Author details

Full Name

Snorri S Thorgeirsson

Affiliation

ORCID

Career Start Year

1969

Papers

516

H Index

101

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34817932	Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells.	Hepatol Commun	2022
35572980	What Makes Cirrhosis Irreversible?-Consideration on Structural Changes.	Frontiers in Medicine	2022
35132819	miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver.	Hepatol Commun	2022
34375307	Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.	JCI insight	2021
31108004	c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-Î²-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch.	Stem Cells	2019
30485423	Application of patient-derived liver cancer cells for phenotypic characterization and therapeutic target identification.	Int J Cancer	2019
30862714	Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM<sup>+</sup> Hepatocellular Carcinoma.	Cancer Res	2019
30082483	Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer.	Molecular Cancer Research	2018
28608943	Transcriptomic and histopathological analysis of cholangiolocellular differentiation trait in intrahepatic cholangiocarcinoma.	Liver International	2018
30064387	Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells.	BMC Cancer	2018
27872089	Transcriptional Induction of Periostin by a Sulfatase 2-TGFÎ²1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma.	Cancer Research	2017
28648284	Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.	Cancer Cell	2017
28467999	Stemness in Liver Cancer.	Digestive Diseases	2017
28415775	Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas.	Oncotarget	2017
27956228	Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.	Gastroenterology	2017
27611696	Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress.	PLoS ONE	2016
27394961	Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.	Toxicology	2016
26844528	Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.	Hepatology	2016
27326258	Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin.	J Cancer	2016
26999257	DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.	Hepatology	2016
26600290	Stemness and reprogramming in liver cancer.	Hepatology	2016
26668215	A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.	Mol Pharmacol	2016
27806330	Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis.	Oncotarget	2016
25236463	Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.	Bioinformatics	2015
25597408	Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma.	Oncogene	2015
25647164	Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells.	Thyroid	2015
25477280	The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.	FASEB Journal	2015
25953724	Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma.	Hepatology	2015
25937435	Curcumin effectively inhibits oncogenic NF-ÎºB signaling and restrains stemness features in liver cancer.	Journal of Hepatology	2015
26305952	Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.	Proc Natl Acad Sci U S A	2015
26173068	Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression.	Hepatology	2015
26493646	Functional and genetic deconstruction of the cellular origin in liver cancer.	Nature Reviews Cancer	2015
26154152	Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.	Hepatology	2015
24735920	Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care.	Cancer Cell	2014
30190968	The biological and clinical challenge of liver cancer heterogeneity.	Hepat Oncol	2014
25536056	Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.	PLoS Med	2014
25392503	The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.	J Neurosci	2014
25295540	Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model.	Journal of Clinical Investigation	2014
24449497	Epigenetic reprogramming modulates malignant properties of human liver cancer.	Hepatology	2014
24308993	Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends.	Journal of Hepatology	2014
24016071	CellMinerHCC: a microarray-based expression database for hepatocellular carcinoma cell lines.	Liver Int	2014
24772266	A perspective on molecular therapy in cholangiocarcinoma: present status and future directions.	Hepatic Oncology	2014
25189530	MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.	Cancer Research	2014
24512821	Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits.	Journal of Hepatology	2014
24648346	CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells.	Cancer Res	2014
24958469	Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2.	Cancer Research	2014
24735926	SnapShot: Hepatocellular carcinoma.	Cancer Cell	2014
23411027	Label-retaining liver cancer cells are relatively resistant to sorafenib.	Gut	2013
22824796	Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.	Oncogene	2013
23913923	Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling.	Genes and Development	2013