Author details

Full Name

Roberto Spreafico

Affiliation

ORCID

Career Start Year

2010

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37258672	A pan-influenza antibody inhibiting neuraminidase via receptor mimicry.	Nature	2023
37613467	How a Potent Anti-neuraminidase Monoclonal Antibody Navigates Recent Immune-evasive Influenza Strains: A Structural Study by Single-particle CryoEM.	Microsc Microanal	2023
37212045	Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses.		2023
35148840	An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.	Cell	2022
34333764	Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing.	European Journal of Immunology	2022
34492226	The interferon landscape along the respiratory tract impacts the severity of COVID-19.	Cell	2021
33621484	Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.	Cell	2021
34036652	Detection of viral gene expression in risk-stratified biopsies reveals no active HPV in cutaneous squamous cell carcinoma.	Exp Dermatol	2021
34140389	NF-ÎºB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages.	Science	2021
34031243	Transfer transcriptomic signatures for infectious diseases.	Proc Natl Acad Sci U S A	2021
32561710	Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing.	Nat Commun	2020
32422645	Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.	Nature	2020
32409528	Phased Diploid Genome Sequence for the Fast-Growing Microalga .	Microbiology Resource Announcements	2020
32101750	Dissecting the Regulatory Strategies of NF-ÎºB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics.	Cell Reports	2020
31768073	Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation.	Nat Immunol	2020
32887888	Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing.	Nat Commun	2020
32824125	Advances in Genomics for Drug Development.	Genes (Basel)	2020
32527925	Type III interferons disrupt the lung epithelial barrier upon viral recognition.	Science	2020
32972994	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.	Science	2020
32511354	Structural and functional analysis of a potent sarbecovirus neutralizing antibody.	bioRxiv	2020
30881956	From Big Data to Precision Medicine.	Front Med (Lausanne)	2019
31748741	PGRMC2 is an intracellular haem chaperone critical for adipocyte function.	Nature	2019
30918279	Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions.	Scientific Reports	2019
31019078	Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor.	Proc Natl Acad Sci U S A	2019
29548336	ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.	Genome Biol	2018
28237795	Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms.	Cell Systems	2017
28446598	The histone variant H2A.Z promotes efficient cotranscriptional splicing in <i>S. cerevisiae</i>.	Genes Dev	2017
28704551	Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.	PLoS Pathog	2017
27311837	TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis.	Ann Rheum Dis	2017
28283662	Exhaustion-associated regulatory regions in CD8<sup>+</sup> tumor-infiltrating T cells.	Proc Natl Acad Sci U S A	2017
27895176	The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum Adjuvants.	Journal of Immunology	2017
27624289	Increased autophagy in CD4<sup>+</sup> T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance.	Eur J Immunol	2016
25498120	A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment.	Ann Rheum Dis	2016
26845386	Antibody-Mediated Rejection in Lung Transplantation: Clinical Outcomes and Donor-Specific Antibody Characteristics.	Am J Transplant	2016
27406819	Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors.	EMBO Molecular Medicine	2016
26721397	Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei.	Proc Natl Acad Sci U S A	2016
27942590	Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation.	JCI Insight	2016
27849614	Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4+ T cell activation pathways.	Proc Natl Acad Sci U S A	2016
26508369	Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.	Nature Communications	2015
25452562	Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.	J Immunol	2015
25911462	Training the 21st Century Immunologist.	Trends in Immunology	2015
27279045	Regulatory T-Cell Therapy in Transplantation and Severe Autoimmunity.	Crit Rev Immunol	2015
25042685	A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples.	Eur J Immunol	2014
24496456	Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy.	British Journal of Cancer	2014
23541328	Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells.	J Allergy Clin Immunol	2013
24078690	Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-Î±Î² and are elevated in rheumatoid arthritis.	J Immunol	2013
23817414	Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1Î² release.	J Immunol	2013
24055061	IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions.	Cell Reports	2013
22207037	Similarities and differences of innate immune responses elicited by smooth and rough LPS.	Immunology Letters	2012
22058415	Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.	J Immunol	2011