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Author Details

Richard L Stevens
School of Biomedical Sciences and Pharmacy, University of Newcastle
1966
217
73
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
28193842Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5.J Biol Chem2017
26982501CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.PLoS One2016
25330932Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.Arthritis Rheumatol2015
24523504Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions.J Immunol2014
25219118Mast cell-derived htryptase-beta functions as a potent anticoagulant by proteolytically damaging fibrinogen.J Investig Allergol Clin Immunol2014
25401721The multifaceted mast cell in inflammatory bowel disease.Inflamm Bowel Dis2014
25094046Ancient origin of mast cells.Biochem Biophys Res Commun2014
24745673Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation.Immunol Allergy Clin North Am2014
24821729Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.J Biol Chem2014
24507159Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.Adv Immunol2014
23380220A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.J Allergy Clin Immunol2013
23797671Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens.J Immunol2013
22235124Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen.J Biol Chem2012
25102006Programming of the lung by early-life infection.J Dev Orig Health Dis2012
23071771Interleukin-33 primes mast cells for activation by IgG immune complexes.PLoS One2012
22525013The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite.Immunol Lett2012
22511759Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.J Biol Chem2012
21173247Essential role for mast cell tryptase in acute experimental colitis.Proc Natl Acad Sci U S A2011
21493897Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.Circ Res2011
20427273Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).J Biol Chem2010
21076070The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.J Immunol2010
19109198Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.J Immunol2009
19720934Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.Circulation2009
19408317Stress in the ER leads to inflammatory bowel disease.Inflamm Bowel Dis2009
18024961The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.J Biol Chem2008
18668540The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis.Arthritis Rheum2008
17456473The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.J Biol Chem2007
17878389Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus.J Immunol2007
17504754Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense.J Biol Chem2007
17405882Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.J Biol Chem2007
17498058Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.Immunol Rev2007
16144798Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor.Blood2006
15701722Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.Blood2005
16605128RasGRP4 in mast cell signalling and disease susceptibility.Novartis Found Symp2005
16143303Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases.Biochem Biophys Res Commun2005
15905575Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.J Immunol2005
15785821Ring fission of chiral cyclic acetals plus intramolecular [4 + 2] cycloaddition: a sequential access to medium-size lactones. Application to the synthesis of carbasugars.Org Biomol Chem2005
14583634Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns.J Biol Chem2004
12493770RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.J Biol Chem2003
14528917Characterization of a recombinant molecule covalently indistinguishable from human cerebroside-sulfate activator protein (CSAct or Saposin B).Cell Mol Biol (Noisy-le-grand)2003
12646205Mouse mast cells express the tryptic protease neuropsin/Prss19.Biochem Biophys Res Commun2003
12817022Mast cells in airway hyporesponsive C3H/HeJ mice express a unique isoform of the signaling protein Ras guanine nucleotide releasing protein 4 that is unresponsive to diacylglycerol and phorbol esters.J Immunol2003
11937573IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1.J Immunol2002
12194977Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway.J Biol Chem2002
12217396Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors.Mol Immunol2002
12433372Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.Immunity2002
11956218RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function.J Biol Chem2002
11602603Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells.J Biol Chem2001
11369641Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4.Blood2001
11259427Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases.J Biol Chem2001
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Collaborators

Brigham & Women's Hospital
Co-authored papers 89
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 27
Harvard Medical School
Co-authored papers 21
Harvard Medical School
Co-authored papers 21
University of NSW
Co-authored papers 20
Johns Hopkins University School of Medicine
Co-authored papers 19
The University of Texas MD Anderson Cancer Center
Co-authored papers 14
Inc. 10555 Stella link
Co-authored papers 13
University of California San Francisco
Co-authored papers 12
Cincinnati Children's Hospital Medical Center
Co-authored papers 11
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 11
Co-authored papers 9
Co-authored papers 8
Tokyo Medical and Dental University
Co-authored papers 8
Co-authored papers 7
School of Pharmacy, East China University of Science and Technology
Co-authored papers 6
Harvard Medical School
Co-authored papers 6
Atopy Research Center, Juntendo University Graduate School of Medicine
Co-authored papers 5
Indian Institute of Science Education and Research Pune
Co-authored papers 4
Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital
Co-authored papers 4
Toranomon Hospital
Co-authored papers 4
Co-authored papers 4
College of Life Science and Engineering, Foshan University
Co-authored papers 4
University of New South Wales
Co-authored papers 3
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Schrodinger Inc.
Co-authored papers 3
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Institut Curie
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Concord Repatriation General Hospital
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