Skip to Main Content

Author Details

Hans Gmuender
F. Hoffmann-La Roche Ltd
1993
40
23
PMIDPaper TitleJournal TitlePublished Year
34211507Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies.Front Genet2021
34462909A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.Clin Pharmacol Ther2021
33060801Network integration and modelling of dynamic drug responses at multi-omics levels.Commun Biol2020
30874586DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro.Sci Rep2019
28852801A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.Arch Toxicol2018
29803840Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.Toxicol Lett2018
29990954Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases.Environ Int2018
29320438Modeling Unobserved Heterogeneity in Susceptibility to Ambient Benzo[a]pyrene Concentration among Children with Allergic Asthma Using an Unsupervised Learning Algorithm.Int J Environ Res Public Health2018
27576363The exposome in practice: Design of the EXPOsOMICS project.Int J Hyg Environ Health2017
28807506Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms.Environ Pollut2017
27738743Xenobiotic metabolism in differentiated human bronchial epithelial cells.Arch Toxicol2017
27508094TMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions.Am J Cancer Res2016
26525393Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.Arch Toxicol2016
25505093diXa: a data infrastructure for chemical safety assessment.Bioinformatics2015
26298100Reduced gene expression levels after chronic exposure to high concentrations of air pollutants.Mutat Res2015
24252472Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.Environ Health Perspect2014
26417288Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?EXCLI J2014
23458556Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments.Mutat Res2013
23393228Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.Carcinogenesis2013
22269147Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure.Mutat Res2012
22738990Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns.Toxicol Sci2012
22879202Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero.Cancer Epidemiol Biomarkers Prev2012
20955723EU framework 6 project: predictive toxicology (PredTox)--overview and outcome.Toxicol Appl Pharmacol2011
21873647Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.Toxicol Sci2011
21315101A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat.Toxicol Appl Pharmacol2011
21388139A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties.J Med Chem2011
21144890In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals.Toxicol In Vitro2011
21081137Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers.Toxicol Appl Pharmacol2011
20888850The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury.Toxicol Appl Pharmacol2011
20702593Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in peripheral blood mononuclear cells.Toxicol Sci2010
19167446Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens.Food Chem Toxicol2009
17689568Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies.Mutat Res2008
18764936Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution.BMC Bioinformatics2008
18514569The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.Mutat Res2008
18310284Global gene expression profiles induced by phytoestrogens in human breast cancer cells.Endocr Relat Cancer2008
14998336New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine.J Med Chem2004
11808689Perspectives and challenges for DNA microarrays in drug discovery and development.Biotechniques2002
11156613Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis.Genome Res2001
10893304Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening.J Med Chem2000
8022866Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors.Pharmacol Ther1993
  • 1 - 40 of 40

