Author details

Full Name

Frank Westermann

Affiliation

ORCID

Career Start Year

1996

Papers

133

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37647861	Asymmetric Adrenals: Sexual Dimorphism of Adrenal Tumors.	J Clin Endocrinol Metab	2024
37524526	Exploring the impact of dexamethasone on gene regulation in myeloma cells.		2023
36973454	Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome.	Nat Genet	2023
36949154	Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking.	Leukemia	2023
36493725	Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of neuroblastoma.	EBioMedicine	2023
36807339	Genomic ALK alterations in primary and relapsed neuroblastoma.	Br J Cancer	2023
36476835	Correction: Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma.	Oncogene	2023
37361539	HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics.		2023
37528411	Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes.	Genome Biol	2023
34636058	Neuroblastoma-Telomere maintenance, deregulated signaling transduction and beyond.	International Journal of Cancer	2022
36175618	Genome wide DNA methylation analysis identifies novel molecular subgroups and predicts survival in neuroblastoma.	Br J Cancer	2022
36333584	In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.	Leukemia	2022
35484422	MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.	Nat Cancer	2022
36575299	Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM.	NPJ Precis Oncol	2022
35188570	ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats.	Nucleic Acids Res	2022
35159116	Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models.	Cancers (Basel)	2022
35121888	Super enhancers define regulatory subtypes and cell identity in neuroblastoma.	Nat Cancer	2021
34289372	Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer.	Cell Reports	2021
33627664	Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome.	Nat Commun	2021
34110923	FOXR2 Stabilizes MYCN Protein and Identifies Non-<i>MYCN</i>-Amplified Neuroblastoma Patients With Unfavorable Outcome.	J Clin Oncol	2021
33767450	Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.	Nat Genet	2021
33658318	Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.	Life Sci Alliance	2021
32822486	Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.	Neuro Oncol	2021
34503286	Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma.	Cancers (Basel)	2021
34373263	The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets.	Cancer Discov	2021
32846370	Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.	eBioMedicine	2020
32131402	Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines.	Cancers (Basel)	2020
33233777	Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation.	Cancers (Basel)	2020
33121173	Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts.	Pharmaceuticals (Basel)	2020
30770954	Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.	Cell Mol Life Sci	2019
30538293	ALK positively regulates MYCN activity through repression of HBP1 expression.	Oncogene	2019
31300807	Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.	Nat Rev Cancer	2019
31511524	Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.	Nat Commun	2019
30836646	Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes.	International Journal of Molecular Sciences	2019
29515255	A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment.	Cell Death Differ	2018
30552333	Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.	Nature Communications	2018
30451831	TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.	Nat Commun	2018
29947893	The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.	Arch Toxicol	2018
30523111	A mechanistic classification of clinical phenotypes in neuroblastoma.	Science	2018
29489754	The landscape of genomic alterations across childhood cancers.	Nature	2018
28843484	Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.	Cell Systems	2017
28680756	Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.	Oncoimmunology	2017
27622013	The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells.	OncoImmunology	2016
27479119	Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.	Eur J Cancer	2016
26598443	Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma.	Mol Oncol	2016
26631615	Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.	Clin Cancer Res	2016
26683771	MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.	Cancer Lett	2016
27533138	Establishment of an Immortalized Skin Keratinocyte Cell Line Derived from the Animal Model Mastomys coucha.	PLoS ONE	2016
27531891	Wnt signalling is a bi-directional vulnerability of cancer cells.	Oncotarget	2016
27635046	Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas.	Cancer Res	2016