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Author Details

Matthew D Hirschey
Duke Molecular Physiology Institute, Duke University School of Medicine
2006
83
45
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35157847Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.J Biol Chem2022
35538051Statin therapy inhibits fatty acid synthase via dynamic protein modifications.Nat Commun2022
36163365In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence.NPJ Breast Cancer2022
33466329In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.Cancers (Basel)2021
33798408Discovering the landscape of protein modifications.Mol Cell2021
33168699Sirtuin 5 Is Regulated by the SCF<sup>Cyclin F</sup> Ubiquitin Ligase and Is Involved in Cell Cycle Control.Mol Cell Biol2021
33188857Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.Toxicology2021
33243834A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.J Biol Chem2021
32865009β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.Am J Physiol Endocrinol Metab2020
32691018NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.Nat Metab2020
30442533Sensing Mitochondrial Acetyl-CoA to Tune Respiration.Trends Endocrinol Metab2019
31823815Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.Hum Genomics2019
31851938SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.Cell Rep2019
30937823Cellular energetics and mitochondrial uncoupling in canine aging.Geroscience2019
30644754Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.J Proteome Res2019
30661928Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.Cell Metab2019
28726069Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.J Inherit Metab Dis2018
29972782Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.Cell Rep2018
29769314Ablation of <i>Sirtuin5</i> in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.J Biol Chem2018
29478872Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.Trends Biochem Sci2018
29222328Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.J Biol Chem2018
28542596Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.PLoS One2017
28163307Role of NAD<sup>+</sup> and mitochondrial sirtuins in cardiac and renal diseases.Nat Rev Nephrol2017
28380376SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.Cell Metab2017
28380375A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.Cell Metab2017
28212757A Prob(e)able Route to Lysine Acylation.Cell Chem Biol2017
29107506Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.Cell Metab2017
29044784Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.Angew Chem Int Ed Engl2017
28947253Metabolic control by sirtuins and other enzymes that sense NAD<sup>+</sup>, NADH, or their ratio.Biochim Biophys Acta Bioenerg2017
29063832<i>daf-16</i>/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival.Elife2017
28972174Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.J Biol Chem2017
28724806Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.JCI Insight2017
28804911Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.Alcohol Clin Exp Res2017
26861872Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.J Biol Chem2016
27794142Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.Toxicol Sci2016
27806287Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.Cell Rep2016
27208080From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.Toxicol Sci2016
27479364In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction.Curr Protoc Toxicol2016
27187119Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.Anesthesiology2016
25584487Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.Br J Cancer2015
26590477Designing a broad-spectrum integrative approach for cancer prevention and treatment.Semin Cancer Biol2015
26454069Dysregulated metabolism contributes to oncogenesis.Semin Cancer Biol2015
26294425SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.Diabetes2015
26138757SIRT3 regulates progression and development of diseases of aging.Trends Endocrinol Metab2015
26240137Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.J Biol Chem2015
25717114Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.Mol Cell Proteomics2015
25723162Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.Cell2015
25795660High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.Mol Cell Proteomics2015
24725594Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.Mol Cell2014
25417168SnapShot: Mammalian Sirtuins.Cell2014
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Collaborators

Eric Verdin
Buck Institute for Research on Aging
Co-authored papers 18
Jason W Locasale
Duke University
Co-authored papers 7
Robert D Stevens
Duke Molecular Physiology Institute
Co-authored papers 7
Christopher B Newgard
Duke Molecular Physiology Institute
Co-authored papers 6
Michael J Muehlbauer
Duke University School of Medicine
Co-authored papers 6
Robert V Farese
Harvard T.H. Chan School of Public Health
Co-authored papers 6
Joel N Meyer
Duke University Nicholas School of the Environment.
Co-authored papers 5
Eric S Goetzman
Co-authored papers 4
James R Bain
Duke University Medical Center
Co-authored papers 4
Lee W Jones
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Sudha B Biddinger
Co-authored papers 3
Colin T Shearn
University of Colorado School of Medicine
Co-authored papers 2
Marcia C Haigis
Co-authored papers 2
Raul Mostoslavsky
Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 2
Gregory A Michelotti
Inc. Research Triangle Park
Co-authored papers 2
Yingming Zhao
Co-authored papers 2
David J Orlicky
University of Colorado School of Medicine
Co-authored papers 2
Erik J Soderblom
Center for Genomic and Computational Biology, Duke University
Co-authored papers 2
Sivakama S Bharathi
Co-authored papers 2
Katerina Akassoglou
Gladstone Institute for Neurological Disease San Francisco
Co-authored papers 2
Brad Poore
Co-authored papers 2
John A Capra
Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 2
Martin A Moseley
Center for Genomic and Computational Biology
Co-authored papers 2
Deborah M Muoio
Co-authored papers 2
Costas A Lyssiotis
Co-authored papers 2
Sherman M Weissman
Co-authored papers 1
William C Copeland
National Institute of Environmental Health Sciences, National Institutes of Health
Co-authored papers 1
Thomas E Carey
Kresge Hearing Research Institute, University of Michigan ann arbor
Co-authored papers 1
Daniel T Shaughnessy
National Institute of Environmental Health Sciences, National Institutes of Health
Co-authored papers 1
Philip I Merksamer
University of California san francisco
Co-authored papers 1
Release 1.2