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Author Details

Yu Huang
Gladstone Institutes San Francisco
2004
38
25
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36711864Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.bioRxiv2023
35061545Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.Circulation2022
35673562Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction.Theranostics2022
35938400Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.Circulation2022
35896549Targeting transcription in heart failure via CDK7/12/13 inhibition.Nat Commun2022
35182466Transcription factor protein interactomes reveal genetic determinants in heart disease.Cell2022
33303684Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.Science2021
34713723The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction.J Am Heart Assoc2021
34006853Adropin-based dual treatment enhances the therapeutic potential of mesenchymal stem cells in rat myocardial infarction.Cell Death Dis2021
34163071A transcriptional switch governs fibroblast activation in heart disease.Nature2021
33094644BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.Circulation2020
32106109Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.J Clin Invest2020
31147515Oligogenic inheritance of a human heart disease involving a genetic modifier.Science2019
31784461Minimal <i>in vivo</i> requirements for developmentally regulated cardiac long intergenic non-coding RNAs.Development2019
29502971Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.Cell2018
27834668Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.Circulation2017
28346225Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.J Clin Invest2017
28515341BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.Sci Transl Med2017
28877458Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.Cell Metab2017
26932671KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.Development2016
27127239Conversion of human fibroblasts into functional cardiomyocytes by small molecules.Science2016
26942852Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.Cell Stem Cell2016
23085412Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning.Dev Biol2013
24252873microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.Elife2013
23658642AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.PLoS One2013
22267199Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.Nat Genet2012
22522929In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.Nature2012
21497762A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity.Dev Cell2011
21573063Elevated miR-499 levels blunt the cardiac stress response.PLoS One2011
21690310Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.J Cell Biol2011
21383058miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes.J Exp Med2011
20558827Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance.Circ Res2010
18295361Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart.Int J Cardiol2009
19554624Combining angiogenic gene and stem cell therapies for myocardial infarction.J Gene Med2009
18044793AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid.J Gene Med2008
18789891VEGF improves survival of mesenchymal stem cells in infarcted hearts.Biochem Biophys Res Commun2008
16775632AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect.Gene Ther2006
15534198Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts.Proc Natl Acad Sci U S A2004
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Collaborators

Deepak Srivastava
Gladstone Institutes San Francisco
Co-authored papers 23
Benoit G Bruneau
Gladstone Institutes of Cardiovascular Disease, Gladstone Institutes
Co-authored papers 9
Arun Padmanabhan
Gladstone Institutes San Francisco
Co-authored papers 6
Michael Alexanian
Gladstone Institutes San Francisco
Co-authored papers 5
Casey A Gifford
Gladstone Institutes, USA Roddenberry Center for Stem Cell Biology at Gladstone
Co-authored papers 5
Christopher Ian Spencer
Gladstone Institute of Cardiovascular Disease
Co-authored papers 4
Lei Liu
Center for Developmental Biology, Anhui Agricultural University
Co-authored papers 4
Katherine S Pollard
Gladstone Institutes
Co-authored papers 4
Yen-Sin Ang
Gladstone Institutes
Co-authored papers 4
Kathryn N Ivey
Gladstone Institutes, USA Roddenberry Center for Stem Cell Biology at Gladstone
Co-authored papers 4
B??rbara Gonz??lez-Ter??n
Gladstone Institutes, USA Roddenberry Center for Stem Cell Biology at Gladstone
Co-authored papers 4
Bruce R Conklin
Gladstone Institutes
Co-authored papers 4
Vasanth Vedantham
University of California san francisco
Co-authored papers 3
Reuben Thomas
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes
Co-authored papers 3
Krishna Choudhary
Gladstone Institutes of Cardiovascular Disease, Gladstone Institutes
Co-authored papers 3
Angelo Pelonero
Gladstone Institutes, USA Roddenberry Center for Stem Cell Biology at Gladstone
Co-authored papers 3
Sarah McMahon
Gladstone Institutes
Co-authored papers 3
Amy Foley
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 2
Nathanael S Gray
Harvard Medical School
Co-authored papers 2
Tao Xu
Co-authored papers 2
Nicole R Stone
Gladstone Institutes
Co-authored papers 2
Jonathan G Seidman
Harvard Medical School
Co-authored papers 2
Pawel F Przytycki
Co-authored papers 2
Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 2
Brian L Black
Cardiovascular Research Institute, University of California san francisco
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Christine E Seidman
Brigham and Women's Hospital (Y.K.
Co-authored papers 2
Diane Fatkin
Co-authored papers 1
Sarah U Morton
Boston Children's Hospital
Co-authored papers 1
Austin Hsu
Gladstone Institutes
Co-authored papers 1
Release 1.2