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Author Details

Sirano Dhe-Paganon
Dana-Farber Cancer Institute
1989
125
49
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36823301Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.Nat Med2023
37595760Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.J Allergy Clin Immunol2023
37267907Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.Mol Cell2023
36788219Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.NPJ Vaccines2023
36921622Lactate regulates cell cycle by remodelling the anaphase promoting complex.Nature2023
36869134Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.NPJ Vaccines2023
36823351Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.Nat Chem Biol2023
34783582An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.Sci Transl Med2022
35760926Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.Nat Commun2022
35860217Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells.bioRxiv2022
35486727A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.Sci Adv2022
36523401Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.bioRxiv2022
35933439mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.Commun Biol2022
36305736BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.Cancer Discov2022
36355493High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.Pharmaceuticals (Basel)2022
36300789Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.Elife2022
35148840An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.Cell2022
33273722Author Correction: The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma.Nat Struct Mol Biol2021
34413960Exploring Ligand-Directed <i>N</i>-Acyl-<i>N</i>-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.ACS Med Chem Lett2021
34129829Identification and validation of selective deubiquitinase inhibitors.Cell Chem Biol2021
34031655Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity.bioRxiv2021
33972797Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.Nat Chem Biol2021
33284322Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.J Cell Biol2021
32483379Identification of a potent and selective covalent Pin1 inhibitor.Nat Chem Biol2020
33242418Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.Cell2020
32747783The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma.Nat Struct Mol Biol2020
32694660Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation.Nat Metab2020
32359398Identification of a Structural Determinant for Selective Targeting of HDMX.Structure2020
32413285Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.Cell Chem Biol2020
32210275Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.Sci Rep2020
32433464Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.Nat Commun2020
32298120Discovery and Structure-Activity Relationship Study of (<i>Z</i>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.J Med Chem2020
31620231Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.ACS Med Chem Lett2019
31717342Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.Cancers (Basel)2019
31759698Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.Cell2019
32184968Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.ACS Med Chem Lett2019
31175292Structural and functional consequences of the STAT5B<sup>N642H</sup> driver mutation.Nat Commun2019
29276033Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.Structure2018
30093655Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.Nat Commun2018
30065030Islet-Derived eATP Fuels Autoreactive CD8<sup>+</sup> T Cells and Facilitates the Onset of Type 1 Diabetes.Diabetes2018
30010623P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.J Clin Invest2018
29507391Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.Nat Chem Biol2018
28926338MELK is not necessary for the proliferation of basal-like breast cancer cells.Elife2017
28082445p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.Blood2017
28241139Transcription control by the ENL YEATS domain in acute leukaemia.Nature2017
28418626Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.Angew Chem Int Ed Engl2017
28967922Inhibition of USP10 induces degradation of oncogenic FLT3.Nat Chem Biol2017
29056421Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.Cell Chem Biol2017
26947396Data publication with the structural biology data grid supports live analysis.Nat Commun2016
28193034Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes.Anal Chem2016
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Collaborators

Cheryl H Arrowsmith
University of Toronto
Co-authored papers 13
Nathanael S Gray
Harvard Medical School
Co-authored papers 12
James E Bradner
Co-authored papers 8
Matthew B Frieman
Center for Pathogen Research, University of Maryland School of Medicine
Co-authored papers 8
Al Ozonoff
Harvard Medical School
Co-authored papers 5
Dan H Barouch
Co-authored papers 5
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Princess Margaret Cancer Centre
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Irina Bezsonova
University of Connecticut Health Center
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Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Tom W Muir
Princeton University
Co-authored papers 3
Kenneth C Anderson
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Dana-Farber Cancer Institute
Co-authored papers 3
Richard Moriggl
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
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Yi Zheng
Children's Hospital Research Foundation
Co-authored papers 3
Kimberly Stegmaier
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Jason Moffat
University of Toronto
Co-authored papers 2
Steven P Gygi
Harvard Medical School
Co-authored papers 2
Aled M Edwards
University of Toronto
Co-authored papers 2
Andrzej Joachimiak
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 2
Stuart Weston
University of Maryland School of Medicine
Co-authored papers 2
Nir London
The Weizmann Institute of Science
Co-authored papers 2
P??r Nordlund
Karolinska Institutet, BioClinicum J6
Co-authored papers 2
Neil T Umbreit
University of Washington
Co-authored papers 2
Walter J Chazin
and Center for Structural Biology, Vanderbilt University
Co-authored papers 2
Hee-Won Park
Kangwon National University College of Medicine
Co-authored papers 2
Holly Hammond
Center for Pathogen Research, University of Maryland School of Medicine
Co-authored papers 2
Alexei Savchenko
University of Toronto
Co-authored papers 2
Release 1.2