| 36837653 | Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor. | Membranes (Basel) | 2023 |
| 37406115 | Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. | Sci Adv | 2023 |
| 36050469 | NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling. | Nat Cell Biol | 2022 |
| 35850480 | Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity. | SLAS Discov | 2022 |
| 32749201 | Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors. | SLAS Discov | 2021 |
| 33545115 | Discovery of small molecule positive allosteric modulators of the secretin receptor. | Biochem Pharmacol | 2021 |
| 33887438 | Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition. | Bioorg Med Chem Lett | 2021 |
| 33798699 | Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. | Bioorg Med Chem Lett | 2021 |
| 34950108 | Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol. | Front Endocrinol (Lausanne) | 2021 |
| 33414172 | Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth. | Cancer Res | 2021 |
| 31575656 | Molecular Inhibitor of QSOX1 Suppresses Tumor Growth <i>In Vivo</i>. | Mol Cancer Ther | 2020 |
| 31953320 | A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors. | J Biol Chem | 2020 |
| 30581133 | Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. | Cell Chem Biol | 2019 |
| 30771432 | Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells. | Cancer Lett | 2019 |
| 30969758 | Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase. | ACS Chem Biol | 2019 |
| 29174347 | Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. | Bioorg Med Chem Lett | 2018 |
| 28543567 | TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. | Hepatology | 2017 |
| 28244987 | Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. | Nat Chem Biol | 2017 |
| 28592560 | Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase. | Sci Transl Med | 2017 |
| 27105284 | p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism that Increases the Enzyme's ATPase Activity. | Cell Chem Biol | 2016 |
| 27316992 | Time-Resolved Fluorescence Assays. | Methods Mol Biol | 2016 |
| 25520375 | Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. | Circulation | 2015 |
| 26158899 | Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. | Oncotarget | 2015 |
| 26075913 | TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response. | PLoS One | 2015 |
| 25631047 | Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. | J Biol Chem | 2015 |
| 25719760 | Design of high-throughput screening assays and identification of a SUMO1-specific small molecule chemotype targeting the SUMO-interacting motif-binding surface. | ACS Comb Sci | 2015 |
| 25428889 | Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. | J Bone Miner Res | 2015 |
| 23886911 | pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. | Methods | 2014 |
| 25124115 | Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. | Bioorg Med Chem Lett | 2014 |
| 24412070 | Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. | Bioorg Med Chem Lett | 2014 |
| 23023104 | Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. | J Biomol Screen | 2013 |
| 23860657 | High-throughput screening for protein tyrosine phosphatase activity modulators. | Methods Mol Biol | 2013 |
| 23860652 | Modulators of intestinal alkaline phosphatase. | Methods Mol Biol | 2013 |
| 23860653 | New activity assays for ENPP1 with physiological substrates ATP and ADP. | Methods Mol Biol | 2013 |
| 23860649 | A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples. | Methods Mol Biol | 2013 |
| 23860645 | Phosphatase high-throughput screening assay design and selection. | Methods Mol Biol | 2013 |
| 22156224 | High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1. | J Biomol Screen | 2012 |
| 23010269 | Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. | Bioorg Med Chem Lett | 2012 |
| 22813531 | Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro. | J Med Chem | 2012 |
| 22737280 | Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. | ACS Chem Neurosci | 2012 |
| 22496096 | High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase. | J Biomol Screen | 2012 |
| 22070201 | Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation. | ACS Chem Biol | 2012 |
| 22034497 | TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors. | J Biomol Screen | 2012 |
| 21245471 | High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4. | J Biomol Screen | 2011 |
| 21802003 | Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. | Chem Biol | 2011 |
| 21539312 | Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. | J Med Chem | 2011 |
| 21503265 | Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids. | ACS Med Chem Lett | 2011 |
| 20031422 | Design and synthesis of selective inhibitors of placental alkaline phosphatase. | Bioorg Med Chem | 2010 |
| 20933419 | Inhibition of Bfl-1 with N-aryl maleimides. | Bioorg Med Chem Lett | 2010 |
| 20657462 | Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening. | Molecules | 2010 |