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Author Details

Shimon Sakaguchi
Institute for Frontier Medical Sciences, Kyoto University
1981
352
117
PMIDPaper TitleJournal TitlePublished Year
36454183Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.J Exp Med2023
37667082Author Correction: Regulatory T cells in autoimmune kidney diseases and transplantation.Nat Rev Nephrol2023
37559728Identification of the novel FOXP3-dependent T<sub>reg</sub> cell transcription factor MEOX1 by high-dimensional analysis of human CD4<sup>+</sup> T cells.Front Immunol2023
37494986Nrf2 activation improves experimental rheumatoid arthritis.Free Radic Biol Med2023
37440410A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.Cell Rep2023
37400628Regulatory T cells in autoimmune kidney diseases and transplantation.Nat Rev Nephrol2023
37397971Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective.Immunother Adv2023
36917950Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy.Cancer Cell2023
36669118A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.Proc Natl Acad Sci U S A2023
36529525Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer.Cancer Sci2023
34716967Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia.Cancer Sci2022
35675777PGE<sub>2</sub>-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.Cell Rep2022
35438346The ratio of CD8â¿¿+â¿¿lymphocytes to tumor-infiltrating suppressive FOXP3â¿¿+â¿¿effector regulatory T cells is associated with treatment response in invasive breast cancer.Discov Oncol2022
35869073Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma.Nat Commun2022
36121747Protocol to evaluate cell lineage stability of mouse natural and induced regulatory T cells using bisulfite sequencing.STAR Protoc2022
34910106B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice.J Exp Med2022
35140181CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.Proc Natl Acad Sci U S A2022
34725966Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity.Arthritis Rheumatol2022
34802121Using Mass Cytometry to Address Tfh and Tfr Heterogeneity.Methods Mol Biol2022
33017003VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data.Bioinformatics2021
33709737Quasifree Neutron Knockout Reaction Reveals a Small s-Orbital Component in the Borromean Nucleus ^{17}B.Phys Rev Lett2021
33483505CTLA-4 expression by B-1a B cells is essential for immune tolerance.Nat Commun2021
33930308Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.Immunity2021
34548542Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.Sci Rep2021
34748274Isolation and Characterization of Both Human and Mouse Tfh/Tfr Cells.Curr Protoc2021
34301886Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells.Proc Natl Acad Sci U S A2021
34037676Taking regulatory T cells into medicine.J Exp Med2021
34006522Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.Cancer Immunol Res2021
34083792Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.Nat Biotechnol2021
34136184Brazilian green propolis promotes TNFR2 expression on regulatory T cells.Food Sci Nutr2021
33414270Reply to Slominski et al.: UVB irradiation induces proenkephalin<sup>+</sup> regulatory T cells with a wound-healing function.Proc Natl Acad Sci U S A2021
32367041Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases.Cell Res2020
31704808Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.J Exp Med2020
32017635Regulatory T Cells and Human Disease.Annu Rev Immunol2020
31950169Clinical importance of the expression of CD4+CD8+ T cells in renal cell carcinoma.Int Immunol2020
31944330Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.Immunol Rev2020
33375291Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy.Cancers (Basel)2020
33055428PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.JCI Insight2020
33416401Surface Localization of the Dineutron in ^{11}Li.Phys Rev Lett2020
32827951New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression.Curr Opin Immunol2020
32769209Proenkephalin<sup>+</sup> regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.Proc Natl Acad Sci U S A2020
32339846Dynamics of effector and naïve Regulatory T cells throughout pregnancy.J Reprod Immunol2020
32362325Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases.Immunity2020
32277125Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma.Sci Rep2020
32414925Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.Proc Natl Acad Sci U S A2020
32564426Control of foreign Ag-specific Ab responses by Treg and Tfr.Immunol Rev2020
30280968Preparation of Immunotolerant Space Under the Skin and Transplantation of Islets in the Space.Tissue Eng Part A2019
31758535Control of Regulatory T Cells by Co-signal Molecules.Adv Exp Med Biol2019
31681278Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells.Front Immunol2019
31653719Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T<sub>reg</sub> cells by inhibition of CDK8/19.Sci Immunol2019
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Collaborators

Naganari Ohkura
Graduate School of Medicine, Osaka University
Co-authored papers 51
Masahide Hamaguchi
Kyoto Prefectural University of Medicine
Co-authored papers 11
Hiromasa Morikawa
WPI Immunology Frontier Research Center, Osaka University
Co-authored papers 11
Lloyd J Old
Ludwig Institute for Cancer Research
Co-authored papers 5
Masayuki Yamamoto
Tohoku University Graduate School of Medicine, Tohoku University
Co-authored papers 4
Toshio Kitamura
The University of Tokyo.
Co-authored papers 3
Hiroshi Kawamoto
Institute for Life and Medical Sciences, Kyoto University
Co-authored papers 3
Yoshihide Hayashizaki
Center for Integrative Medical Sciences
Co-authored papers 3
Hozumi Motohashi
Institute of Development, Tohoku University
Co-authored papers 3
Masayoshi Itoh
RIKEN Center for Integrative Medical Sciences
Co-authored papers 3
Sacha Gnjatic
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Matthias Edinger
Regensburg University Hospital
Co-authored papers 3
Timo Lassmann
Telethon Kids Institute, University of Western Australia
Co-authored papers 3
Piero Carninci
RIKEN Center for Integrative Medical Sciences
Co-authored papers 3
Alistair R R Forrest
RIKEN Center for Integrative Medical Sciences
Co-authored papers 3
Hideya Kawaji
RIKEN Center for Integrative Medical Sciences
Co-authored papers 3
Hiroshi Ohno
RIKEN Center for Integrative Medical Sciences
Co-authored papers 3
Sayaka Nagao-Sato
Ochanomizu University
Co-authored papers 3
Tony J Kenna
Queensland University of Technology
Co-authored papers 2
Albert S B Edge
Harvard Medical School
Co-authored papers 2
Christophe Simon
RIKEN Yokohama Institute
Co-authored papers 2
Peter Heutink
German Center for Neurodegenerative Diseases (DZNE).
Co-authored papers 2
Ernst J Wolvetang
Australian Institute for Bioengineering and Nanotechnology, University of Queensland
Co-authored papers 2
Suzana Savvi
South African Medical Research Council (SAMRC), University of Cape Town
Co-authored papers 2
Soichi Ogishima
Tohoku University Graduate School of Medicine
Co-authored papers 2
Christine L Mummery
Leiden University Medical Center
Co-authored papers 2
Weonju Lee
Kyungpook National University, Kyungpook National University Hospital
Co-authored papers 2
Yohei Yonekura
RIKEN Center for Developmental Biology
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Release 1.2