
27951510Modeling global changes induced by local perturbations to the HIV-1 capsid.J Mol Graph Model2017
28231035Biologically Relevant Heterogeneity: Metrics and Practical Insights.SLAS Discov2017
29259176Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.Sci Rep2017
29092944Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.Cancer Res2017
28874589Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.Proc Natl Acad Sci U S A2017
27364358Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways.Mol Cell Proteomics2016
27994939Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.J Pathol Inform2016
24849577Evol and ProDy for bridging protein sequence evolution and structural dynamics.Bioinformatics2014
25036749Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.PLoS One2014
22228562The effects of rigid motions on elastic network model force constants.Proteins2012
22455916Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.Biophys J2012
19785456Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.Chem Rev2010
20585542Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology.PLoS Comput Biol2010
20192781Global dynamics of proteins: bridging between structure and function.Annu Rev Biophys2010
19730674Global motions of the nuclear pore complex: insights from elastic network models.PLoS Comput Biol2009
16605572Geometry of proteins: hydrogen bonding, sterics, and marginally compact tubes.Phys Rev E Stat Nonlin Soft Matter Phys2006
17138668Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns.Proc Natl Acad Sci U S A2006
16470841What determines the spectrum of protein native state structures?Proteins2006
15103618Recognition of coarse-grained protein tertiary structure.Proteins2004
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Collaborators

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