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Author Details

Anne T Nies
and University of Tuebingen, University of Tuebingen
1995
87
43
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37775020Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation.Pharmacol Res2023
34486071Two experts and a newbie: [<sup>18</sup>F]PARPi vs [<sup>18</sup>F]FTT vs [<sup>18</sup>F]FPyPARP-a comparison of PARP imaging agents.Eur J Nucl Med Mol Imaging2022
35806468Hepatic Expression of the Na<sup>+</sup>-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.Int J Mol Sci2022
35995278Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation.Pharmacol Ther2022
33455503Differential <i>in vitro</i> interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters.Xenobiotica2021
33495337Targeting OCT3 attenuates doxorubicin-induced cardiac injury.Proc Natl Acad Sci U S A2021
33674913Genetic and Epigenetic Regulation of Organic Cation Transporters.Handb Exp Pharmacol2021
33802215Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters.Pharmaceutics2021
33523504Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors.Fundam Clin Pharmacol2021
34025422Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1.Front Pharmacol2021
33434947Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.Br J Pharmacol2021
31350763Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1.Clin Pharmacol Ther2020
31834804Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space.Mol Pharm2020
33013684The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans.Front Endocrinol (Lausanne)2020
32867487Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs.Anal Chem2020
32308125Pharmacoresponse in genetic generalized epilepsy: a genome-wide association study.Pharmacogenomics2020
32141622Testing association of rare genetic variants with resistance to three common antiseizure medications.Epilepsia2020
30189235Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines.Toxicol In Vitro2019
29059457Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.Hepatology2018
29944835Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.Mol Pharm2018
29890226The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy.Drug Discov Today2018
30070687Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma.Int J Cancer2018
28539468Comment on "Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin".Sci Transl Med2017
28140687The importance of drug transporter characterization to precision medicine.Expert Opin Drug Metab Toxicol2017
28209616OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.Cancer Res2017
25896536Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant.Pharmacogenomics J2016
26410689Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics.Clin Pharmacokinet2016
27659854Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors.Trends Pharmacol Sci2016
27165417Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.Arch Toxicol2016
27435027Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes.Sci Rep2016
26979622A phosphotyrosine switch regulates organic cation transporters.Nat Commun2016
26239079Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.Pharmacogenomics J2016
25418285Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here?J Intern Med2015
26384346MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma.Oncotarget2015
25860377Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Clin Pharmacokinet2015
25640272Role of ABC transporters in fluoropyrimidine-based chemotherapy response.Adv Cancer Res2015
24397389Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research.Expert Opin Drug Metab Toxicol2014
25231932Differential expression of drug uptake and efflux transporters in Japanese patients with hepatocellular carcinoma.Drug Metab Dispos2014
24566939Genetic biomarkers in epilepsy.Neurotherapeutics2014
24352644Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).Clin Cancer Res2014
23277337Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects.Trends Pharmacol Sci2013
23881922DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome.Clin Cancer Res2013
23709238Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome.Rheumatology (Oxford)2013
23311897Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.Genome Med2013
22457399Organic anion transporters and their implications in pharmacotherapy.Pharmacol Rev2012
22970772Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs.Expert Opin Drug Metab Toxicol2012
22783830Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data.Expert Opin Pharmacother2012
22453193Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation.Clin Pharmacol Ther2012
21103969Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.Handb Exp Pharmacol2011
22196450DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma.Genome Med2011
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Collaborators

and of Biochemistry and Pharmacy, University of Tuebingen
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University of Luxembourg
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Sino-French Hoffmann Institute, Guangzhou Medical University
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The Ohio State University
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University of California San Francisco
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Institute of Pathology, Friedrich-Alexander University Erlangen-Nurnberg (FAU)
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Clinic for Plastic, Otto von Guericke University
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