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Author Details

Alan Aderem
Seattle Children's Research Institute
1979
228
95
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
33693706Use of a Contained Mycobacterium tuberculosis Mouse Infection Model to Predict Active Disease and Containment in Humans.J Infect Dis2022
35738280A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.Cell Chem Biol2022
36018279Genetic Modification of Primary Human Myeloid Cells to Study Cell Migration, Activation, and Organelle Dynamics.Curr Protoc2022
34031149ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation.J Immunol2021
34077724Type I interferon decreases macrophage energy metabolism during mycobacterial infection.Cell Rep2021
31065106Liver stage malaria infection is controlled by host regulators of lipid peroxidation.Cell Death Differ2020
31968263A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.Cell Rep2020
33171100Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.Cell2020
32581129PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection.Proc Natl Acad Sci U S A2020
32766585Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories.bioRxiv2020
32995363Flow Cytometry Analysis and Fluorescence-activated Cell Sorting of Myeloid Cells from Lung and Bronchoalveolar Lavage Samples from <i>Mycobacterium tuberculosis</i>-infected Mice.Bio Protoc2020
32673357Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection.PLoS Pathog2020
32785687Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.J Cell Biol2020
32411130The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection.Front Immunol2020
31110314CD8<sup>+</sup> T cells induce cachexia during chronic viral infection.Nat Immunol2019
31350281Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response <i>to Mycobacterium tuberculosis</i> in vivo.Sci Immunol2019
31534238Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.Nat Immunol2019
30833303Path-seq identifies an essential mycolate remodeling program for mycobacterial host adaptation.Mol Syst Biol2019
29325117Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures.J Infect Dis2018
29544097Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.Cell Host Microbe2018
29624071Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis.Am J Respir Crit Care Med2018
29334373Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.Nat Med2018
28922390Identifying novel transcription factors involved in the inflammatory response by using binding site motif scanning in genomic regions defined by histone acetylation.PLoS One2017
28193898Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.Proc Natl Acad Sci U S A2017
28380049miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.PLoS Pathog2017
29050771Host blood RNA signatures predict the outcome of tuberculosis treatment.Tuberculosis (Edinb)2017
29296883Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs.Blood Adv2017
29145483Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.PLoS Pathog2017
28637884Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.J Exp Med2017
26755593Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.Proc Natl Acad Sci U S A2016
27681624MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis.Proc Natl Acad Sci U S A2016
27322481Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial.EBioMedicine2016
27017310A blood RNA signature for tuberculosis disease risk: a prospective cohort study.Lancet2016
25419628The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.Nat Immunol2015
26320999Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.Cell Host Microbe2015
26588782Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.Immunity2015
26282876Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.J Exp Med2015
26102534Systems integration of innate and adaptive immunity.Vaccine2015
26153856Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.Nature2015
25902482Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.Immunity2015
25642773Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling.J Clin Invest2015
25755249An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.EMBO J2015
24243730Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model.J Gen Virol2014
25977790A comprehensive collection of systems biology data characterizing the host response to viral infection.Sci Data2014
25474352Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.PLoS Genet2014
25240016Macrophage activation as an effector mechanism for cell-mediated immunity.J Immunol2014
2499490125-Hydroxycholesterol acts as an amplifier of inflammatory signaling.Proc Natl Acad Sci U S A2014
24528862A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis.Cell Host Microbe2014
24655298Systems-level analysis of innate immunity.Annu Rev Immunol2014
24727652Multiscale representation of genomic signals.Nat Methods2014
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Collaborators

Seattle Children's Research Institute
Co-authored papers 20
Seattle Children's Research Institute
Co-authored papers 16
Oregon State University
Co-authored papers 10
Genentech Inc.
Co-authored papers 9
Institute for Systems Biology
Co-authored papers 8
Co-authored papers 8
Co-authored papers 8
Universidad Antonio Narino
Co-authored papers 7
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 7
Co-authored papers 7
Johns Hopkins University
Co-authored papers 7
Temple University
Co-authored papers 6
Lausanne University Hospital
Co-authored papers 6
Center for Infectious Disease Research
Co-authored papers 6
Institute for Systems Biology
Co-authored papers 6
Center for Infectious Disease Research
Co-authored papers 6
University of Washington
Co-authored papers 6
Center for Phenomic Health, The Buck Institute for Research on Aging
Co-authored papers 5
Mater Research Institute-UQ, Translational Research Institute
Co-authored papers 4
Co-authored papers 4
Institute for Immunity, Stanford University School of Medicine, Stanford University
Co-authored papers 4
St. Jude Children's Research Hospital
Co-authored papers 4
Institute for Systems Biology
Co-authored papers 4
Seattle Children's Research Institute, University of Washington
Co-authored papers 3
Co-authored papers 3
Rockefeller University
Co-authored papers 3
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 3
Case Western Reserve University and University Hospitals Cleveland Medical Center
Co-authored papers 3
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 3
Drukier Institute for Children's Health
Co-authored papers 3