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Author Details

Matthew Clarke
2012
34
24
PMIDPaper TitleJournal TitlePublished Year
34850536FGF7-FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas.Mol Oncol2022
34737188DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition.Cancer Discovery2022
34753775HER3 Is an Actionable Target in Advanced Prostate Cancer.Cancer Res2021
34169282Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients.Neurooncol Adv2021
33900873High grade gliomas in young children: The South Thames Neuro-Oncology unit experience and recent advances in molecular biology and targeted therapies.Pediatric Hematology and Oncology2021
32595135Noninvasive MRI Native T<sub>1</sub> Mapping Detects Response to <i>MYCN</i>-targeted Therapies in the Th-<i>MYCN</i> Model of Neuroblastoma.Cancer Res2020
31786093DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study.Lancet Child Adolesc Health2020
32238360Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.Cancer Discov2020
31874108Genomics of lethal prostate cancer at diagnosis and castration resistance.J Clin Invest2020
31806540Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial.Lancet Oncol2020
31098401ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.Commun Biol2019
30615140Corrigendum: Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.Hum Mol Genet2019
30877107MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment.Cancer Res2019
31543384A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.Eur J Cancer2019
30885698Identification of new Wilms tumour predisposition genes: an exome sequencing study.2019
29555663Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC).Clin Cancer Res2018
30068710SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity.Clin Cancer Res2018
29973717CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.Nature2018
29967352Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.Nat Med2018
30382943Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer.J Clin Invest2018
30042009Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer.Clin Colorectal Cancer2018
30179225Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer.J Clin Invest2018
29348602The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion.Scientific Reports2018
28966033Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.Cancer Cell2017
28553959Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.Nature Genetics2017
28450425Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.Cancer Discov2017
28475857Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability.Am J Hum Genet2017
27485037OpEx - a validated, automated pipeline optimised for clinical exome sequence analysis.Scientific Reports2016
28459104Accurate clinical detection of exon copy number variants in a targeted NGS panel using DECoN.Wellcome Open Research2016
26315209CSN and CAVA: variant annotation tools for rapid, robust next-generation sequencing analysis in the clinical setting.Genome Medicine2015
25972378Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.Hum Mol Genet2015
26834991The ICR1000 UK exome series: a resource of gene variation in an outbred population.F1000Research2015
23098902Characterization of Arabidopsis serine:glyoxylate aminotransferase, AGT1, as an asparagine aminotransferase.Phytochemistry2013
22891909More than an education: the hidden curriculum, professional attitudes and career choice.Medical Education2012
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