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Author Details

Matthew J Smalley
European Cancer Stem Cell Research Institute, Cardiff University
1998
90
40
PMIDPaper TitleJournal TitlePublished Year
36936664Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models.Cancer Res Commun2023
37686600NOTCH and AKT Signalling Interact to Drive Mammary Tumour Heterogeneity.Cancers (Basel)2023
37231594Epidemiology of mammary tumours in bitches under veterinary care in the UK in 2016.Vet Rec2023
37365662Dog breeds and conformations predisposed to osteosarcoma in the UK: a VetCompass study.Canine Med Genet2023
36961631Associations Between Dog Breed and Clinical Features of Mammary Epithelial Neoplasia in Bitches: an Epidemiological Study of Submissions to a Single Diagnostic Pathology Centre Between 2008-2021.J Mammary Gland Biol Neoplasia2023
34896918Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips.Biosens Bioelectron2022
34003256Reproductive history determines Erbb2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model.Dis Model Mech2021
33750475Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study.Canine Med Genet2021
34503160A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells.Cancers (Basel)2021
31566837Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications.Adv Mater2020
34220409Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies.Adv Funct Mater2020
32017048Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases.Clin Pharmacol Ther2020
33097539Supramolecular nanosubstrate-mediated delivery system enables CRISPR-Cas9 knockin of hemoglobin beta gene for hemoglobinopathies.Sci Adv2020
32637655Somatic copy number profiling from hepatocellular carcinoma circulating tumor cells.NPJ Precis Oncol2020
32630372The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.Int J Mol Sci2020
32793804Integrating single-cell RNA-sequencing and functional assays to decipher mammary cell states and lineage hierarchies.NPJ Breast Cancer2020
33023965Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection.Cancer Immunol Res2020
32895384Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring.Nat Commun2020
31080552Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in <i>Brca2</i>-mutant mammary tumours.Oncotarget2019
31291912APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.BMC Cancer2019
31565541Noninvasive Prenatal Diagnostics: Recent Developments Using Circulating Fetal Nucleated Cells.Curr Obstet Gynecol Rep2019
31392269Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells.Sci Adv2019
30892008Bio-Inspired NanoVilli Chips for Enhanced Capture of Tumor-Derived Extracellular Vesicles: Toward Non-Invasive Detection of Gene Alterations in Non-Small Cell Lung Cancer.ACS Appl Mater Interfaces2019
29551650NanoVelcro rare-cell assays for detection and characterization of circulating tumor cells.Adv Drug Deliv Rev2018
30590041Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.Cell Rep2018
29581176Identification of <i>Pik3ca</i> Mutation as a Genetic Driver of Prostate Cancer That Cooperates with <i>Pten</i> Loss to Accelerate Progression and Castration-Resistant Growth.Cancer Discov2018
28870991The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.Development2017
29446000See One, Do One, Teach One: A Practical Course on Methods in Mammary Gland Biology.J Mammary Gland Biol Neoplasia2017
29262329PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.Cell Rep2017
29134654PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.J Pathol2017
27782124Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.Nat Commun2016
26650685Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression.Biomaterials2016
25803307Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.PLoS One2015
26489514Runx2 contributes to the regenerative potential of the mammary epithelium.Sci Rep2015
26331886Overview of Genetically Engineered Mouse Models of Breast Cancer Used in Translational Biology and Drug Development.Curr Protoc Pharmacol2015
26193872ERrrr⿦where are the progenitors? Hormone receptors and mammary cell heterogeneity.J Mammary Gland Biol Neoplasia2015
25849541Mouse mammary stem cells express prognostic markers for triple-negative breast cancer.Breast Cancer Res2015
25692405Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours.J Pathol2015
24586114Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.PLoS Biol2014
24615332Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.J Pathol2014
22554712Breast cancer stem cells: obstacles to therapy.Cancer Lett2013
24286369Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.Breast Cancer Res2013
23810554Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner.Cell Rep2013
23506684Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers.Breast Cancer Res2013
23154416Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation.Development2013
22562252Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.Oncogene2013
21765473c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.Oncogene2012
23227978Who do they think they are? Wnt-responsive cells reveal their family trees.Breast Cancer Res2012
22971267Slugging their way to immortality: driving mammary epithelial cells into a stem cell-like state.Breast Cancer Res2012
22975324Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.Dev Cell2012
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Collaborators

Alan Ashworth
UCSF Helen Diller Family Comprehensive Cancer Center
Co-authored papers 11
Hsian-Rong Tseng
Jonsson Comprehensive Cancer Center, University of California los angeles
Co-authored papers 11
Edwin M Posadas
Cedars-Sinai Medical Center
Co-authored papers 5
Vatche G Agopian
David Geffen School of Medicine , University of California los angeles
Co-authored papers 5
Alan Mackay
Co-authored papers 5
Jorge S Reis-Filho
Memorial Sloan-Kettering Cancer Center
Co-authored papers 5
Clare M Isacke
Co-authored papers 4
Yu Jen Jan
Cedars-Sinai Medical Center
Co-authored papers 4
Kara L Britt
Co-authored papers 3
Jos Jonkers
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 2
Li-Ching Chen
College of Life Science, China Medical University Taichung 406040
Co-authored papers 2
Jie-Fu Chen
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 1
Huiying Li
University of California irvine
Co-authored papers 1
Andrea Bertotti
Candiolo Cancer Institute - FPO IRCCS
Co-authored papers 1
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Michelson Center for Convergent Bioscience, University of Southern California
Co-authored papers 1
Peter Kuhn
University of Tubingen
Co-authored papers 1
Bryan Moy
Co-authored papers 1
Phillip G Febbo
Illumina Inc.
Co-authored papers 1
Sean E Hanlon
Drew University, National Institutes of Health, Rutgers University New Brunswick, University of North Carolina at Chapel Hill
Co-authored papers 1
Jake Vinson
Prostate Cancer Clinical Trials Consortium (PCCTC)
Co-authored papers 1
Jonathan Franca-Koh
J Craig Venter Institute
Co-authored papers 1
Andrew Schade
Co-authored papers 1
Robert L Grossman
University of Chicago
Co-authored papers 1
Matthew Ryder
Co-authored papers 1
Robert C Stein
12 University College London Hospitals National Health Service Foundation Trust
Co-authored papers 1
Carolyn Compton
College of American Pathologists
Co-authored papers 1
Daniel L Edelstein
Sysmex Inostics Inc.
Co-authored papers 1
AmirAli Talasaz
University of California San Diego Moores Cancer Center
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Release 1.2