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Author Details

Ursula Schulze-Gahmen
Gladstone Institute of Virology, Gladstone Institutes San Francisco CA USA .
1985
45
27
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37198487RNA conformational propensities determine cellular activity.Nature2023
37025664A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.RSC Adv2023
37312993Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.RSC Adv2023
37296211Author Correction: RNA conformational propensities determine cellular activity.Nature2023
36075902Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.Nat Commun2022
34031651CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.Res Sq2021
33853786Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.Sci Adv2021
33758899Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation.medRxiv2021
33991487Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant.Cell2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
30514815Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex.Proc Natl Acad Sci U S A2018
28322550Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs.Anal Chem2017
28134250Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.Nat Commun2017
27731797Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.Elife2016
26007649Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.Nucleic Acids Res2015
24367103AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.Proc Natl Acad Sci U S A2014
24843025AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.Elife2014
23251033HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.Proc Natl Acad Sci U S A2013
23471103The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.Elife2013
16789739Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.J Med Chem2006
15689157Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.J Med Chem2005
16204885Structure of the hypothetical Mycoplasma protein MPN555 suggests a chaperone function.Acta Crystallogr D Biol Crystallogr2005
16211501Structural genomics of minimal organisms and protein fold space.J Struct Funct Genomics2005
15123424Structural studies of the Nudix hydrolase DR1025 from Deinococcus radiodurans and its ligand complexes.J Mol Biol2004
12595731Crystallization of a member of the recFOR DNA repair pathway, RecO, with and without bound oligonucleotide.Acta Crystallogr D Biol Crystallogr2003
14649297Structure-based functional inference in structural genomics.J Struct Funct Genomics2003
12657797Purification, crystallization and preliminary X-ray analysis of two nudix hydrolases from Deinococcus radiodurans.Acta Crystallogr D Biol Crystallogr2003
12577257Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein.Proteins2003
11828325Structural basis for CDK6 activation by a virus-encoded cyclin.Nat Struct Biol2002
11526321Crystallization of a complex between human CDK6 and a virus-encoded cyclin is critically dependent on the addition of small charged organic molecules.Acta Crystallogr D Biol Crystallogr2001
10368294Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.Structure1999
8610110Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.Proc Natl Acad Sci U S A1996
9552391Structural basis for chemical inhibition of CDK2.Prog Cell Cycle Res1996
8917641High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.J Med Chem1996
7479711Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine.Proteins1995
7520084Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen.J Mol Biol1994
8263915Detailed analysis of the free and bound conformations of an antibody. X-ray structures of Fab 17/9 and three different Fab-peptide complexes.J Mol Biol1993
1522592Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.J Mol Biol1992
1546293Structural evidence for induced fit as a mechanism for antibody-antigen recognition.Science1992
1959445Structural aspects of antibodies and antibody-antigen complexes.Ciba Found Symp1991
2485209Monoclonal antibodies against an identical short peptide sequence shared by two unrelated proteins.Pept Res1989
3182835Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide Fab and its complex with a synthetic peptide from influenza virus hemagglutinin.J Biol Chem1988
2428615Immunogenicity of loop-structured short synthetic peptides mimicking the antigenic site A of influenza virus hemagglutinin.Eur J Biochem1986
2411545Towards assignment of secondary structures by anti-peptide antibodies. Specificity of the immune response to a beta-turn.EMBO J1985
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Collaborators

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The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
Gladstone Institutes
Co-authored papers 4
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Co-authored papers 3
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