Author details

Full Name

Wen Xue

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37291100	Template-jumping prime editing enables large insertion and exon rewriting in vivo.		2023
35932276	Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes.	Hepatology	2023
37709915	Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates.		2023
37156841	Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.		2023
36997680	Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing.		2023
35178738	Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker.	Annals of Neurology	2022
35379962	A split prime editor with untethered reverse transcriptase and circular RNA template.	Nature Biotechnology	2022
35064134	Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.	Nat Commun	2022
34650270	Deletion and replacement of long genomic sequences using prime editing.	Nat Biotechnol	2022
34998953	A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver.	Molecular Therapy	2022
34695545	AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway.	Mol Ther	2022
34588224	Leveraging the Treg-intrinsic CTLA4-PKCÎ· signaling pathway for cancer immunotherapy.	Journal for ImmunoTherapy of Cancer	2021
32452550	YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells.	Hepatology	2021
33837189	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.	Nature Communications	2021
33828315	The NIH Somatic Cell Genome Editing program.	Nature	2021
32975519	miR-19a-3p Functions as an Oncogene by Regulating FBXO32 Expression in Multiple Myeloma.	Balkan Medical Journal	2021
33336367	Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function.	Hepatology	2021
34725353	Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.	Nature Communications	2021
31188495	Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.	Hepatology	2020
31740768	Adenine base editing in an adult mouse model of tyrosinaemia.	Nature Biomedical Engineering	2020
32292501	Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases.	Theranostics	2020
32332735	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.	Nat Commun	2020
30987660	CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling.	Genome Medicine	2019
30581144	A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for InÂ Vivo Genome Editing.	Molecular Cell	2019
30580964	p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.	Cell	2019
30803995	Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.	Cancer Res	2019
31262785	Real-time imaging of integrin Î²4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing.	J Cell Sci	2019
30664678	CRISPR-Cas: a tool for cancer research and therapeutics.	Nature Reviews Clinical Oncology	2019
29597895	In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency.	Hum Gene Ther	2018
30400804	Understanding and repurposing CRISPR-mediated alternative splicing.		2018
30148885	The temporal landscape of recursive splicing during Pol II transcription elongation in human cells.	PLoS Genet	2018
30102296	Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.	Nature Biotechnology	2018
30231914	All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo.		2018
29443117	CRISPR-Cas-related technologies in basic and translational liver research.	Nature Reviews Gastroenterology and Hepatology	2018
29377001	Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.	Nature Chemical Biology	2018
27956228	Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.	Gastroenterology	2017
28489818	A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.	Nature	2017
28615073	CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.	Genome Biol	2017
28320962	Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis.	Proc Natl Acad Sci U S A	2017
28697339	Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.	Cancer Cell	2017
29131148	Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.	Nature Biotechnology	2017
26658687	RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.	Journal of Hepatology	2016
26887506	A Modular Assembly Platform for Rapid Generation of DNA Constructs.	Sci Rep	2016
26829318	Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.	Nat Biotechnol	2016
27259155	p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer.	Cell	2016
27485003	Genomic Amplifications Cause False Positives in CRISPR Screens.	Cancer Discovery	2016
26086867	Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.	Hum Gene Ther	2015
30191010	The search for precision models clinically relevant to human liver cancer.		2015
25789998	Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.	Nano Lett	2015
25738607	Reciprocal interaction of Wnt and RXR-Î± pathways in hepatocyte development and hepatocellular carcinoma.	PLoS One	2015