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Author Details

Zhuyin Li
National Center for Advancing Translational Sciences, National Institutes of Health
1994
35
19
PMIDPaper TitleJournal TitlePublished Year
33422603Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists.Bioorg Med Chem Lett2021
33822623Discovery and Optimization of 2<i>H</i>-1λ<sup>2</sup>-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.J Med Chem2021
33422603Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists.Bioorg Med Chem Lett2021
34408078The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.Sci Transl Med2021
33822623Discovery and Optimization of 2<i>H</i>-1λ<sup>2</sup>-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.J Med Chem2021
34408078The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.Sci Transl Med2021
32192654Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction.J Am Coll Cardiol2020
32203152Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types.Lab Invest2020
32192654Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction.J Am Coll Cardiol2020
31843232Effect of Serum Albumin Levels in Patients With Heart Failure With Preserved Ejection Fraction (from the TOPCAT Trial).Am J Cardiol2020
31926856Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone.JACC Heart Fail2020
32089075Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease.Physiol Genomics2020
32873881Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis.Sci Rep2020
32803990Plasma Tenascin-C: a prognostic biomarker in heart failure with preserved ejection fraction.Biomarkers2020
32089075Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease.Physiol Genomics2020
31843232Effect of Serum Albumin Levels in Patients With Heart Failure With Preserved Ejection Fraction (from the TOPCAT Trial).Am J Cardiol2020
31926856Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone.JACC Heart Fail2020
32803990Plasma Tenascin-C: a prognostic biomarker in heart failure with preserved ejection fraction.Biomarkers2020
32873881Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis.Sci Rep2020
32203152Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types.Lab Invest2020
29248646Symptom Onset in Aortic Stenosis: Relation to Sex Differences in Left Ventricular Remodeling.JACC Cardiovasc Imaging2019
29248646Symptom Onset in Aortic Stenosis: Relation to Sex Differences in Left Ventricular Remodeling.JACC Cardiovasc Imaging2019
30972180Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.Am J Transl Res2019
30898214Soluble FMS-Like Tyrosine Kinase-1 Is a Circulating Biomarker Associated With Calcific Aortic Stenosis.J Am Coll Cardiol2019
31308926Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes.Ther Adv Endocrinol Metab2019
31308926Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes.Ther Adv Endocrinol Metab2019
30898214Soluble FMS-Like Tyrosine Kinase-1 Is a Circulating Biomarker Associated With Calcific Aortic Stenosis.J Am Coll Cardiol2019
30972180Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.Am J Transl Res2019
29555419Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.Bioorg Med Chem2018
29877628Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.Clin Transl Sci2018
29555419Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.Bioorg Med Chem2018
29877628Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.Clin Transl Sci2018
26838815Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.Nat Commun2016
26838815Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.Nat Commun2016
27428418A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.EBioMedicine2016
26341717A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.Methods2016
27681596Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.J Biol Chem2016
27552339Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.ACS Chem Biol2016
26341717A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.Methods2016
27681596Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.J Biol Chem2016
27428418A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.EBioMedicine2016
27552339Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.ACS Chem Biol2016
25653139Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.Nat Commun2015
25653139Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.Nat Commun2015
25945839Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis.Oncotarget2015
25944801Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer.Clin Cancer Res2015
25940539Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer.Oncotarget2015
26260604High-Throughput Screening for Allosteric Modulators of GPCRs.Methods Mol Biol2015
26260604High-Throughput Screening for Allosteric Modulators of GPCRs.Methods Mol Biol2015
25945839Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis.Oncotarget2015
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Collaborators

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Co-authored papers 14
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Co-authored papers 3
National Institute of Child Health and Development
Co-authored papers 3
Stanford University School of Medicine
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Co-authored papers 3
Center for Cancer Research, Maryland. Geisel School of Medicine at Dartmouth
Co-authored papers 3
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Co-authored papers 3
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University of Chicago
Co-authored papers 2
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 2
Johns Hopkins School of Medicine, National Cancer Institute, Princeton University, University of Colorado Anschutz Medical Campus, University of Pittsburgh, University of Washington
Co-authored papers 2
St. George's University Medical School
Co-authored papers 2
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Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
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Mayo Clinic School of Medicine, Mayo Clinic
Co-authored papers 1
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Mayo Clinic Jacksonville
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National Cancer Institute, National Institutes of Health
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The University of North Carolina
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Center for Cancer Research, National Cancer Institute, National Institutes of Health
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Vertex Pharmaceuticals
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Clinical Evidence Generation, Eisai Inc.
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