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Author Details

Tom J Brett
2000
48
31
PMIDPaper TitleJournal TitlePublished Year
35998009Production of Eukaryotic Glycoproteins for Structural and Functional Studies Using Expi293F Cells.Current Protocols2022
34559985Lrp1 is a host entry factor for Rift Valley fever virus.Cell2021
33090700Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42.Alzheimers Dement2020
31995732Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.Cell Reports2020
31413141The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.Sci Transl Med2019
30592210The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer.Biochemistry2019
30113067Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps.BioEssays2018
30355735YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.Journal of Biological Chemistry2018
27899611The ExAC browser: displaying reference data information from over 60 000 exomes.Nucleic Acids Res2017
28432014TREM2-Ligand Interactions in Health and Disease.Journal of Molecular Biology2017
28420732Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).Journal of Biological Chemistry2017
27535533Analysis of protein-coding genetic variation in 60,706 humans.Nature2016
26756551Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.British Journal of Pharmacology2016
27369736First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.2016
26947396Data publication with the structural biology data grid supports live analysis.Nat Commun2016
27995897Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.eLife2016
26293662Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol deficiencies.Hum Mol Genet2015
25781344Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.eLife2015
25654555Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.J Clin Invest2015
25897174TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.Journal of Experimental Medicine2015
25849390The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.2015
26780656Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization.Journal of Visualized Experiments2015
26612971Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.Mediators of Inflammation2015
26479788PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.Nature Immunology2015
26296094CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.2015
25250574Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.J Clin Invest2014
24847005Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Hum Mol Genet2014
24508568Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.Protein Expression and Purification2014
25121748Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.Cell Host Microbe2014
23274150BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.Molecular Immunology2013
23902945Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency.J Clin Endocrinol Metab2013
23963447Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.Journal of Biological Chemistry2013
23187130IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.Journal of Clinical Investigation2012
22762444Do GGA adaptors bind internal DXXLL motifs?Traffic2012
22513993INRICH: interval-based enrichment analysis for genome-wide association studies.Bioinformatics2012
23112050Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.Journal of Biological Chemistry2012
21321118Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.Journal of Biological Chemistry2011
21084286Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release.Journal of Biological Chemistry2011
18954282The role of CLCA proteins in inflammatory airway disease.Annual Review of Physiology2009
16806884Molecular structures of coat and coat-associated proteins: function follows form.Current Opinion in Cell Biology2006
16415883Structural definition of the F-actin-binding THATCH domain from HIP1R.Nature Structural and Molecular Biology2006
14704793N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.Nature Immunology2004
15292237Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage.J Biol Chem2004
12057195Accessory protein recruitment motifs in clathrin-mediated endocytosis.Structure2002
11943858Chiral discrimination in cyclodextrin complexes of amino acid derivatives: beta-cyclodextrin/N-acetyl-L-phenylalanine and N-acetyl-D-phenylalanine complexes.Proceedings of the National Academy of Sciences of the United States of America2002
12419245Structural basis of chemokine sequestration by a herpesvirus decoy receptor.Cell2002
11577110Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.Journal of Biological Chemistry2001
12526480Synthesis, characterization, crystal structures, and reactions of trigonal bipyramidal tin(IV) complexes containing, a tetradentate tripodal tristhiolatophosphine ligand. Use in the one-step synthesis of an iron(IV) complex.Inorganic Chemistry2000
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