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Author Details

James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
1970
380
82
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36818551Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of <i>Leishmania</i> infection.Front Trop Dis2023
37719668Molecular identification of phlebotomine sand flies and the harbored <i>Leishmania</i> spp. in Sokoto State, Nigeria.Front Cell Infect Microbiol2023
37851179Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines.Parasitol Res2023
37435731Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors.Future Med Chem2023
34730959Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.J Med Chem2022
35709506Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.J Med Chem2022
35745663Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L.Pharmaceuticals (Basel)2022
36365024Identification of Novel Genes and Proteoforms in <i>Angiostrongylus costaricensis</i> through a Proteogenomic Approach.Pathogens2022
35960688Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M<sup>pro</sup> and Papain-like Protease PL<sup>pro</sup> of SARS-CoV-2.J Chem Inf Model2022
35188371Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against <i>Trypanosoma cruzi</i>.J Med Chem2022
35284725Identification of Leucinostatins from <i>Ophiocordyceps</i> sp. as Antiparasitic Agents against <i>Trypanosoma cruzi</i>.ACS Omega2022
35018373Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2.bioRxiv2022
33466870An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease.Pathogens2021
33787221A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.ACS Chem Biol2021
33503071First report on prevalence of SARS-CoV-2 infection among health-care workers in Nicaragua.PLoS One2021
33929276<i>Acanthamoeba</i> Keratitis: an update on amebicidal and cysticidal drug screening methodologies and potential treatment with azole drugs.Expert Rev Anti Infect Ther2021
34606502Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease.PLoS Negl Trop Dis2021
34461718Structure-Based Optimization of Quinazolines as Cruzain and <i>Tbr</i>CATL Inhibitors.J Med Chem2021
33992862Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases.Bioorg Med Chem2021
34068119Dysregulation of Glycerophosphocholines in the Cutaneous Lesion Caused by <i>Leishmania major</i> in Experimental Murine Models.Pathogens2021
32125159Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.J Med Chem2020
31876154Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.ACS Infect Dis2020
31876143Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.ACS Infect Dis2020
32094126The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii.Antimicrob Agents Chemother2020
33140046A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.bioRxiv2020
33398273Potent <i>in vitro</i> anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L.bioRxiv2020
32970692Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.PLoS Negl Trop Dis2020
32184953Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.ACS Med Chem Lett2020
32433643Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways.PLoS Negl Trop Dis2020
32322173Herbal melanin inhibits colorectal cancer cell proliferation by altering redox balance, inducing apoptosis, and modulating MAPK signaling.Cancer Cell Int2020
32224991High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for <i>Trypanosoma cruzi</i>.Microorganisms2020
31583882Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of <i>Naegleria fowleri</i> Sterol ο8-ο7-Isomerase and Phenotypic Assays.ACS Infect Dis2019
29559968<i>In Vitro</i> Efficacy of Ebselen and BAY 11-7082 Against <i>Naegleria fowleri</i>.Front Microbiol2018
30138311The diverse roles of cysteine proteases in parasites and their suitability as drug targets.PLoS Negl Trop Dis2018
30138309Update on drug development targeting parasite cysteine proteases.PLoS Negl Trop Dis2018
30166569Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data.Sci Rep2018
30630278Impact of Single Dose Praziquantel Treatment on Schistosoma haematobium Infection among School Children in an Endemic Nigerian Community.Korean J Parasitol2018
30379807Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms.PLoS Negl Trop Dis2018
29551628Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri.Exp Parasitol2018
29725596Substrate Specificity of Cysteine Proteases Beyond the S<sub>2</sub> Pocket: Mutagenesis and Molecular Dynamics Investigation of <i>Fasciola hepatica</i> Cathepsins L.Front Mol Biosci2018
29688342Why Funding for Neglected Tropical Diseases Should Be a Global Priority.Clin Infect Dis2018
29565998Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis.PLoS One2018
27977118Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.ACS Chem Biol2017
28440429Cathepsin B expression in colorectal cancer in a Middle East population: Potential value as a tumor biomarker for late disease stages.Oncol Rep2017
28421063Editorial: Drug Development for Parasite-Induced Diarrheal Diseases.Front Microbiol2017
29284029CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).PLoS Negl Trop Dis2017
292816434-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.PLoS Negl Trop Dis2017
28704396Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.PLoS Negl Trop Dis2017
28623818The rule of five should not impede anti-parasitic drug development.Int J Parasitol Drugs Drug Resist2017
28892370Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection.Anal Chem2017
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Collaborators

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 57
Qassim University
Co-authored papers 32
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 31
university of california san diego Health
Co-authored papers 18
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 17
University of California at San Francisco
Co-authored papers 17
The Joint Center for Structural Genomics, Stanford University
Co-authored papers 15
Czech University of Life Sciences
Co-authored papers 13
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 11
University of California san francisco
Co-authored papers 9
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 8
University of California San Francisco
Co-authored papers 6
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 5
Co-authored papers 4
The University of Texas Medical Branch
Co-authored papers 4
St. Jude Children's Research Hospital
Co-authored papers 4
University of California san francisco
Co-authored papers 4
National Centre for Cell Science, SP Pune University Campus
Co-authored papers 4
Co-authored papers 4
School of Public Health, University of California berkeley
Co-authored papers 4
University of California San Francisco
Co-authored papers 3
University of California san francisco
Co-authored papers 3
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
University of California san francisco
Co-authored papers 3
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 3
a division of The Scripps Research Institute La Jolla
Co-authored papers 3
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 3
University of California San Francisco
Co-authored papers 3