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Author Details

Alan H Fairlamb
University of Dundee
1974
262
69
PMIDPaper TitleJournal TitlePublished Year
37402863Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.Nature2023
37600222The critical role of mode of action studies in kinetoplastid drug discovery.Front Drug Discov (Lausanne)2023
34531949Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.ACS Med Chem Lett2021
33691122Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.Cell Chem Biol2021
34471283Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases.Nat Rev Drug Discov2021
34410327Surmounting structural barriers to tackle endemic infectious diseases.J Exp Med2021
32292551New 8-Nitroquinolinone Derivative Displaying Submicromolar <i>in Vitro</i> Activities against Both <i>Trypanosoma brucei</i> and <i>cruzi</i>.ACS Med Chem Lett2020
31967783The Q<sub>i</sub> Site of Cytochrome <i>b</i> is a Promiscuous Drug Target in <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>.ACS Infect Dis2020
32795774Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.Eur J Med Chem2020
326524098-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.Eur J Med Chem2020
32275825Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase.ACS Infect Dis2020
29701144Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis.Curr Med Chem2019
31840685Fexinidazole for the treatment of human African trypanosomiasis.Drugs Today (Barc)2019
31188540Substituted Aminoacetamides as Novel Leads for Malaria Treatment.ChemMedChem2019
30894487Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.Proc Natl Acad Sci U S A2019
30962368Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.Proc Natl Acad Sci U S A2019
30380837Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.ACS Infect Dis2019
29705579Melarsoprol Resistance in African Trypanosomiasis.Trends Parasitol2018
29885575Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.Eur J Med Chem2018
30046105Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.Nature2018
30045874A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.Biochem J2018
30206344Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Nat Rev Microbiol2018
300923668-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.Eur J Med Chem2018
30221468Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions.ChemMedChem2018
29844044Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.Antimicrob Agents Chemother2018
30655943Nongenotoxic 3-Nitroimidazo[1,2-<i>a</i>]pyridines Are NTR1 Substrates That Display Potent <i>in Vitro</i> Antileishmanial Activity.ACS Med Chem Lett2018
30264983Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.ACS Infect Dis2018
29777624Characterisation of a putative glutamate 5-kinase from Leishmania donovani.FEBS J2018
27798837Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.ACS Infect Dis2017
28239154Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Nat Rev Microbiol2017
28967262Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.ACS Infect Dis2017
29115999Screening a protein kinase inhibitor library against Plasmodium falciparum.Malar J2017
28579611Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Nat Rev Microbiol2017
26682963Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.J Antimicrob Chemother2016
26581221Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.J Antimicrob Chemother2016
27703008The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.J Biol Chem2016
27812217Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.PLoS Pathog2016
27631715Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.J Med Chem2016
27175479Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase.PLoS Negl Trop Dis2016
27572976Drug resistance in eukaryotic microorganisms.Nat Microbiol2016
27492267The N-myristoylome of Trypanosoma cruzi.Sci Rep2016
27314305Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.J Med Chem2016
27215734The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.Elife2016
27281209Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.Nature2016
27020099Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases.Nat Rev Drug Discov2016
25367138Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.Mol Microbiol2015
26312902Arsenic, antimony, and Leishmania: has arsenic contamination of drinking water in India led to treatment- resistant kala-azar?Lancet2015
26684831Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.PLoS Negl Trop Dis2015
26085270A novel multiple-stage antimalarial agent that inhibits protein synthesis.Nature2015
25678015Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.Bioorg Med Chem2015
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Collaborators

Wellcome Sanger Institute
Co-authored papers 12
University of California San Diego
Co-authored papers 7
University of Dundee
Co-authored papers 4
International Livestock Research Institute (ILRI)
Co-authored papers 2
Center for Computational Biology, Johns Hopkins University
Co-authored papers 2
Wellcome Trust Sanger Institute
Co-authored papers 2
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 2
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Co-authored papers 2
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
Earlham Institute
Co-authored papers 2
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
The Institute for Genomic Research, 9712 Medical Center Drive
Co-authored papers 2
University of Dundee
Co-authored papers 2
University of Guelph
Co-authored papers 2
Institute of Integrative Biology, University of Liverpool
Co-authored papers 2
Center for Emerging and Re-emerging Infectious Diseases, University of Washington
Co-authored papers 2
Global Health Pharma Unit
Co-authored papers 2
Macquarie University
Co-authored papers 1
University of Washington School of Medicine
Co-authored papers 1
School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo
Co-authored papers 1
Wellcome Trust Sanger Institute
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
University of Cambridge
Co-authored papers 1
Julius-Maximilians-Universitat Wurzburg
Co-authored papers 1
University of Oxford
Co-authored papers 1
The Rockefeller University
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Center for Molecular Parasitology, Drexel University College of Medicine
Co-authored papers 1
Research and Clinical Development
Co-authored papers 1
Institute for Genome Research
Co-authored papers 1