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Author Details

Robert E Lewis
University of Nebraska Medical Center
1980
154
36
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37972068SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status.Proc Natl Acad Sci U S A2023
36230802PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2.Cancers (Basel)2022
35697074A novel antiproliferative PKCα-Ras-ERK signaling axis in intestinal epithelial cells.J Biol Chem2022
36342465Contrasting effects of <i>Ksr2</i>, an obesity gene, on trabecular bone volume and bone marrow adiposity.Elife2022
33970103KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition.Elife2021
33120942A Gene Expression High-Throughput Screen (GE-HTS) for Coordinated Detection of Functionally Similar Effectors in Cancer.Cancers (Basel)2020
31964871High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen.Sci Data2020
30629587ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells.PLoS One2019
30198569The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway.Br J Haematol2019
31378711A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery.Cell Chem Biol2019
30770249O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.Immunity2019
29491475A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.Sci Rep2018
29925347WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage.BMC Cancer2018
30530853Correction: KSR1 is required for cell cycle reinitiation following DNA damage.J Biol Chem2018
29026529Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras.F1000Res2017
28333549KSR as a therapeutic target for Ras-dependent cancers.Expert Opin Ther Targets2017
27273865KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors.Mol Cell Biol2016
28180061Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.Mol Metab2016
27561547Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2).Sci Rep2016
26079660Hormone receptor-independent CXCL10 production is associated with the regulation of cellular factors linked to breast cancer progression and metastasis.Exp Mol Pathol2015
26351140AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.Mol Cell Biol2015
26365306Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability.Sci Rep2015
24333352Nicole Suciu-Foca, PhD, Worthy Heir of Mendel and Medawar.Hum Immunol2014
25002533Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation.Mol Cell Biol2014
24997067Obesity-dependent dysregulation of glucose homeostasis in kinase suppressor of ras 2-/- mice.Physiol Rep2014
24836676Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells.Exp Mol Pathol2014
24731923Comparative analysis of innate immune system function in metastatic breast, colorectal, and prostate cancer patients with circulating tumor cells.Exp Mol Pathol2014
24918056Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm.FEBS Open Bio2014
22710034The fate of renal allografts hinges on responses of the microvascular endothelium.Exp Mol Pathol2013
24129700Using functional signature ontology (FUSION) to identify mechanisms of action for natural products.Sci Signal2013
23831428Circulating tumor cells (CTCs) from metastatic breast cancer patients linked to decreased immune function and response to treatment.Exp Mol Pathol2013
24001767Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.Mol Cell Biol2013
23592054Julius M. Cruse: his rendezvous with immunology.Immunol Res2013
22392055Immunologic research: Publishing knowledge of the future today!: the first three decades.Immunol Res2012
23036473Julius M. Cruse, Mentor and Mensch.Exp Mol Pathol2012
23142111Foreword: special issue cruse festschrift.Exp Mol Pathol2012
22801368Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK.Mol Cell Biol2012
22609240Decreased humoral antibody episodes of acute renal allograft rejection in recipients expressing the HLA-DQβ1*0202 allele.Exp Mol Pathol2012
21435442KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.Am J Pathol2011
22206009Regulation of glucose homeostasis by KSR1 and MARK2.PLoS One2011
21878642KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1.J Biol Chem2011
21518958Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth.Mol Cell Biol2011
21497601HLA DRB1*1503 allelic haplotype predominance and associated immunodysregulation in systemic lupus erythematosus.Exp Mol Pathol2011
19769961Toll-like receptor and chemokine receptor expression in HIV-infected T lymphocyte subsets.Exp Mol Pathol2010
20599935DRβ1*1501, DQβ1*0602 donor allelic haplotype and humoral antibody episodes of acute renal allograft rejection.Exp Mol Pathol2010
19139278The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.Mol Cell Biol2009
19883615KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.Cell Metab2009
19631641Decreased TLR4 gene expression in leukemic leukocyte populations.Exp Mol Pathol2009
19147494KSR1 is required for cell cycle reinitiation following DNA damage.J Biol Chem2009
19114553Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.Mol Cell Biol2009
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Collaborators

University of Nebraska Medical Center
Co-authored papers 17
University of Georgia
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Seoul National University
Co-authored papers 5
University of California
Co-authored papers 4
UT Southwestern Medical Center
Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 1
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Co-authored papers 1
University of California San Francisco
Co-authored papers 1
The University of Texas Southwestern Medical Center
Co-authored papers 1
University of Nebraska Medical Center
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of Nebraska School of Medicine
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
Co-authored papers 1
Universidad Autonoma de San Luis Potosi
Co-authored papers 1
Virginia Commonwealth University
Co-authored papers 1
Quantitative Biomedical Research Center
Co-authored papers 1
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University of California San Diego
Co-authored papers 1
Beijing Friendship Hospital, Capital Medical University
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