Author details

Full Name

Ari Melnick

Affiliation

ORCID

Career Start Year

1996

Papers

346

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37546906	ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.		2023
36346827	Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies.		2023
36264161	An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas.	Cancer Discov	2023
35981563	Endothelial cell-leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities.	Blood	2023
37937078	Depletion of <i>tet2</i> results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome.	Front Hematol	2023
37767562	Profiling the activity of the para-caspase MALT1 in B-cell acute lymphoblastic leukemia for potential targeted therapeutic application.		2023
36656933	BTG1 mutation yields supercompetitive B cells primed for malignant transformation.	Science	2023
36652477	Distinct and opposite effects of leukemogenic <i>Idh</i> and <i>Tet2</i> mutations in hematopoietic stem and progenitor cells.	Proc Natl Acad Sci U S A	2023
37021547	Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid Î²-oxidation and inducing lipotoxicity.	Haematologica	2023
36824887	Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas.	bioRxiv	2023
36796016	Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL.	Blood	2023
36928381	Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas.	Nat Mater	2023
36736318	IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.	Cancer Cell	2023
35223844	Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms.	Front Cell Dev Biol	2022
35459639	Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants.	Biophysical Journal	2022
36167829	TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.	Nature Communications	2022
35443279	SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.	Cancer Discov	2022
35380993	Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma.	J Clin Invest	2022
35637420	Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer sequencing.	Nat Biotechnol	2022
36151075	Integrative analysis identifies an older female-linked AML patient group with better risk in ECOG-ACRIN Cancer Research Group's clinical trial E3999.	Blood Cancer J	2022
36001803	Genomic profiling for clinical decision making in lymphoid neoplasms.	Blood	2022
35550952	3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis.	Current Opinion in Genetics and Development	2022
35793628	Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response.	Cell Reports	2022
35917283	Tee-ing up a New Follicular Lymphoma Classification System.		2022
35851487	Taking the EZ way: Targeting enhancer of zeste homolog 2 in B-cell lymphomas.	Blood Reviews	2022
35233546	System-wide transcriptome damage and tissue identity loss in COVID-19 patients.	Cell Rep Med	2022
34783281	Targeting MALT1 for the treatment of diffuse large B-cell lymphoma.	Leukemia and Lymphoma	2022
34961980	Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts.	Am J Hematol	2022
35019856	Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival.		2022
34957890	Loss of function mutations of in classical Hodgkin lymphoma.	Leukemia and Lymphoma	2022
35087231	Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes.	Nature Immunology	2022
35263148	Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia.	Sci Transl Med	2022
34872606	The SEQC2 epigenomics quality control (EpiQC) study.	Genome Biol	2021
33972667	Gene expression derived from alternative promoters improves prognostic stratification in multiple myeloma.	Leukemia	2021
33541860	Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures.	Cancer Discov	2021
33580203	Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.	Leukemia	2021
33895809	Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL.	Blood	2021
33844535	Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.	Journal of Medicinal Chemistry	2021
33786580	KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas.	Blood	2021
33567281	Clonal hematopoiesis before, during, and after human spaceflight.	Cell Rep	2021
34151238	Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.	iScience	2021
33831168	Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML.	Blood	2021
33447829	An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities.	Blood Cancer Discov	2021
33758858	Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps.	bioRxiv	2021
33712587	Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions.	Nat Commun	2021
33597729	Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma.	Leukemia	2021
33500244	Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence.	Cancer Discov	2021
33816475	An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions.	Front Cell Dev Biol	2021
33299182	H1 histones control the epigenetic landscape by local chromatin compaction.	Nature	2021
32911532	BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.	Blood	2021