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Author Details

P??r Nordlund
Karolinska Institutet, BioClinicum J6
1989
179
60
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34265272CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity.Cell Chem Biol2022
35922423Correction: Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells.Cell Death Dis2022
35982046Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.Nat Commun2022
36085941CycleDNN - A Novel Deep Neural Network Model for CETSA Feature Prediction cross Cell Lines.Annu Int Conf IEEE Eng Med Biol Soc2022
36085889CETSA Feature Based Clustering for Protein Outlier Discovery by Protein-to-Protein Interaction Prediction.Annu Int Conf IEEE Eng Med Biol Soc2022
34267184Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells.Cell Death Dis2021
33533067Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules.Med Res Rev2021
32341577Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome.Nat Protoc2020
31838273CETSA in integrated proteomics studies of cellular processes.Curr Opin Chem Biol2020
32980441Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020.Pharmacol Ther2020
32335207New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop.Regul Toxicol Pharmacol2020
30602534Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.Sci Transl Med2019
31852908CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance.Sci Rep2019
31267459Hot CoFi Blot: A High-Throughput Colony-Based Screen for Identifying More Thermally Stable Protein Variants.Methods Mol Biol2019
30925293Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA.Redox Biol2019
30939043Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA).Annu Rev Biochem2019
29706543Modulation of Protein-Interaction States through the Cell Cycle.Cell2018
30521565An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions.PLoS One2018
30568786Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.Chem Sci2018
29439025Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.Science2018
27807232Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus.J Virol2017
29259156Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.Nat Commun2017
28634233Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.J Biol Chem2017
26783088The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.FEBS J2016
26566155The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.Annu Rev Pharmacol Toxicol2016
27664121Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.BMC Biol2016
27253209Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design.PLoS Comput Biol2016
26854536Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.Biochemistry2016
27010513CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.Nat Commun2016
26950744A saposin-lipoprotein nanoparticle system for membrane proteins.Nat Methods2016
26758938Understanding transport by the major facilitator superfamily (MFS): structures pave the way.Nat Rev Mol Cell Biol2016
25854864Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.Virology2015
26630264Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.PLoS One2015
26159518Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays.Sci Rep2015
26121039Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.PLoS One2015
26068188VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies.J Gen Virol2015
26085142Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1.J Virol2015
24704254Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.Structure2014
25278616Tracking cancer drugs in living cells by thermal profiling of the proteome.Science2014
25064511Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.Nat Struct Mol Biol2014
25007185Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.PLoS One2014
25003389Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.Biol Chem2014
25101824The cellular thermal shift assay for evaluating drug target interactions in cells.Nat Protoc2014
23526831Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.J Lipid Res2013
24352381Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell.Nat Commun2013
24060988Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.J Struct Biol2013
24205053Nanobody mediated crystallization of an archeal mechanosensitive channel.PLoS One2013
23828940Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.Science2013
23816837Substrate specificity and oligomerization of human GMP synthetase.J Mol Biol2013
23867627Structural insights into substrate recognition in proton-dependent oligopeptide transporters.EMBO Rep2013
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Collaborators

P??l Stenmark
Stockholm University
Co-authored papers 21
Susanne Gr??slund
Karolinska Institutet
Co-authored papers 11
B Martin Hallberg
Karolinska Institutet
Co-authored papers 7
Johan Weigelt
Karolinska Institutet
Co-authored papers 4
Raymond J Owens
University of Oxford
Co-authored papers 4
J??rgen Haas
University of Edinburgh
Co-authored papers 3
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 3
Raymond Hui
University of Toronto
Co-authored papers 3
Christian Cambillau
Aix Marseille University and CNRS
Co-authored papers 3
Aled M Edwards
University of Toronto
Co-authored papers 3
Alexei Savchenko
University of Toronto
Co-authored papers 2
Zbynek Bozdech
Nanyang Technological University
Co-authored papers 2
Youngchang Kim
Argonne National Laboratory
Co-authored papers 2
Adelinda Yee
University of Toronto
Co-authored papers 2
David I Stuart
University of Oxford
Co-authored papers 2
Scott A Lesley
Merck & Co., Inc.
Co-authored papers 2
Shira Albeck
Weizmann Institute of Science
Co-authored papers 2
Andrzej Joachimiak
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 2
Tamar Unger
Weizmann Institute of Science
Co-authored papers 2
Philipp Kaldis
Co-authored papers 2
Sirano Dhe-Paganon
Dana-Farber Cancer Institute
Co-authored papers 2
Joel L Sussman
Weizmann Institute of Science
Co-authored papers 2
Alexander E Gorbalenya
Leiden University Medical Center
Co-authored papers 2
Hee-Won Park
Kangwon National University College of Medicine
Co-authored papers 2
Rong Xiao
School of Public Health, Capital Medical University
Co-authored papers 1
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 1
Kellie Cunningham
Co-authored papers 1
Yang Shen
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Co-authored papers 1
F W Studier
Brookhaven National Laboratory
Co-authored papers 1
Geoffrey S Waldo
Los Alamos National Laboratory
Co-authored papers 1
Release 1.2