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Author Details

Alan R Davidson
University of Toronto, University Avenue
1980
146
56
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36927736A contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor.Nat Commun2023
36958604Ten Years of Anti-CRISPR Research.J Mol Biol2023
37315746Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression.J Heart Lung Transplant2023
37140042Core defense hotspots within Pseudomonas aeruginosa are a consistent and rich source of anti-phage defense systems.Nucleic Acids Res2023
37330527Complete genomes and comparative analyses of Streptomyces phages that influence secondary metabolism and sporulation.Sci Rep2023
37260386F-Type Pyocins Are Diverse Noncontractile Phage Tail-Like Weapons for Killing <i>Pseudomonas aeruginosa</i>.J Bacteriol2023
36888656Diverse yeast antiviral systems prevent lethal pathogenesis caused by the L-A mycovirus.Proc Natl Acad Sci U S A2023
36736884Anti-CRISPR Protein AcrIIC5 Inhibits CRISPR-Cas9 by Occupying the Target DNA Binding Pocket.J Mol Biol2023
34826709Identification of the tail assembly chaperone genes of T4-Like phages suggests a mechanism other than translational frameshifting for biogenesis of their encoded proteins.Virology2022
35780695The small genome, virulent, non-contractile tailed bacteriophages that infect Enterobacteriales hosts.Virology2022
34954237Structural and Mechanistic Insight into CRISPR-Cas9 Inhibition by Anti-CRISPR Protein AcrIIC4<sub>Hpa</sub>.J Mol Biol2022
33412111A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.Mol Cell2021
33660777Anti-CRISPR AcrIF9 functions by inducing the CRISPR-Cas complex to bind DNA non-specifically.Nucleic Acids Res2021
33338493Anti-CRISPR AcrIE2 Binds the Type I-E CRISPR-Cas Complex But Does Not Block DNA Binding.J Mol Biol2021
33139482Phage Proteins Required for Tail Fiber Assembly Also Bind Specifically to the Surface of Host Bacterial Strains.J Bacteriol2021
32483187AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.Nat Commun2020
32186918Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems.Annu Rev Biochem2020
32325050Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes.Cell Host Microbe2020
30471255Allosteric Modulation of Binding Specificity by Alternative Packing of Protein Cores.J Mol Biol2019
31722192Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing.Cell Rep2019
31474367Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription.Cell2019
31243272Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.Nat Commun2019
31209305Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres.Nat Microbiol2019
29062071Anti-CRISPR: discovery, mechanism and function.Nat Rev Microbiol2018
30150232Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes.J Bacteriol2018
31021273A Unified Resource for Tracking Anti-CRISPR Names.CRISPR J2018
30514786Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.mBio2018
30478386Type VI secretion system baseplate.Nat Microbiol2018
30309931A common trick for transferring bacterial DNA.Science2018
29133883Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation.Nat Microbiol2018
28844692A Broad-Spectrum Inhibitor of CRISPR-Cas9.Cell2017
28340349Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.Cell2017
28099417Virology: Phages make a group decision.Nature2017
29233895Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein.mBio2017
29046529Cheese, phages and anti-CRISPRs.Nat Microbiol2017
28749735The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs.Annu Rev Virol2017
28668720Inhibition of CRISPR-Cas systems by mobile genetic elements.Curr Opin Microbiol2017
27573108Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species.Nat Microbiol2016
27984730Naturally Occurring Off-Switches for CRISPR-Cas9.Cell2016
27725669The solution structure of an anti-CRISPR protein.Nat Commun2016
27555589Baseplate assembly of phage Mu: Defining the conserved core components of contractile-tailed phages and related bacterial systems.Proc Natl Acad Sci U S A2016
27258950Prophages mediate defense against phage infection through diverse mechanisms.ISME J2016
25532427The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E.â¿¿coli phage HK97.Mol Microbiol2015
26586803Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery.Nucleic Acids Res2015
26416740Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.Nature2015
25644660A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae.J Mol Biol2015
25772450Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense.Curr Biol2015
23933057A shifty chaperone for phage tail assembly.J Mol Biol2014
24736222A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa.mBio2014
24585054When a virus is not a parasite: the beneficial effects of prophages on bacterial fitness.J Microbiol2014
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Collaborators

Joseph Bondy-Denomy
University of California san francisco
Co-authored papers 21
Aled M Edwards
University of Toronto
Co-authored papers 9
Lewis E Kay
University of Toronto
Co-authored papers 7
Erik J Sontheimer
Co-authored papers 7
Megha Shah
University of Toronto, University Avenue
Co-authored papers 5
Trevor F Moraes
University of Toronto, University Avenue
Co-authored papers 5
Sabrina Y Stanley
University of Toronto, University Avenue
Co-authored papers 4
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 4
Julie D Forman-Kay
Hospital for Sick Children
Co-authored papers 4
Ingo Ruczinski
Co-authored papers 3
Dmitry M Korzhnev
University of Connecticut Health Center
Co-authored papers 3
Jennifer A Doudna
Innovative Genomics Institute, University of California berkeley
Co-authored papers 3
Adelinda Yee
University of Toronto
Co-authored papers 3
Brenda J Andrews
University of Toronto
Co-authored papers 3
Alexei Savchenko
University of Toronto
Co-authored papers 2
James S Fraser
University of California san francisco
Co-authored papers 2
Gabriel C Lander
The Scripps Research Institute
Co-authored papers 2
Kevin P Battaile
Co-authored papers 2
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 2
David Baker
University of Washington
Co-authored papers 2
Adair L Borges
Innovative Genomics Institute, University of California berkeley
Co-authored papers 2
Jennifer Haynes
Joan C. Edwards School of Medicine, Marshall University
Co-authored papers 2
Benjamin P Kleinstiver
Center for Genomic Medicine, Massachusetts General Hospital
Co-authored papers 2
Kyle C Cady
Massachusetts Institute of Technology
Co-authored papers 1
Mandy H Y Lam
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
Elizabeth R Fischer
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Chris A Kaiser
Massachusetts Institute of Technology
Co-authored papers 1
Viktor Deineko
University of Northern British Columbia
Co-authored papers 1
James W Dennis
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University Avenue R988
Co-authored papers 1
John Parkinson
The Hospital for Sick Children
Co-authored papers 1
Release 1.2