Recommended Authors

Shraddha Thakkar
Center for Drug Evaluations and Research (CDER)
Career Start Year 2013
Number of shared co-authors 1
Stephenie D Prokopec
University Health Network
Career Start Year 2011
Number of shared co-authors 0
Nehme El-Hachem
Centre Hospitalier Universitaire Sainte-Justine Research Centre
Career Start Year 2011
Number of shared co-authors 1
Ashley Sawle
Cancer Research UK Cambridge Institute, University of Cambridge
Career Start Year 2010
Number of shared co-authors 0
Nicholas J W Rattray
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
Career Start Year 2008
Number of shared co-authors 0
Saskia Trump
Berlin Institute of Health at Charite - Universitatsmedizin Berlin
Career Start Year 2006
Number of shared co-authors 1
Linh-Chi Bui
INSERM UMR-S1124, Universite Paris Cite
Career Start Year 2005
Number of shared co-authors 0
Reuben Thomas
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes
Career Start Year 2004
Number of shared co-authors 0
Lyle D Burgoon
National Center for Environmental Assessment
Career Start Year 2004
Number of shared co-authors 1
Min Shen
National Center for Advancing Translational Sciences, National Institutes of Health
Career Start Year 2003
Number of shared co-authors 0
Susan C Tilton
Oregon State University
Career Start Year 2003
Number of shared co-authors 0
J??rg Rahnenf??hrer
TU Dortmund University
Career Start Year 2002
Number of shared co-authors 2
Scott S Auerbach
National Institute of Environmental Health Sciences
Career Start Year 2000
Number of shared co-authors 1
Wenjun Bao
SAS Institute Inc Cary
Career Start Year 2000
Number of shared co-authors 2
Hong Fang
National Center for Toxicological Research (NCTR)
Career Start Year 2000
Number of shared co-authors 4
Kerby Shedden
University of Michigan ann arbor
Career Start Year 1999
Number of shared co-authors 0
Carole L Yauk
University of Ottawa
Career Start Year 1996
Number of shared co-authors 2
Donatella Carpi
Joint Research Centre (JRC)
Career Start Year 1996
Number of shared co-authors 0
Katrina M Waters
Pacific Northwest National Laboratory
Career Start Year 1994
Number of shared co-authors 0
Sudhir Varma
Center for Cancer Research, National Cancer Institute
Career Start Year 1994
Number of shared co-authors 0
Russell D Wolfinger
SAS Institute
Career Start Year 1994
Number of shared co-authors 1
Gary Hardiman
Institute for Global Food Security, Queen's University Belfast
Career Start Year 1994
Number of shared co-authors 0
Weida Tong
National Center for Toxicological Research
Career Start Year 1992
Number of shared co-authors 4
Johan Lindberg
Karolinska Institute
Career Start Year 1988
Number of shared co-authors 1
Francois Pognan
Novartis
Career Start Year 1988
Number of shared co-authors 0
Stefan W??lfl
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University
Career Start Year 1987
Number of shared co-authors 0
Manuel C Peitsch
Philip Morris International Research Laboratories Pte. Ltd
Career Start Year 1987
Number of shared co-authors 0
Roberta Pastorelli
Istituto di Ricerche Farmacologiche Mario Negri IRCCS
Career Start Year 1984
Number of shared co-authors 0
Jennifer Fostel
National Institute of Environmental Health Sciences
Career Start Year 1980
Number of shared co-authors 2
Rainer Spang
University of Regensburg
Career Start Year 1969
Number of shared co-authors 0

Collaborators

Jos C S Kleinjans
Maastricht University
Co-authored papers 17
Ralf Herwig
Max Planck Institute for Molecular Genetics
Co-authored papers 8
Radim J Sram
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
Co-authored papers 4
Anna Pastorkova
Institute of Experimental Medicine CAS
Co-authored papers 3
Miroslav Dost??l
Institute of Experimental Medicine, Czech Academy of Sciences
Co-authored papers 3
Pavel Rossner
Institute of Experimental Medicine of the Czech Academy of Sciences
Co-authored papers 3
Ugis Sarkans
Co-authored papers 3
Zdenko Herceg
Co-authored papers 2
Stephane Heymans
Maastricht University Medical Centre
Co-authored papers 2
Roel Vermeulen
Co-authored papers 2
Hyunok Choi
College of Health, Lehigh University
Co-authored papers 2
Rob H Stierum
Co-authored papers 2
Nana Tabashidze
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
Co-authored papers 2
Peter Martus
Eberhard Karls University of Tuebingen
Co-authored papers 1
Anne Hersey
Co-authored papers 1
Paul L Carmichael
Co-authored papers 1
Susanna-Assunta Sansone
Oxford e-Research Centre, University of Oxford
Co-authored papers 1
Philippe Rocca-Serra
University of Oxford
Co-authored papers 1
Clemens Wittwehr
Co-authored papers 1
Frank Staedtler
Co-authored papers 1
John Wright
Co-authored papers 1
Chris T Evelo
Maastricht University
Co-authored papers 1
J??rgen Hescheler
Institute of Neurophysiology, University of Cologne
Co-authored papers 1
John P Overington
Institute of Cardiovascular Science, University College London
Co-authored papers 1
Hugo J W L Aerts
Harvard Medical School
Co-authored papers 1
Dominic Clark
European Bioinformatics Institute
Co-authored papers 1
Sek Won Kong
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
Co-authored papers 1
Bernd Kuhn
Co-authored papers 1
Atanas Kamburov
Broad Institute of Harvard and MIT
Co-authored papers 1
Release 1.2