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Author Details

Jae K Ryu
Gladstone Institutes
2001
77
46
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37291385Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.Nat Immunol2023
33318667Microglial G<sub>i</sub>-dependent dynamics regulate brain network hyperexcitability.Nat Neurosci2021
33608067Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma.Am J Pathol2021
34671772SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy.bioRxiv2021
34426831BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis.Brain2021
32284594Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.Nat Immunol2020
32661365Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.Nat Immunol2020
31076569A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.Transl Psychiatry2019
31068461Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.Proc Natl Acad Sci U S A2019
30737131Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.Neuron2019
29618808Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.Nat Rev Neurosci2018
30323343Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.Nat Immunol2018
29688408Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.Brain2018
28783731Metabolic control of T<sub>H</sub>17 and induced T<sub>reg</sub> cell balance by an epigenetic mechanism.Nature2017
28275164Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.J Neurosci2017
28298456Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.J Exp Med2017
29103804Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.Neuron2017
27073744Pyruvate blocks blood-brain barrier disruption, lymphocyte infiltration and immune response in excitotoxic brain injury.Am J Neurodegener Dis2016
26748707p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.Cell Rep2016
25365546Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.Mol Med2015
26353940Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.Nat Commun2015
26255110Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease.J Neuroinflammation2015
26213713Hypoxia Inducible Factor-1<i>α</i> in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating DiseaseeNeuro2015
26120963Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.Nat Neurosci2015
25918343SIRT1 deacetylates RORγt and enhances Th17 cell generation.J Exp Med2015
25987725SIRT1 deacetylates RORγt and enhances Th17 cell generation.J Exp Med2015
24740641Early detection of thrombin activity in neuroinflammatory disease.Ann Neurol2014
23534534Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease.Curr Alzheimer Res2013
24146937Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells.PLoS One2013
21946335Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease.Neurobiol Dis2012
23187627Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.Nat Commun2012
22998876Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.Neuron2012
21157381Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model.J Neuropathol Exp Neurol2011
22190370Resolving postoperative neuroinflammation and cognitive decline.Ann Neurol2011
21841251Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo.J Alzheimers Dis2011
21969915Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain.Int J Alzheimers Dis2011
20346117Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.BMC Neurosci2010
20704556Converging perturbed microvasculature and microglial clusters characterize Alzheimer disease brain.Curr Alzheimer Res2010
20191045Neurotoxicity screening in a multipotent neural stem cell line established from the mouse brain.J Korean Med Sci2010
20427645Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage.J Neurosci2010
18657226A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain.J Cell Mol Med2009
20030829Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain.J Neuroinflammation2009
19630789Fibrinogen signal transduction in the nervous system.J Thromb Haemost2009
19591904Thalidomide inhibition of vascular remodeling and inflammatory reactivity in the quinolinic acid-injected rat striatum.Neuroscience2009
19115379Lysophosphatidylcholine induces glial cell activation: role of rho kinase.Glia2009
19129379Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology.J Neurosci2009
18039556Expression and function of the P2X(7) receptor in rat C6 glioma cells.Cancer Lett2008
18855589Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain.Curr Alzheimer Res2008
18852683Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease.Neuroreport2008
18492281VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult.J Neuroinflammation2008
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Collaborators

Katerina Akassoglou
Gladstone Institute for Neurological Disease San Francisco
Co-authored papers 28
Andrew S Mendiola
The University of Texas at San Antonio
Co-authored papers 9
Anke Meyer-Franke
Gladstone Institutes
Co-authored papers 7
Mark H Ellisman
National Center for Microscopy and Imaging Research, University of California
Co-authored papers 7
Zhaoqi Yan
University of Illinois College of Medicine Rockford
Co-authored papers 6
Scott S Zamvil
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 6
Alexander R Pico
Institute of Data Science and Biotechnology, Gladstone Institutes
Co-authored papers 5
Reuben Thomas
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes
Co-authored papers 5
Rosa Meza-Acevedo
Gladstone Institutes
Co-authored papers 4
Hans Lassmann
Co-authored papers 4
Eric A Bushong
University of California San Diego (university of california san diego)
Co-authored papers 3
Kristina Hanspers
Gladstone Institutes
Co-authored papers 3
Belinda Cabriga
Gladstone Institutes
Co-authored papers 3
Herbert G Kasler
Buck Institute for Research on Aging
Co-authored papers 2
Hiroyuki Hakozaki
University of California
Co-authored papers 2
Melanie Ott
Gladstone Institute of Virology
Co-authored papers 2
Thomas J Deerinck
National Center for Microscopy and Imaging Research, University of California
Co-authored papers 2
Tony Wyss-Coray
Stanford University
Co-authored papers 2
Karuna Dixit
Gladstone Institutes
Co-authored papers 2
Benoit G Bruneau
Gladstone Institutes of Cardiovascular Disease, Gladstone Institutes
Co-authored papers 2
Niccol?? Terrando
Duke University Medical Center
Co-authored papers 2
Birgit Schilling
Buck Institute for Research on Aging
Co-authored papers 2
Bradford W Gibson
The Buck Institute for Research on Aging
Co-authored papers 2
Eric Verdin
Buck Institute for Research on Aging
Co-authored papers 2
Lennart Mucke
Gladstone Institute of Neurological Disease, Gladstone Institutes
Co-authored papers 2
Kotaro Shirakawa
Graduate School of Medicine, Kyoto University
Co-authored papers 2
Hye-Sook Kwon
Stanford University School of Medicine
Co-authored papers 2
Hyung W Lim
Gladstone Institute of Virology and Immunology
Co-authored papers 2
Mingjian Fei
Genentech Inc.
Co-authored papers 2
Steven L Gonias
University of California san francisco
Co-authored papers 2
Release 1.2