Author details

Full Name

Joost H A Martens

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36546837	Transcription factor HNF1Î² controls a transcriptional network regulating kidney cell structure and tight junction integrity.		2023
37995184	Acid ceramidase regulates innate immune memory.		2023
37886034	Understanding blood development and leukemia using sequencing-based technologies and human cell systems.		2023
37612044	Saponin-based adjuvants enhance antigen cross-presentation in human CD11c CD1c CD5 CD163 conventional type 2 dendritic cells.		2023
36779734	Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic.		2023
36807648	High expression of an intragenic long noncoding RNA misinterpreted as high FTO oncogene expression in NPM1 mutant acute myeloid leukemia.		2023
37190104	Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation.		2023
35315319	Presence of mutant p53 increases stem cell frequency and is associated with reduced binding to classic TP53 binding sites in cell lines and primary AMLs.	Experimental Hematology	2022
35681235	CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway.	Molecular Cancer	2022
35986270	Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.	Molecular Cancer	2022
35730653	Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias.	Clinical and Translational Medicine	2022
35984907	Dietary methionine starvation impairs acute myeloid leukemia progression.	Blood	2022
36411286	Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability.	Nature Communications	2022
34162697	Dynamics of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes.	Genome Research	2022
34450246	Characterization of a genomic region 8Â kb downstream of GFI1B associated with myeloproliferative neoplasms.		2021
33690840	Specific proteome changes in platelets from individuals with GATA1-, GFI1B-, and RUNX1-linked bleeding disorders.	Blood	2021
34113809	The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia.	iScience	2021
33953289	Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.	Leukemia	2021
33521699	Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination.	Cell Reports Medicine	2021
33567618	The Role of Necroptosis: Biological Relevance and Its Involvement in Cancer.	Cancers	2021
33927210	Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells.	Sci Rep	2021
32703790	Cell type-specific novel long non-coding RNA and circular RNA in the BLUEPRINT hematopoietic transcriptomes atlas.	Haematologica	2021
33016232	Recent insights into : biological function and involvement in pathogenesis.	Epigenetics	2021
34853826	The EHA Research Roadmap: Normal Hematopoiesis.	HemaSphere	2021
32667968	Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.	J Exp Med	2020
31727766	CD34 acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax.	Haematologica	2020
31940477	CBFÎ²-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acute Myeloid Leukemia.	Cell Reports	2020
30709863	RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs.	Blood advances	2019
31698463	Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells.	Blood advances	2019
31648334	Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern.	Blood Adv	2019
31890203	HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells.	Cancer Metab	2019
31869378	The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model.	PLoS ONE	2019
30655368	Molecular mechanisms of bleeding disorderassociated GFI1B mutation and its affected pathways in megakaryocytes and platelets.	Haematologica	2019
31138842	The AAA+ATPase RUVBL2 is essential for the oncogenic function of c-MYB in acute myeloid leukemia.	Leukemia	2019
30850577	CBFÎ²-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1.	Blood Cancer Journal	2019
30673601	Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes.	Cell Rep	2019
31000698	BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition.	Cell Death and Disease	2019
31199668	The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK.	FASEB J	2019
31199242	Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock.	eLife	2019
29785028	The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia.	Nat Med	2018
28871137	C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.	Leukemia	2018
29876014	Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia.	Oncotarget	2018
29876013	Combined HAT/EZH2 modulation leads to cancer-selective cell death.	Oncotarget	2018
30337563	E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer.	Sci Rep	2018
30184510	Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.	Cell Rep	2018
29674496	GFI1 is required for <i>RUNX1/ETO</i> positive acute myeloid leukemia.	Haematologica	2018
29271969	miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.	Leukemia	2018
28114278	MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.	Oncogene	2017
28916762	Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.	Scientific Reports	2017
28703137	Platelet function is modified by common sequence variation in megakaryocyte super enhancers.	Nat Commun	2017