Author details

Full Name

Leslie M Thompson

Affiliation

ORCID

Career Start Year

1980

Papers

143

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36864071	Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.	Nat Commun	2023
37961595	Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification.		2023
37863037	HD and SCA1: Tales from two 30-year journeys since gene discovery.		2023
36510111	An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models.	Nat Neurosci	2023
36764301	Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects.	Neuron	2023
36547263	An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.	Hum Mol Genet	2023
35262656	Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder.	Brain	2022
36590162	Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits.	iScience	2022
36543778	Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.	Nat Commun	2022
34982109	Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins.	Journal of Cell Science	2022
35253772	Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes.	Journal of Huntington's disease	2022
35115730	Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines.	Nat Neurosci	2022
34935438	Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice.	Journal of Virology	2022
34816260	Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice.		2021
33749919	Cell Therapy for Huntington's Disease: Learning from Failure.	Mov Disord	2021
33945510	Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization.	J Clin Invest	2021
34866144	A Scoping Review of Dietary Factors Conferring Risk or Protection for Cognitive Decline in APOE Îµ4 Carriers.	Journal of Nutrition, Health and Aging	2021
34786551	Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease.	Matrix Biology Plus	2021
32984268	Calcium Dynamics in Astrocytes During Cell Injury.	Frontiers in Bioengineering and Biotechnology	2020
31696228	Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice.	Human Molecular Genetics	2020
31848580	Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease.	Brain	2020
32109367	Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation.	Stem Cell Reports	2020
30994454	Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.	Elife	2019
31612586	A short note for Mike.	Journal of Neuroscience Research	2019
31088970	IKKÎ² slows Huntington's disease progression in R6/1 mice.	Proc Natl Acad Sci U S A	2019
29843246	Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.	Journal of Huntington's disease	2018
28986324	The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.	Neurobiol Dis	2018
30452420	Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice.	Journal of Huntington's disease	2018
29856014	Cellular Models: HD Patient-Derived Pluripotent Stem Cells.	Methods in Molecular Biology	2018
29311338	Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes.	Proceedings of the National Academy of Sciences of the United States of America	2018
29566793	Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.	Neuron	2018
29553509	Fractionation for Resolution of Soluble and Insoluble Huntingtin Species.	Journal of Visualized Experiments	2018
29512295	Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings.	CNS Neuroscience and Therapeutics	2018
29199020	The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.	Cell Syst	2018
29233555	Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice.	Stem Cell Reports	2018
28225193	Human Neural Progenitor Transplantation Rescues Behavior and Reduces Î±-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.	Stem cells translational medicine	2017
28384479	Mutant Huntingtin Disrupts the Nuclear Pore Complex.	Neuron	2017
28533375	KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.	Proc Natl Acad Sci U S A	2017
28526555	Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier.	Cell Stem Cell	2017
28968246	Introducing the "Clinical Trials Corner".	Journal of Huntington's disease	2017
28514657	Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.	Cell Reports	2017
29116112	A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.	Sci Rep	2017
27601642	TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.	Proc Natl Acad Sci U S A	2016
27427231	SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.	Cell Chem Biol	2016
27146268	PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes InÂ Vivo.	Neuron	2016
26100538	Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin.	Mol Psychiatry	2015
25398943	Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.	Human Molecular Genetics	2015
25556834	Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.	Neuron	2015
24466111	Fibroblast growth factor receptor 3 interacts with and activates TGFÎ²-activated kinase 1 tyrosine phosphorylation and NFÎºB signaling in multiple myeloma and bladder cancer.	PLoS ONE	2014
25575954	Comparison of phosphodiesterase 10A, dopamine receptors D1 and D2 and dopamine transporter ligand binding in the striatum of the R6/2 and BACHD mouse models of Huntington's disease.	Journal of Huntington's disease	2014