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Author Details

Paul D De Jesus
Sanford Burnham Prebys Medical Discovery Institute
2003
31
20
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35766385Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.ACS Infect Dis2022
33440148MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.Cell Rep2021
33930332Functional landscape of SARS-CoV-2 cellular restriction.Mol Cell2021
34556855Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.Nat Microbiol2021
34468177The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking <i>De Novo</i> Formation of the Membranous Replication Compartment.J Virol2021
34843601A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.PLoS Pathog2021
32511357A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals.bioRxiv2020
31776276Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.J Virol2020
33024967Functional Landscape of SARS-CoV-2 Cellular Restriction.bioRxiv2020
32707573Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.Nature2020
30397075SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway.Mol Cell Biol2019
30717826HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses.Elife2019
29268608Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein.ACS Infect Dis2018
29490283Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu.Cell Rep2018
28248290Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.Nat Microbiol2017
25984567A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.ACS Infect Dis2015
26651948Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.Cell Host Microbe2015
26046437PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.Cell2015
24586659Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.PLoS One2014
24807708RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.J Virol2014
22423970Cofactors required for TLR7- and TLR9-dependent innate immune responses.Cell Host Microbe2012
21949408Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor.Proc Natl Acad Sci U S A2011
20027183Human host factors required for influenza virus replication.Nature2010
20622870Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.Nat Cell Biol2010
18302737Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells.Genome Biol2008
18854154Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.Cell2008
17828270A probability-based approach for the analysis of large-scale RNAi screens.Nat Methods2007
17939994A role for IkappaB kinase 2 in bipolar spindle assembly.Proc Natl Acad Sci U S A2007
16474387A functional genomics approach to the mode of action of apratoxin A.Nat Chem Biol2006
14990790Identification of p53 regulators by genome-wide functional analysis.Proc Natl Acad Sci U S A2004
14514886Genome-scale functional profiling of the mammalian AP-1 signaling pathway.Proc Natl Acad Sci U S A2003
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Collaborators

The Scripps Research Institute
Co-authored papers 31
Icahn School of Medicine at Mount Sinai
Co-authored papers 12
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Co-authored papers 11
The Scripps Research Institute
Co-authored papers 9
Genomics Institute of the Novartis Research Foundation
Co-authored papers 8
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Paul-Ehrlich-Institut
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Co-authored papers 6
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Co-authored papers 6
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Co-authored papers 6
Michigan State University College of Human Medicine
Co-authored papers 6
University of California irvine
Co-authored papers 6
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 5
University of California San Diego
Co-authored papers 5
University of California San Diego
Co-authored papers 5
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
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Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 5
Icahn School of Medicine at Mount Sinai
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Sirna Therapeutics a former subsidiary of Merck & Co., Inc.
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Sanford Burnham Prebys Medical Discovery Institute
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United States Army Medical Research Institute of Infectious Diseases
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Northwestern University Feinberg School of Medicine
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Institute of Medical Virology, University of Zurich
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College of Veterinary Medicine, Oregon State University
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Carlson College of Veterinary Medicine, Oregon State University
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