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Author Details

Gwenn A Garden
University of Washington School of Medicine
1988
70
36
PMIDPaper TitleJournal TitlePublished Year
36879321Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures.J Neuroinflammation2023
37248328Human microglia show unique transcriptional changes in Alzheimer's disease.Nat Aging2023
35321655Validation of a computational phenotype for finding patients eligible for genetic testing for pathogenic PTEN variants across three centers.J Neurodev Disord2022
35441155A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal.Biol Psychiatry Glob Open Sci2022
34380760A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors.J Neurosci2021
33694209The pro-inflammatory microRNA miR-155 influences fibrillar β-Amyloid<sub>1</sub><sub>-42</sub> catabolism by microglia.Glia2021
35169706Brain capillary obstruction during neurotoxicity in a mouse model of anti-CD19 chimeric antigen receptor T-cell therapy.Brain Commun2021
31420975Ischemic preconditioning induces cortical microglial proliferation and a transcriptomic program of robust cell cycle activation.Glia2020
33188183Molecular estimation of neurodegeneration pseudotime in older brains.Nat Commun2020
33273466Author Correction: Molecular estimation of neurodegeneration pseudotime in older brains.Nat Commun2020
33391257Cytokines in CAR T Cell-Associated Neurotoxicity.Front Immunol2020
32741831Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype.J Alzheimers Dis2020
31020001Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.Ann Clin Transl Neurol2019
30028551Neuronal susceptibility to beta-amyloid toxicity and ischemic injury involves histone deacetylase-2 regulation of endophilin-B1.Brain Pathol2019
28683563Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells.ASN Neuro2017
25708596Recombinant adeno-associated viral (rAAV) vectors mediate efficient gene transduction in cultured neonatal and adult microglia.J Neurochem2016
27618651Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.Nat Med2016
27228454Glial biomarkers in human central nervous system disease.Glia2016
27246804Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.Glia2016
26148445MicroRNAs mediating CNS inflammation: Small regulators with powerful potential.Brain Behav Immun2016
25752338Glia: guardians, gluttons, or guides for the maintenance of neuronal connectivity?Ann N Y Acad Sci2015
26853851The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation.Crit Rev Immunol2015
26076170R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.JAMA Neurol2015
25981964Loss of endophilin-B1 exacerbates Alzheimer's disease pathology.Brain2015
24319262The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf.J Immunol2014
25367574miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.Immunity2014
25031461CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120.J Immunol2014
25108912Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.Nat Neurosci2014
24523556Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons.J Neurosci2014
23345212Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death.J Neurosci2013
23963788Epigenetics and the modulation of neuroinflammation.Neurotherapeutics2013
23952003Presenilin 2 influences miR146 level and activity in microglia.J Neurochem2013
23197655Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.Hum Mol Genet2013
22105777Emerging roles of p53 in glial cell function in health and disease.Glia2012
22405200Intercellular (mis)communication in neurodegenerative disease.Neuron2012
21598312Transcription factor p53 influences microglial activation phenotype.Glia2011
22072678Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.J Neurosci2011
19833801Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis.AJNR Am J Neuroradiol2010
21206757Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.PLoS One2010
20495529A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia.J Vis Exp2010
19228953Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.J Neurosci2009
19640278Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death.Mol Brain2009
19373562Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders.J Neuroimmune Pharmacol2009
19559752Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release.Neurosci Lett2009
18418675Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.Cerebellum2008
16978632Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging.Atherosclerosis2007
18040854The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes.J Neuroimmune Pharmacol2007
17488272Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis.J Neurochem2007
16469957Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results.Stroke2006
18040779Microglia biology in health and disease.J Neuroimmune Pharmacol2006
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Collaborators

Suman Jayadev
University of Washington
Co-authored papers 18
Christopher Dirk Keene
University of Washington
Co-authored papers 4
Stuart A Lipton
The Scripps Research Institute, University of California
Co-authored papers 3
Huy Nguyen
The University of Danang-University of Science and Technology
Co-authored papers 3
Benjamin A Logsdon
Fred Hutchinson Cancer Research Center
Co-authored papers 3
Sumit Mukherjee
Microsoft Corporation
Co-authored papers 2
Solveig K Sieberts
University of Washington
Co-authored papers 2
Christoph Preuss
Universite de Montreal
Co-authored papers 2
Philip L De Jager
Columbia University Medical Center
Co-authored papers 2
Thomas D Bird
University of Washington School of Medicine
Co-authored papers 2
Michael O Dorschner
University of Washington
Co-authored papers 2
Lara M Mangravite
Children's Hospital Oakland Research Institute
Co-authored papers 2
James B Leverenz
Lou Ruvo Center for Brain Health, Cleveland Clinic
Co-authored papers 2
Nil??fer Ertekin-Taner
Mayo Clinic
Co-authored papers 2
Anna K Greenwood
Fred Hutchinson Cancer Research Center
Co-authored papers 2
Gregory W Carter
Tufts University School of Medicine
Co-authored papers 2
Jennifer Tisoncik-Go
Center for Innate Immunity and Immune Disease, University of Washington
Co-authored papers 1
Shannon E Rose
University of Washington, USA Institute for Stem Cell and Regenerative Medicine
Co-authored papers 1
Kostantin Kiianitsa
University of Washington
Co-authored papers 1
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 1
Santhosh Girirajan
The Huck Institutes of Life Sciences, University Park, Pennsylvania State University
Co-authored papers 1
Michael Gale
Center for Innate Immunity and Immune Disease, University of Washington
Co-authored papers 1
Lisa M Ellerby
Buck Institute for Research on Aging
Co-authored papers 1
Gail P Jarvik
University of Washington Medical Center
Co-authored papers 1
Mustafa Sahin
Harvard Medical School
Co-authored papers 1
Noah Snyder-Mackler
Co-authored papers 1
Stephen R Plymate
University of Washington
Co-authored papers 1
Thomas J Montine
Stanford University
Co-authored papers 1
Malia Rumbaugh
Indiana University School of Medicine
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Lisa Hanson
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Release 1.2