Skip to Main Content

Author Details

Ignaty Leshchiner
Broad Institute of Massachusetts Institute of Technology and Harvard
2008
53
28
PMIDPaper TitleJournal TitlePublished Year
37916958Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.Cancer Discov2024
36287227Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance.Blood Adv2023
37808694Germline mutations and developmental mosaicism underlying <i>EGFR</i>-mutant lung cancer.medRxiv2023
37024582Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer.Nat Genet2023
37081260Inferring early genetic progression in cancers with unobtainable premalignant disease.Nat Cancer2023
37146250Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples.Blood2023
36624313Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome.Nat Med2023
35243413Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.Cell Rep Med2022
36215125Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor-Positive Breast Cancer.Clin Cancer Res2022
36359386<i>osr1</i> Maintains Renal Progenitors and Regulates Podocyte Development by Promoting <i>wnt2ba</i> via the Antagonism of <i>hand2</i>.Biomedicines2022
34112698Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History.Cancer Discov2021
33684943Activation of the MAPK pathway mediates resistance to PI3K inhibitors in chronic lymphocytic leukemia.Blood2021
34496240Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer.Cell Rep2021
34404686Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer.Cancer Discov2021
34750583The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function.Nat Cell Biol2021
32442065Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression.J Clin Oncol2020
32973110The cationic amino acid exporter Slc7a7 is induced and vital in zebrafish tissue macrophages with sustained efferocytic activity.J Cell Sci2020
32938797Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect.Sci Transl Med2020
31160420Tfap2a is a novel gatekeeper of nephron differentiation during kidney development.Development2019
31745334Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.Nat Med2019
31501609Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.Nat Med2019
31543463Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.Cancer Cell2019
30712845A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion.Cancer Cell2019
31142838Growth dynamics in naturally progressing chronic lymphocytic leukaemia.Nature2019
29713087Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.Nat Med2018
30107175Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.Cancer Cell2018
30131872An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.NPJ Genom Med2018
30123863Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in Lung Cancer.JCO Precis Oncol2018
29955181Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.Nat Med2018
29955182Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.Nat Med2018
30262473Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification".Science2018
29717118Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair.Nat Commun2018
28034880Polyclonal Secondary <i>FGFR2</i> Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.Cancer Discov2017
29872714Resolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatment-resistant autopsy specimens.NPJ Precis Oncol2017
28162975Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.Cancer Cell2017
29109393Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors.Nat Commun2017
29259203The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.Nat Commun2017
28825726A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.Nat Genet2017
28579318The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development.Dev Biol2017
26698910Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.N Engl J Med2016
26493744An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood.Rheumatology (Oxford)2016
27432961Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.Proc Natl Acad Sci U S A2016
27432227Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer.Cancer Discov2016
25341114Summarizing polygenic risks for complex diseases in a clinical whole-genome report.Genet Med2015
26436107Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease.Mol Genet Genomic Med2015
26392535Comprehensive assessment of cancer missense mutation clustering in protein structures.Proc Natl Acad Sci U S A2015
26192918Paired exome analysis of Barrett's esophagus and adenocarcinoma.Nat Genet2015
24667040An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.Genome Biol2014
24130329Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish.Development2013
22555591Mutation mapping and identification by whole-genome sequencing.Genome Res2012
  • 1 - 50 of 53

