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Author Details

Sandrine Humbert
Grenoble Institut Neurosciences, INSERM, Universite Grenoble Alpes
1992
90
42
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36409218Huntingtin regulates calcium fluxes in skeletal muscle.J Gen Physiol2023
37442131Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration.Neuron2023
37094259[Treating early transient neuronal defects in a mouse model of Huntington's disease delays the signs of the disease in adulthood].Med Sci (Paris)2023
34793694Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1.Neuron2022
35597611When does Huntington disease begin?Rev Neurol (Paris)2022
36847466Huntington's disease and brain development.C R Biol2022
36044862Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton.Cell Rep2022
36137051Treating early postnatal circuit defect delays Huntington's disease onset and pathology in mice.Science2022
35943803A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function.JCI Insight2022
35147158Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington's disease reveals early gray and white matter alterations.Hum Mol Genet2022
34985962Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus.Sci Adv2022
33983118Propensity for somatic expansion increases over the course of life in Huntington disease.Elife2021
33789888Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice.Sci Adv2021
33591252[Huntington disease: Neurodegeneration rooted in brain development?]Med Sci (Paris)2021
33748784Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment.STAR Protoc2021
32452382Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin.Elife2020
32675289Huntington's disease alters human neurodevelopment.Science2020
32640230Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.Cell Rep2020
29534157The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.Brain2018
29889077Cancer: From Wild-Type to Mutant Huntingtin.J Huntingtons Dis2018
28017473Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.Neuron2017
28202696Low cancer prevalence in polyglutamine expansion diseases.Neurology2017
29146868Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.Science2017
26863614Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells.PLoS One2016
27615166[Beyond the brain: huntingtin in breast cancers].Med Sci (Paris)2016
27388901Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.PLoS One2016
27525439Serine 421 regulates mutant huntingtin toxicity and clearance in mice.J Clin Invest2016
26938440The Biology of Huntingtin.Neuron2016
26980106CAG repeat size in Huntingtin alleles is associated with cancer prognosis.Eur J Hum Genet2016
24841383Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.Mol Neurobiol2015
26293574Unraveling the Role of Huntingtin in Breast Cancer Metastasis.J Natl Cancer Inst2015
26165689Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.EMBO J2015
25942483Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC.PLoS Biol2015
25475049A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease.Mov Disord2015
24347322IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.Mol Neurobiol2014
25385587Potential function for the Huntingtin protein as a scaffold for selective autophagy.Proc Natl Acad Sci U S A2014
25057205Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex.J Neurosci2014
24749073Huntingtin regulates mammary stem cell division and differentiation.Stem Cell Reports2014
24795586Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms.Front Behav Neurosci2014
24960692Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.Dev Cell2014
23300147The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.EMBO Mol Med2013
25062728Huntingtin: here, there, everywhere!J Huntingtons Dis2013
23830927The impact of single-nucleotide polymorphisms (SNPs) in OGG1 and XPC on the age at onset of Huntington disease.Mutat Res2013
24019939Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse.PLoS One2013
23678106Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.J Neurosci2013
22123819Early alterations of brain cellular energy homeostasis in Huntington disease models.J Biol Chem2012
21439401Mitotic spindle: focus on the function of huntingtin.Int J Biochem Cell Biol2011
21382317[Huntingtin, mitosis and cell fate].Med Sci (Paris)2011
20036197Elongator - an emerging role in neurological disorders.Trends Mol Med2010
21102640Is Huntington disease a developmental disorder?EMBO Rep2010
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Collaborators

Alexandra Durr
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 9
Monia Barnat
University Grenoble Alpes, Inserm, Grenoble Institute Neurosciences
Co-authored papers 7
Hua Yu
Guangzhou University
Co-authored papers 4
Fabrice P Cordelières
Co-authored papers 4
Li-Huei Tsai
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 4
Alexis Brice
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 3
Steven Finkbeiner
J. David Gladstone Institutes
Co-authored papers 3
Sophie Dodier
Institut Curie, France INSERM U1, France CNRS UMR 3347
Co-authored papers 2
Marcy E MacDonald
Co-authored papers 2
Sylvie Forlani
ICM DNA and Cell Bank CNRS UMR7225, INSERM U1127, Sorbonne University
Co-authored papers 1
Fran??ois Guillemot
the Francis Crick Institute
Co-authored papers 1
Pierre Lepage
Co-authored papers 1
Aurore Mensah
Rigshospitalet-Glostrup Valdemar Hansens Vej 1-23
Co-authored papers 1
Marc Remke
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 1
Michael R Hayden
Co-authored papers 1
Audrey L Mercier
Institut Curie, CNRS UMR 3306, INSERM U1005, Centre Universitaire
Co-authored papers 1
Antoine Forget (CM4AI)
University of California San Francisco
Co-authored papers 1
En Li
Co-authored papers 1
Mickael Garcia
Institut Curie
Co-authored papers 1
David E Housman
Co-authored papers 1
Juan C Troncoso
Co-authored papers 1
Leslie M Thompson
Co-authored papers 1
Eliezer Masliah
National Institute On Aging
Co-authored papers 1
Hamasseh Shirvani
Institut Roche
Co-authored papers 1
Olivier Ayrault
Institut Curie, PSL Research University, CNRS UMR, INSERM
Co-authored papers 1
Juan Botas
Baylor College of Medicine
Co-authored papers 1
Elisabetta Marangoni
Co-authored papers 1
Anna Lasorella
Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
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Sophie Leboucher
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Release 1.2