Recommended Authors

Zachary L Skidmore
Washington University in St. Louis School of Medicine
Career Start Year 2015
Number of shared co-authors 0
Richard de Borja
The Hospital for Sick Children
Career Start Year 2012
Number of shared co-authors 0
Francesco Favero
Universita del Piemonte Orientale
Career Start Year 2010
Number of shared co-authors 0
Natalie J??ger
Hopp Children's Cancer Center Heidelberg (KiTZ)
Career Start Year 2010
Number of shared co-authors 6
Sabah Kadri
Abbvie Inc., Genomics Research Center
Career Start Year 2009
Number of shared co-authors 2
Ken Chen
University of Texas MD Anderson Cancer Center
Career Start Year 2007
Number of shared co-authors 15
David C Wedge
Manchester Cancer Research Centre, University of Manchester
Career Start Year 2006
Number of shared co-authors 4
Barry S Taylor
Memorial Sloan Kettering Cancer Center
Career Start Year 2006
Number of shared co-authors 23
Mark J Cowley
Children's Cancer Institute, Lowy Cancer Research Centre
Career Start Year 2006
Number of shared co-authors 3
Nicola Waddell
QIMR Berghofer Medical Research Institute
Career Start Year 2006
Number of shared co-authors 2
Ann-Marie Patch
QIMR Berghofer Medical Research Institute
Career Start Year 2005
Number of shared co-authors 1
Jamie K Teer
H. Lee Moffitt Cancer Center and Research Institute
Career Start Year 2005
Number of shared co-authors 0
Matthias Schlesner
University of Augsburg
Career Start Year 2004
Number of shared co-authors 5
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Career Start Year 2004
Number of shared co-authors 3
Trevor J Pugh
Princess Margaret Cancer Centre, University Health Network
Career Start Year 2003
Number of shared co-authors 30
Peter J Campbell
Wellcome Sanger Institute
Career Start Year 2003
Number of shared co-authors 10
Obi L Griffith
Washington University
Career Start Year 2003
Number of shared co-authors 9
Peter Van Loo
The Francis Crick Institute
Career Start Year 2003
Number of shared co-authors 3
Olivier Harismendy
University of California
Career Start Year 2003
Number of shared co-authors 2
Jianhua Zhang
University of Texas MD Anderson Cancer Center
Career Start Year 2003
Number of shared co-authors 17
Malachi Griffith
Washington University
Career Start Year 2003
Number of shared co-authors 9
Olivier Elemento
Meyer Cancer Center
Career Start Year 2002
Number of shared co-authors 19
Vladimir Makarov
Center for Immunotherapy and Precision-Immuno-Oncology, Cleveland Clinic
Career Start Year 2001
Number of shared co-authors 8
Luciano G Martelotto
Monash University
Career Start Year 2000
Number of shared co-authors 2
Kenna R Mills Shaw
The University of Texas MD Anderson Cancer Center
Career Start Year 1999
Number of shared co-authors 12
Colin C Pritchard
University of Washington, USA Brotman Baty Institute for Precision Medicine
Career Start Year 1999
Number of shared co-authors 13
Carrie Sougnez
The Broad Institute of Harvard and MIT
Career Start Year 1998
Number of shared co-authors 39
Li Ding
McDonnell Genome Institute, Washington University School of Medicine
Career Start Year 1997
Number of shared co-authors 18
Jinghui Zhang
Changhai Hospital, Second Military Medical University
Career Start Year 1992
Number of shared co-authors 12
Elaine R Mardis
The Ohio State University
Career Start Year 1988
Number of shared co-authors 31

Collaborators

Gad Getz
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 35
Dimitri Livitz
Co-authored papers 18
Daniel Rosebrock
Co-authored papers 14
Chip Stewart
Broad Institute of MIT and Harvard
Co-authored papers 13
Donna Neuberg
Co-authored papers 10
Jaegil Kim
Co-authored papers 9
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 8
Amaro Taylor-Weiner
Co-authored papers 8
Julian M Hess
Broad Institute of MIT and Harvard
Co-authored papers 7
Kahn Rhrissorrakrai
T.J. Watson Research Center
Co-authored papers 7
Michael S Lawrence
Co-authored papers 7
Anthony J Iafrate
Massachusetts General Hospital
Co-authored papers 7
Catherine J Wu
Co-authored papers 7
Atanas Kamburov
Broad Institute of Harvard and MIT
Co-authored papers 6
Paz Polak
McGill University
Co-authored papers 6
Thomas J Kipps
University of California San Diego
Co-authored papers 5
Laura Z Rassenti
University of California San Diego
Co-authored papers 5
Dora Dias-Santagata
Co-authored papers 5
Shamil R Sunyaev
Harvard Medical School
Co-authored papers 5
Matthew Meyerson
Broad Institute
Co-authored papers 5
François Aguet
Co-authored papers 4
Mara Rosenberg
Broad Institute of MIT and Harvard
Co-authored papers 4
Samuel S Freeman
St Vincent's Hospital Melbourne
Co-authored papers 4
Nathan O Stitziel
Co-authored papers 4
Soumya Raychaudhuri
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 3
Chandra Sekhar Pedamallu
Broad Institute
Co-authored papers 3
Jeremiah Wala
The Broad Institute of MIT and Harvard
Co-authored papers 3
Reiner Siebert
Co-authored papers 3
Adam Tracy
Co-authored papers 3
Jochen K Lennerz
Massachusetts General Hospital/Harvard Medical School
Co-authored papers 3
Release 1.2